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1.
Nano Lett ; 24(2): 764-769, 2024 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-38166141

RESUMO

Thermal emissions with high coherence, although not as high as those of lasers, still play a crucial role in many practical applications. In this work, by exploiting the geometric perturbation-induced optical lattice tripling and the associated Brillion zone folding effect, we propose and investigate thermal emissions in the mid-infrared with simultaneous high temporal and spatial coherence. In contrast with the case of period-doubling perturbation in our previous work, the steeper part of the guided mode dispersion band will be folded to the high-symmetry Γ point in the ternary grating. In this case, a specific emission wavelength corresponds to only a very small range of wavevectors. Consequently, apart from the high temporal coherence characterized by an experimental bandwidth around 30 nm, the achieved thermal emissions also feature ultrahigh spatial coherence. Calculations show that at the thermal emission wavelengths in the mid-infrared, the spatial coherence length can easily reach up to mm scale.

2.
Opt Express ; 32(5): 7896-7906, 2024 Feb 26.
Artigo em Inglês | MEDLINE | ID: mdl-38439459

RESUMO

We demonstrate the design, fabrication, and experimental characterization of a single transverse mode adiabatic microring resonator (MRR) implemented using the silicon-on- insulator (SOI) platform using local oxidation of silicon (LOCOS) approach. Following its fabrication, the device was characterized experimentally and an ultrahigh intrinsic Q-factor of ∼2 million with a free spectral range (FSR) of 2 nm was achieved, giving rise to a finesse of ∼1100, the highest demonstrated so far in SOI platform at the telecom band. We have further studied our device to analyze the source of losses that occur in the MRR and to understand the limits of the achievable Q-factor. The surface roughness was quantified using AFM scans and the root mean square roughness was found to be ∼ 0.32±0.03 nm. The nonlinear losses were further examined by coupling different optical power levels into the MRR. Indeed, we could observe that the nonlinear losses become more pronounced at power levels in the range of hundreds of microwatts. The demonstrated approach for constructing high-Q and high finesse MRRs can play a major role in the implementation of devices such as modulators, sensors, filters, frequency combs and devices that are used for quantum applications, e.g., photon pair generation.

3.
Mol Psychiatry ; 2023 Nov 09.
Artigo em Inglês | MEDLINE | ID: mdl-37945694

RESUMO

Modern research data suggest a therapeutic role for serotonergic psychedelics in depression and other neuropsychiatric disorders, although psychotomimetic effects may limit their widespread utilization. Serotonergic psychedelics enhance neuroplasticity via serotonin 2 A receptors (5HT2AR) activation and complex serotonergic-glutamatergic interactions involving the ionotropic glutamate receptors, tropomyosin receptor kinase B (TrkB) and the mammalian target of rapamycin (mTOR). N-methyl-d-aspartate receptors (NMDAR) channel antagonists, i.e. ketamine, and glycine modulatory site full and partial agonists, i.e., D-serine (DSR) and D-cycloserine (DCS), share some of these mechanisms of action and have neuroplastic and antidepressant effects. Moreover, procognitive effects have been reported for DSR and DCS and 5HT2AR-NMDAR interactions modulate neuronal excitability in prefrontal cortex and represent a target for new antipsychotics. We hypothesize that the synchronous administration of a psychedelic and a NMDAR modulator may increase the therapeutic impact of each of the treatment components and allow for dose adjustments and improved safety. We propose to initially focus research on the acute concurrent administration of psilocybin and DSR or DCS in depression.

