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1.
Childs Nerv Syst ; 39(4): 857-861, 2023 04.
Artigo em Inglês | MEDLINE | ID: mdl-36658366

RESUMO

Although the posterior fossa is a common location for paediatric brain tumours [1], diffuse glioma isolated to the cerebellum is an extremely rare imaging entity. Only two cases of isolated diffuse paediatric cerebellar glioma have been reported in the English language to the best of our knowledge [2, 3], and only one of these cases had a similar imaging phenotype to our cases [3]. Although somewhat similar to Lhermitte-Duclos (dysplastic gangliocytoma of the cerebellum), the appearances are distinct from other neoplastic entities of the paediatric posterior fossa. Clinical presentation and neurological examination findings are vital however to help differentiate other diffuse pathologies involving the cerebellum such as rhombencephalitis. Presented here are two diffuse cerebellar gliomas in children under the age of 3 with near identical imaging phenotypes demonstrating differing histological and molecular genetic profiles.


Assuntos
Neoplasias Encefálicas , Neoplasias Cerebelares , Glioma , Síndrome do Hamartoma Múltiplo , Humanos , Neoplasias Cerebelares/diagnóstico por imagem , Neoplasias Cerebelares/genética , Imageamento por Ressonância Magnética , Cerebelo/diagnóstico por imagem , Glioma/diagnóstico por imagem , Glioma/genética , Glioma/patologia , Neoplasias Encefálicas/patologia , Síndrome do Hamartoma Múltiplo/genética , Síndrome do Hamartoma Múltiplo/patologia , Síndrome do Hamartoma Múltiplo/cirurgia
2.
Int J Audiol ; : 1-6, 2022 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-36384381

RESUMO

OBJECTIVES: Conducting research in clinical settings is challenging. The aim of this study was to increase our understanding of hearing care professionals' perceptions of barriers to participating in such research. DESIGN: A modified group concept mapping approach was used to gain anonymous responses from 124 hearing care professionals to the statement: "One reason why it is hard to conduct intervention research studies in my centre/practice is….". Participants were asked for reasons other than 'time' as this is universally reported as a barrier to clinical research. RESULTS: A total of 107 distinct reasons were provided by participants and these were sorted into 5 clusters: "Competing demands/pressures" (18 statements), "Not a priority for management/organisation" (14 statements), "Lack of opportunity/support" (19 statements), "Clinician's knowledge, confidence, and beliefs" (24 statements), and "Recruitment/adherence to protocols is challenging" (32 statements). Identified barriers were generally similar to those reported in other healthcare settings, with unique barriers being those associated with a fear of scrutiny and lack of trust in the "academic elite". CONCLUSION: Findings highlight the importance of researchers, clinicians, and clinic managers working together at all stages of the research process in order for clinical research to be successful.

3.
Neurosurg Rev ; 44(5): 2425-2432, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-33340053

RESUMO

Cavum septum pellucidum (CSP) and cavum vergae (CV) cysts are commonly found incidentally. They are usually asymptomatic but may present with symptoms related to obstructive hydrocephalus. There is no consensus about the management of symptomatic CSP and CV cysts. We present, to the best of our knowledge, the first systematic review of the different treatment options for symptomatic CSP and CV cysts. We conducted a literature review using PubMed database, searching for cases of symptomatic CSP and CV cysts managed surgically, and published until April 2019. Preoperative characteristics, surgical procedure, and postoperative outcome were analyzed using SPSS® software (Statistical Package for Social Sciences, IBM®). We found 54 cases of symptomatic CSP and CV cysts managed surgically (34 males, 20 females, 1.7/1 male to female ratio). Mean age was 24.3 ± 20.1 years. The most common presentation was headaches (34 patients, 62%), followed by psychiatric symptoms (27 patients, 49.1%). Preoperative radiological hydrocephalus was present in 30 patients (54.5%). The most common surgical procedure was endoscopic fenestration (39 patients, 70.9%), followed by shunting (10 patients, 18.2%), open surgery (3 patients, 5.5%), and stereotactic fenestration (1 patient, 1.8%). Complete resolution of symptoms was achieved in 36 patients (65.5%) and partial resolution in 7 patients (12.7%), and symptoms were unchanged in 2 patients. The present review suggests that surgical treatment could provide resolution of the symptoms in most of the cases, regardless of the procedure performed. Although mean follow-up was short among the studies, recurrence rate was low.