4.
Mol Psychiatry ; 28(1): 44-58, 2023 01.
Artigo em Inglês | MEDLINE | ID: mdl-36280752

RESUMO

Schizophrenia is a widespread psychiatric disorder that affects 0.5-1.0% of the world's population and induces significant, long-term disability that exacts high personal and societal cost. Negative symptoms, which respond poorly to available antipsychotic drugs, are the primary cause of this disability. Association of negative symptoms with cortical atrophy and cell loss is widely reported. Psychedelic drugs are undergoing a significant renaissance in psychiatric disorders with efficacy reported in several conditions including depression, in individuals facing terminal cancer, posttraumatic stress disorder, and addiction. There is considerable evidence from preclinical studies and some support from human studies that psychedelics enhance neuroplasticity. In this Perspective, we consider the possibility that psychedelic drugs could have a role in treating cortical atrophy and cell loss in schizophrenia, and ameliorating the negative symptoms associated with these pathological manifestations. The foremost concern in treating schizophrenia patients with psychedelic drugs is induction or exacerbation of psychosis. We consider several strategies that could be implemented to mitigate the danger of psychotogenic effects and allow treatment of schizophrenia patients with psychedelics to be implemented. These include use of non-hallucinogenic derivatives, which are currently the focus of intense study, implementation of sub-psychedelic or microdosing, harnessing of entourage effects in extracts of psychedelic mushrooms, and blocking 5-HT2A receptor-mediated hallucinogenic effects. Preclinical studies that employ appropriate animal models are a prerequisite and clinical studies will need to be carefully designed on the basis of preclinical and translational data. Careful research in this area could significantly impact the treatment of one of the most severe and socially debilitating psychiatric disorders and open an exciting new frontier in psychopharmacology.


Assuntos
Antipsicóticos , Alucinógenos , Transtornos Psicóticos , Esquizofrenia , Animais , Humanos , Alucinógenos/uso terapêutico , Alucinógenos/farmacologia , Esquizofrenia/tratamento farmacológico , Transtornos Psicóticos/tratamento farmacológico , Antipsicóticos/uso terapêutico
5.
Opt Lett ; 48(3): 620-623, 2023 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-36723547

RESUMO

Achieving high-Q resonances in the THz frequency range is significant for applications such as sensors, filters, and emitters. A promising approach for obtaining such resonances is by using metamaterials. However, high-Q resonances in THz metamaterials are usually limited by metallic radiation losses in the meta-atoms. In this Letter, we investigate both experimentally and numerically a complementary metallic disk-hole array (CMA) that uses the coupling between lattice resonances and Fabry-Pérot cavity resonances, and features in-substrate modes with experimentally obtained record breaking Q-factors of up to 750. To the best of our knowledge, this is the highest quality factor measured for free-space-coupled metallic metamaterial structure at THz frequencies.

6.
Nano Lett ; 22(7): 2786-2792, 2022 Apr 13.
Artigo em Inglês | MEDLINE | ID: mdl-35311279

RESUMO

One of the challenges for metasurface research is upscaling. The conventional methods for fabrication of metasurfaces, such as electron-beam or focused ion beam lithography, are not scalable. The use of ultraviolet steppers or nanoimprinting still requires large-size masks or stamps, which are costly and challenging in further handling. This work demonstrates a cost-effective and lithography-free method for printing optical metasurfaces. It is based on resonant absorption of laser light in an optical cavity formed by a multilayer structure of ultrathin metal and dielectric coatings. A nearly perfect light absorption is obtained via interferometric control of absorption and operating around a critical coupling condition. Controlled by the laser power, the surface undergoes a structural transition from random, semiperiodic, and periodic to amorphous patterns with nanoscale precision. The reliability, upscaling, and subwavelength resolution of this approach are demonstrated by realizing metasurfaces for structural colors, optical holograms, and diffractive optical elements.

7.
Opt Lett ; 45(24): 6779-6782, 2020 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-33325895

RESUMO

Integrated cylindrical vector vortex (CVV) emitters have been introduced and studied for their potential applications in classical optics and quantum optics technologies. In this work, we demonstrate that the emission angle of integrated CVV emitters can be engineered by taking advantage of the geometrical phase of a microring resonator. Two methods to superimpose an arbitrary phase profile on top of the integrated emitters are presented and compared. Angled emission of integrated vector vortex beams enables the use of chip-scale emitters for integrated nonlinear optics and for beam steering applications with orbital angular momentum.

8.
Opt Lett ; 45(14): 3869-3872, 2020 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-32667306

RESUMO

A metric for evaluation of overall metalens performance is presented. It is applied to determination of optimal operating spectral range of a metalens, both theoretically and experimentally. This metric is quite general and can be applied to the design and evaluation of future metalenses, particularly achromatic metalenses.

9.
Opt Lett ; 45(7): 2128-2131, 2020 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-32236086

RESUMO

We study experimentally the effect of oxide removal on the sub-bandgap photodetection in silicon waveguides at the telecom wavelength regime. Depassivating the device allows for the enhancement of the quantum efficiency by about 2-3 times. Furthermore, the propagation loss within the device is significantly reduced by the oxide removal. Measuring the device 60 days after the depassivation shows slight differences. We provide a possible explanation for these observations. Clearly, passivation and depassivation play an essential role in the design and the implementation of such sub-bandgap photodetector devices for applications such as on-chip light monitoring.

10.
Nano Lett ; 19(2): 1044-1051, 2019 02 13.
Artigo em Inglês | MEDLINE | ID: mdl-30608703

RESUMO

Metasurfaces provide new and promising mechanisms with which to control and manipulate light at the nanoscale. While most metasurfaces are designed to operate in the linear regime, it was recently shown that such metasurfaces may also generate nonlinear signals by manipulation of the higher-order susceptibility terms. As such, metasurfaces can generate additional harmonics without the need for light propagation, as typically occurs in nonlinear crystals. While such demonstrations typically rely on the nonlinear properties of metals, we hereby report the design, fabrication, and experimental characterization of a resonant dielectric metasurface made of amorphous silicon to create and manipulate second harmonic light and control its diffraction patterns. As shown in the paper, the second harmonic generation of light follows selection rules that rely on the asymmetry of the meta-atom. Given the fact that silicon crystals are centrosymmetric, the generation of the second harmonic signal in amorphous silicon is intriguing. In fact, the second harmonic signal is generated mostly from the surface of the meta-atom. It is the use of nanostructures that increases the surface-to-volume ratio and enables second harmonic generation. Additionally, the meta-atom is designed to exploit its spectral resonances in the principal and the second harmonic frequencies for providing electromagnetic field enhancement, which assists in boosting the generation of second harmonic signals.

11.
Opt Express ; 27(23): 33445-33458, 2019 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-31878414

RESUMO

We experimentally demonstrate hyperfine optical pumping of rubidium atoms probed by an evanescent electromagnetic field at a dielectric-vapor interface. This light-atom interaction at the nanoscale is investigated using a right angle prism integrated with a vapor cell and excited by evanescent wave under total internal reflection. An efficient hyperfine optical pumping, leading to almost complete suppression of absorption on the probed evanescent signal, is observed when a pump laser beam is sent at normal incidence to the interface. In contrast, when the pump and probe beams are co-propagating in the integrated prism-vapor cell, no clear evidence of optical pumping is observed. The experimental results are supported by a detailed model based on the optical Bloch equation of a four atomic-level structure, which also includes a treatment of transit relaxation and wall collision with relaxation rates that were obtained directly from the thermal velocities of the atoms and the penetration depth of the evanescent wave. The obtained highly efficient optical pumping at the nanoscale is regarded as an important step in the quest for applications such as optical switching, magnetometry, and quantum memory.

12.
Opt Lett ; 44(4): 971-974, 2019 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-30768033

RESUMO

The parametric four-wave mixing (4WM) process responsible for the generation of coherent blue light in alkali vapors is a self-seeded process which starts by population inversion and amplified spontaneous emission (ASE). Lately, attention has been turned toward frequency up- and down-conversion in alkali vapors, using relatively low pump powers with CW diode lasers. In this Letter, we investigate the interplay between ASE and 4WM in rubidium (Rb) vapors by studying the mid-infrared (mid-IR) radiation emitted in the forward direction at 5.23 µm. We show that the ASE can be suppressed by 4WM in the CW regime. Thus, we demonstrate the generation of coherent mid-IR light at 5.23 µm in hot Rb vapors via parametric 4WM.

13.
Nano Lett ; 18(1): 202-207, 2018 01 10.
Artigo em Inglês | MEDLINE | ID: mdl-29240438

RESUMO

Following the efforts of size reduction and the integration of light and vapor systems, great promise is held in the integration of vapor and confined electromagnetic waves. By confining light to nanoscale dimensions, fundamental properties of light-vapor interactions may vary significantly. For example, the state of polarization may be modified as compared with weakly focused beams. Specifically, in transverse magnetic modes, the existence of a longitudinal field component, which is in quadrature to the transverse field, generates a "circular-like" polarized light. Here, by taking advantage of this very property, we study the interaction of confined light and vapor in a coupled system of plasmons and atomic vapors in the presence of magnetic fields. Our results show that the spectroscopic nature and Fano resonances of the hybrid plasmonic-atomic system are greatly altered. In parallel, we also exploit the existence of the atoms in proximity to the plasmonic mode to probe the polarization state of the electromagnetic field and reveal the longitudinal-to-transverse ratio between the plasmonic modes components in the near field. Interestingly, our system maps the amplitude and phase information of the electromagnetic modes to the spectral domain. As such, combining magnetic fields with the coupled plasmonic-atomic system has the potential for future applications in high spatial resolution magnetometry, near-field vectorial imaging, and magnetically induced switching and tuning.