Assuntos
Cistos do Sistema Nervoso Central , Cistos , Hidrocefalia , Adulto , Cistos do Sistema Nervoso Central/cirurgia , Feminino , Humanos , Hidrocefalia/etiologia , Hidrocefalia/cirurgia , Masculino , Recidiva Local de Neoplasia , Septo Pelúcido/diagnóstico por imagem , Septo Pelúcido/cirurgia , Adulto Jovem
4.
J Interprof Care ; 35(2): 301-309, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-32013642

RESUMO

Interprofessional collaboration is critical for optimal healthcare. Preparing for a collaborative, practice-ready workforce, the Interprofessional Learning Competencies (IPLCs) were adopted for accreditation of Australian entry-level health, nursing and medical tertiary training programs. In order to meet new accreditation standards, activities which facilitate and assess IPLC attainment must be identified. Interprofessional education programs have not evaluated student interprofessional learning activities using the Australian IPLCs. This project evaluates students' experiences of the IPLCs during 'Inspiring Health,' a community-based interprofessional placement, and determines whether reflections can effectively assess IPLC attainment. Forty-nine students from seven Flinders University health and social science programs completed written reflections about four self-selected IPLCs. The results indicated that students had opportunities to attain all the IPLCs. Their reflections were analyzed using thematic analysis. Three themes were identified: the processes by which students learned, the outcomes of their learning, and the factors that influenced their learning. Ultimately, these findings describe a beneficial community-based interprofessional learning activity for attainment of the Australian IPLCs and provide evidence that student reflections can be used to assess the Australian IPLCs.


Assuntos
Relações Interprofissionais , Aprendizagem , Austrália , Atenção à Saúde , Humanos
5.
Int J Audiol ; 59(1): 54-60, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31566461

RESUMO

Objective: The objective of the study was to discover the nature of parental lived experiences of the diagnostic process of Permanent Childhood Hearing Loss (PCHL) and to construct an emotional life-world of parent experience around PCHL.Design: Through an Interpretive Phenomenological Analytical (IPA) framework and subsequent purposive sampling, parents were invited to semi-structured interviews.Sample: Ten parents of children who were identified with PCHL as one or the only permanent childhood disability diagnosed during early childhood were interviewed.Results: Five themes emerged; (a) a received disability, (b) casualties, (c) acceptance in real-time, (d) the unique signature of family life, and (e) audiologists are essential and appreciated guides. The emotional landscape chronicled two concurrent, non-linear affective groupings: the spiral of disorientation, and protective states of righting.Conclusion: Parents require a level of emotional support that exceeds frameworks of counselling. We propose the Dual Process Model as an intermediary model of emotional literacy to address both grieving and coping during the passage from diagnosis to early management. We believe it provides an effortless articulation with the principles of Family-Centred Care philosophies (top down) and behaviours (bottom up) by providing a taxonomy of grieving, coping and parents' movement between the two orientations.


Assuntos
Adaptação Psicológica , Surdez/psicologia , Pesar , Pais/psicologia , Adulto , Criança , Pré-Escolar , Surdez/diagnóstico , Feminino , Humanos , Lactente , Masculino , Pesquisa Qualitativa
6.
Acta Neurochir (Wien) ; 160(5): 885-891, 2018 05.
Artigo em Inglês | MEDLINE | ID: mdl-29546554