14.
Nano Lett ; 17(2): 1127-1131, 2017 02 08.
Artigo em Inglês | MEDLINE | ID: mdl-28125232

RESUMO

In recent years, dielectric and metallic nanoscale metasurfaces are attracting growing attention and are being used for variety of applications. Resulting from the ability to introduce abrupt changes in optical properties at nanoscale dimensions, metasurfaces enable unprecedented control over light's different degrees of freedom, in an essentially two-dimensional configuration. Yet, the dynamic control over metasurface properties still remains one of the ultimate goals of this field. Here, we demonstrate the optical resonant interaction between a form birefringent dielectric metasurface made of silicon and alkali atomic vapor to control and effectively tune the optical transmission pattern initially generated by the nanoscale dielectric metasurface. By doing so, we present a controllable metasurface system, the output of which may be altered by applying magnetic fields, changing input polarization, or shifting the optical frequency. Furthermore, we also demonstrate the nonlinear behavior of our system taking advantage of the saturation effect of atomic transition. The demonstrated approach paves the way for using metasurfaces in applications where dynamic tunability of the metasurface is in need, for example, for scanning systems, tunable focusing, real time displays, and more.


Assuntos
Álcalis/química , Nanoestruturas/química , Dispositivos Ópticos , Desenho de Equipamento , Cinética , Luz , Campos Magnéticos , Silício/química , Propriedades de Superfície , Volatilização
15.
Nano Lett ; 17(9): 5481-5488, 2017 09 13.
Artigo em Inglês | MEDLINE | ID: mdl-28771367

RESUMO

We experimentally demonstrate the interrogation of an individual Escherichia coli cell using a nanoscale plasmonic V-groove waveguide. Several different configurations were studied. The first involved the excitation of the cell in a liquid environment because it flows on top of the waveguide nanocoupler, while the obtained fluorescence is coupled into the waveguide and collected at the other nanocoupler. The other two configurations involved the positioning of the bacterium within the nanoscale waveguide and its excitation in a dry environment either directly from the top or through waveguide modes. This is achieved by taking advantage of the waveguide properties not only for light guiding but also as a mechanical tool for trapping the bacteria within the V-grooves. The obtained results are supported by a set of numerical simulations, shedding more light on the mechanism of excitation. This demonstration paves the way for the construction of an efficient bioplasmonic chip for diverse cell-based sensing applications.


Assuntos
Técnicas Biossensoriais/instrumentação , Escherichia coli/citologia , Dispositivos Lab-On-A-Chip , Nanoestruturas/química , Células Imobilizadas/química , Células Imobilizadas/citologia , Simulação por Computador , Desenho de Equipamento , Escherichia coli/química , Fluorescência , Modelos Biológicos
16.
Opt Express ; 25(18): 21637-21651, 2017 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-29041460

RESUMO

Recent progress has made matalenses a reality, with many publications relating to methods of implementation and performance evaluation of these elements. Basic metalens function is similar to that of a continuous (kinoform) diffractive lens, but the advantage is that they can be manufactured as a binary component. A significant limitation of metalenses, is its strong chromatic aberration. Recently there has been some success in correcting metalens chromatic aberration, albeit at the expense of transmission efficiency towards the desired diffraction order. Clearly, there is a tradeoff between parameters such as spectral bandwidth and spatial resolution. Hence, a major goal of this paper is to set up a metric for evaluation of metalens performance, allowing fair comparison of novel metalens technologies, such as achromatic metalenses, in terms of optical performance. Furthermore, we explore possibilities for practical use of non-chromatically corrected metalenses in polychromatic applications, by optimizing the metalens parameters. It is our hope that the current manuscript will serve as a guide for the design and evaluation of metalenses for practical applications.