RESUMO

OBJECTIVE: To compare the long-term outcomes of patients who had been randomly allocated to receive primary titanium cranioplasty or autologous bone graft following decompressive craniectomy. METHODS: Sixty-four patients had been previously enrolled and randomised to receive either their own bone graft or a primary titanium cranioplasty. Functional and cosmetic outcomes had previously been assessed at 1-year following the cranioplasty procedure. Hospital records and the Picture Archiving communication system were reviewed to determine how many patients had cranioplasty failure or associated complications such as seizures beyond 1 year-with a minimum of 24-month follow-up. RESULTS: Amongst the 31 patients in the titanium group (one patient had died), no patients had a partial or complete cranioplasty failure at 12 months follow-up and there had been no failures beyond 12 months. Amongst the 31 patients who had an autologous cranioplasty (one patient had died), 7 patients had complete resorption of the autologous bone such that it was adjudged a complete failure at 12-month follow-up. Five of these patients had had titanium augmentation and two patients declined further surgery. Both of these patients requested cranial augmentation for functional and cosmetic reasons subsequent to the 12-month follow-up. Another patient who had previously been noted to have moderate resorption at 12 months presented 1 year later with progressive bone flap resorption and also required subsequent augmentation for functional and cosmetic reasons. When follow-up was extended to a minimum of 24 months, use of titanium instead of autologous bone for primary cranioplasty resulted in a significant reduction in the number of patients who required rescue cranioplasty (0 vs 25%, 95% confidence interval [CI] 9.1-42.1%; p = 0.001). In addition, there were significantly less total hospital healthcare costs in those patients randomised to the titanium arm of the trial (difference = A$9999, 95%CI 2231-17,768; p = 0.015). CONCLUSIONS: Bone resorption continued to occur beyond 12 months after autologous cranioplasty; use of primary titanium cranioplasty after decompressive craniectomy reduced the number of reoperations needed and the associated long-term total hospital costs.


Assuntos
Transplante Ósseo/efeitos adversos , Craniectomia Descompressiva/efeitos adversos , Complicações Pós-Operatórias/epidemiologia , Adulto , Reabsorção Óssea/etiologia , Transplante Ósseo/métodos , Craniectomia Descompressiva/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/cirurgia , Reoperação/estatística & dados numéricos , Retalhos Cirúrgicos/efeitos adversos , Titânio/efeitos adversos , Transplante Autólogo
7.
Int J Lang Commun Disord ; 53(3): 564-575, 2018 05.
Artigo em Inglês | MEDLINE | ID: mdl-29341359

RESUMO

BACKGROUND: Language and memory impairments affect everyday interactions between individuals with dementia and their communication partners. Impaired topic management, which compromises individuals' construction of relevant, meaningful discourse, is commonly reported amongst individuals with dementia. Currently, limited empirical evidence describes the sequential patterns of behaviour comprising topic-management practices in everyday conversation between individuals with dementia and their communication partners. AIMS: To describe the sequential patterns of behaviour relating to the manifestation of topic-management impairments and facilitative behaviours in everyday interactions between individuals with dementia and their familiar communication partners (FCPs). METHODS & PROCEDURES: Three 20-min conversations between individuals with moderate to severe dementia and their FCPs were recorded. Conversation Analysis was used to examine sequences in which topic-management appeared to be impaired. OUTCOMES & RESULTS: Conversational behaviours that reflected a difficulty in contributing on-topic talk were pervasive in the talk of the three individuals with dementia. FCPs responded to these conversational difficulties by using two categories of facilitative behaviours. The first involved responding to an individual with dementia's explicit repair-initiation by performing repair. In the second category, explicit repair-initiation was absent; instead, the distance of the conversational difficulty from the prior topic-shifting turn mediated the form and outcome of the FCPs' facilitative behaviours. Each category successfully facilitated the individual with dementia to contribute on-topic talk. CONCLUSIONS & IMPLICATIONS: The findings contribute to a growing understanding of topic-management abilities in everyday interactions involving individuals with dementia. Individuals with dementia took a proactive role in eliciting topic-management support. The FCPs responded with turns that facilitated the individuals with dementia to talk on-topic. Clinically, the results support and extend the current topic-management recommendations available in communication partner training programmes, and promote conversations which attend to the personhood of the individual with dementia.


Assuntos
Comunicação , Demência/psicologia , Relações Familiares/psicologia , Relações Interpessoais , Reconhecimento Psicológico , Idoso , Idoso de 80 Anos ou mais , Compreensão , Feminino , Humanos , Idioma , Masculino
8.
J Manipulative Physiol Ther ; 41(2): 111-122, 2018 02.
Artigo em Inglês | MEDLINE | ID: mdl-29482826

RESUMO

OBJECTIVES: The purpose of this study was to assess the use of computer-aided combined movement examination (CME) to measure change in low back movement after neurosurgical intervention for lumbar spondylosis and to use a CME normal reference range (NRR) to compare and contrast movement patterns identified from lumbar disk disease, disk protrusion, and nerve root compression cases. METHODS: A test-retest, cohort observational study was conducted. Computer-aided CME was used to record lumbar range of motion in 18 patients, along with pain, stiffness, disability, and health self-report questionnaires. A minimal clinically important difference of 30% was used to interpret meaningful change in self-reports. z Scores were used to compare CME. Post hoc observation included subgrouping cases into 3 discrete pathologic conditions-disk disease, disk protrusion, and nerve root compression-to report intergroup differences in CME. RESULTS: Self-report data indicated that 11, 7, and 10 patients improved by ≥30% in pain, stiffness, and function, respectively. Three patients experienced clinically significant improvement in health survey. A CME pattern reduced in all directions suggested disk disease. Unilaterally restricted movement in side-flexed or extended directions suggested posterolateral disk protrusion with or without ipsilateral nerve root compression. Bilateral restrictions in extension suggested posterior disk protrusion with or without nerve root compression. In 11 of the 18 cases, CME converged toward the NRR after surgery. CONCLUSION: We described the use of CME to identify atypical lumbar movement relative to an NRR. Data from this short-term postoperative study provide preliminary evidence for CME movement patterns suggestive of disk disease, disk protrusion, and nerve root compression.


Assuntos
Diagnóstico por Computador/métodos , Disco Intervertebral/fisiopatologia , Vértebras Lombares/fisiopatologia , Região Lombossacral/fisiopatologia , Radiculopatia/fisiopatologia , Adulto , Estudos de Coortes , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Movimento , Medição da Dor/métodos , Amplitude de Movimento Articular , Inquéritos e Questionários
9.
J Manipulative Physiol Ther ; 40(5): 340-349, 2017 06.
Artigo em Inglês | MEDLINE | ID: mdl-28413117

RESUMO

OBJECTIVE: A test-retest cohort study was conducted to assess the use of a novel computer-aided, combined movement examination (CME) to measure change in low back movement after pain management intervention in 17 cases of lumbar spondylosis. Additionally we desired to use a CME normal reference range (NRR) to compare and contrast movement patterns identified from 3 specific structural pathologic conditions: intervertebral disc, facet joint, and nerve root compression. METHODS: Computer-aided CME was used before and after intervention, in a cohort study design, to record lumbar range of movement along with pain, disability, and health self-report questionnaires in 17 participants who received image-guided facet, epidural, and/or rhizotomy intervention. In the majority of cases, CME was reassessed after injection together with 2 serial self-reports after an average of 2 and 14 weeks. A minimal clinically important difference of 30% was used to interpret meaningful change in self-reports. A CME NRR (n = 159) was used for comparison with the 17 cases. Post hoc observation included subgrouping cases into 3 discrete pathologic conditions, intervertebral disc, facet dysfunction, and nerve root compression, in order to report intergroup differences in CME movement. RESULTS: Seven of the 17 participants stated that a "combined" movement was their most painful CME direction. Self-report outcome data indicated that 4 participants experienced significant improvement in health survey, 5 improved by ≥30% on low back function, and 8 reported that low back pain was more bothersome than stiffness, 6 of whom achieved the minimal clinically important difference for self-reported pain. Subgrouping of cases into structure-specific groups provided insight to different CME movement patterns. CONCLUSION: The use of CME assists in identifying atypical lumbar movement relative to an age and sex NRR. Data from this study, exemplified by representative case studies, provide preliminary evidence for distinct intervertebral disc, facet joint, and nerve root compression CME movement patterns in cases of chronic lumbar spondylosis.