17.
Opt Express ; 25(13): 14494-14503, 2017 Jun 26.
Artigo em Inglês | MEDLINE | ID: mdl-28789035

RESUMO

Nowadays, wide-field of view plasmonic structured illumination method (WFPSIM) has been extensively studied and experimentally demonstrated in biological researches. Normally, noble metal structures are used in traditional WFPSIM to support ultra-high wave-vector of SPs and an imaging resolution enhancement of 3-4 folds can be achieved. To further improve the imaging resolution of WFPSIM, we hereby propose a wide-field optical nanoimaging method based on a hybrid graphene on meta-surface structure (GMS) model. It is found that an ultra-high wave-vector of graphene SPs can be excited by a metallic nanoslits array with localized surface plasmon enhancement. As a result, a standing wave surface plasmons (SW-SPs) interference pattern with a period of 11 nm for a 980 nm incident wavelength can be obtained. The potential application of the GMS for wide-field of view super-resolution imaging is discussed followed by simulation results which show that an imaging resolution of sub-10 nm can be achieved. The demonstrated method paves a new route for wide field optical nanoimaging, with applications e.g. in biological research to study biological processes occurring in cell membrane.

18.
Nano Lett ; 16(12): 7956-7961, 2016 12 14.
Artigo em Inglês | MEDLINE | ID: mdl-27960507

RESUMO

We experimentally demonstrate a nanoscale mode converter that performs coupling between the first two transverse electric-like modes of a silicon-on-insulator waveguide. The device operates by introducing a nanoscale periodic perturbation in its effective refractive index along the propagation direction and a graded effective index profile along its transverse direction. The periodic perturbation provides phase matching between the modes, while the graded index profile, which is realized by the implementation of nanoscale dielectric metasurface consisting of silicon features that are etched into the waveguide taking advantage of the effective medium concept, provides the overlap between the modes. Following the device design and numerical analysis using three-dimensional finite difference time domain simulations, we have fabricated the device and characterized it by directly measuring the modal content using optical imaging microscopy. From these measurements, the mode purity is estimated to be 95% and the transmission relative to an unperturbed strip waveguide is as high as 88%. Finally, we extend this approach to accommodate for the coupling between photonic and plasmonic modes. Specifically, we design and numerically demonstrate photonic to plasmonic mode conversion in a hybrid waveguide in which photonic and surface plasmon polariton modes can be guided in the silicon core and in the silicon/metal interface, respectively. The same method can also be used for coupling between symmetric and antisymmetric plasmonic modes in metal-insulator-metal or insulator-metal-insulator structures. On the basis of the current demonstration, we believe that such nanoscale dielectric metasurface-based mode converters can now be realized and become an important building block in future nanoscale photonic and plasmonic devices. Furthermore, the demonstrated platform can be used for the implementation of other chip scale components such as splitters, combiners couplers, and more.

19.
Nano Lett ; 16(5): 3005-13, 2016 05 11.
Artigo em Inglês | MEDLINE | ID: mdl-27053042

RESUMO

We report an on-chip integrated metal graphene-silicon plasmonic Schottky photodetector with 85 mA/W responsivity at 1.55 µm and 7% internal quantum efficiency. This is one order of magnitude higher than metal-silicon Schottky photodetectors operated in the same conditions. At a reverse bias of 3 V, we achieve avalanche multiplication, with 0.37A/W responsivity and avalanche photogain ∼2. This paves the way to graphene integrated silicon photonics.

20.
Opt Express ; 24(5): 4834-4841, 2016 Mar 07.
Artigo em Inglês | MEDLINE | ID: mdl-29092311

RESUMO

Space variant beams are of great importance for a variety of applications that have emerged in recent years. As such, manipulation of their degrees of freedom is highly desired. Here, we study the general interaction of space variant beams with a magnetically influenced Rb medium exploiting the atoms versatile properties in terms of frequency and intensity dependent circular dichroism and circular birefringence. We present the particular cases of radially polarized and hybrid polarized beams where the control of the polarization states is demonstrated experimentally. Moreover, we show that such an atomic system can be used as a tunable analyzer for space variant beams. Finally, exploiting the non-linear properties of Rb vapor, we show that we can control the circular birefringence all optically, and thus modulate the polarization of the radial polarized beam.

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