Assuntos
Diagnóstico por Computador/métodos , Vértebras Lombares/fisiopatologia , Medição da Dor/métodos , Radiculopatia/fisiopatologia , Adulto , Estudos de Coortes , Humanos , Região Lombossacral/fisiopatologia , Pessoa de Meia-Idade , Manejo da Dor
10.
Int J Audiol ; 55 Suppl 3: S13-22, 2016 07.
Artigo em Inglês | MEDLINE | ID: mdl-26750770

RESUMO

OBJECTIVE: To explore the explanatory power of a self-determination theory (SDT) model of health behaviour change for hearing aid adoption decisions and fitting outcomes. DESIGN: A quantitative approach was taken for this longitudinal cohort study. Participants completed questionnaires adapted from SDT that measured autonomous motivation, autonomy support, and perceived competence for hearing aids. Hearing aid fitting outcomes were obtained with the international outcomes inventory for hearing aids (IOI-HA). Sociodemographic and audiometric information was collected. STUDY SAMPLE: Participants were 216 adult first-time hearing help-seekers (125 hearing aid adopters, 91 non-adopters). RESULTS: Regression models assessed the impact of autonomous motivation and autonomy support on hearing aid adoption and hearing aid fitting outcomes. Sociodemographic and audiometric factors were also taken into account. Autonomous motivation, but not autonomy support, was associated with increased hearing aid adoption. Autonomy support was associated with increased perceived competence for hearing aids, reduced activity limitation and increased hearing aid satisfaction. Autonomous motivation was positively associated with hearing aid satisfaction. CONCLUSION: The SDT model is potentially useful in understanding how hearing aid adoption decisions are made, and how hearing health behaviour is internalized and maintained over time. Autonomy supportive practitioners may improve outcomes by helping hearing aid adopters maintain internalized change.


Assuntos
Comportamento de Escolha , Correção de Deficiência Auditiva/instrumentação , Correção de Deficiência Auditiva/psicologia , Auxiliares de Audição , Transtornos da Audição/psicologia , Transtornos da Audição/terapia , Modelos Psicológicos , Aceitação pelo Paciente de Cuidados de Saúde , Autonomia Pessoal , Pessoas com Deficiência Auditiva/psicologia , Pessoas com Deficiência Auditiva/reabilitação , Adulto , Idoso , Idoso de 80 Anos ou mais , Audiometria , Percepção Auditiva , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Transtornos da Audição/diagnóstico , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Motivação , Participação do Paciente , Satisfação do Paciente , Qualidade de Vida , Inquéritos e Questionários , Resultado do Tratamento
11.
Int J Lang Commun Disord ; 51(6): 745-756, 2016 11.
Artigo em Inglês | MEDLINE | ID: mdl-27041673

RESUMO

BACKGROUND: Difficulty participating in conversation is commonly experienced by individuals with dementia, secondary to cognitive and language deficits. Frequent communication partners (FCPs), however, report being largely unaware of how to support their conversation partners with dementia during conversation. In particular, taking a turn appropriately may be difficult for either partner due to trouble predicting a partner's behaviour and, hence, difficulty with timing conversational turns appropriately, potentially resulting in overlapping talk. AIMS: To investigate the patterns of overlapping talk in the interaction between individuals with dementia and their FCPs. METHODS & PROCEDURES: Three participants with moderate-severe dementia participated in conversation with an FCP. Ten minutes of 'casual' and 'task-oriented' conversation were audio- and video-recorded. Patterns of overlapping talk were investigated using conversation analytic methods. OUTCOMES & RESULTS: Overlapping talk was a consistent feature of all three dyadic interactions during both social and task-oriented talk. All participants exhibited competitive and non-competitive forms of overlapping talk. The data reveal that FCPs commonly yielded their own turns when overlapped by a partner in order to create opportunities for their partners with dementia to communicate. Participants with dementia demonstrated some retained pragmatic abilities, both using continuers and yielding the floor to their partner when competitively overlapped in order to encourage a speaker to continue. CONCLUSIONS & IMPLICATIONS: These findings contribute to the understanding of the impact of dementia on the maintenance of sensitivity to the sequential aspects of everyday talk. From a clinical perspective, these findings can inform the training of FCPs about retained abilities and evidence-based support strategies, equipping them with knowledge and skills to structure and maintain fluent conversation.


Assuntos
Comunicação , Demência/psicologia , Relações Interpessoais , Compreensão , Humanos , Idioma
13.
Int J Audiol ; 54(7): 476-84, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25766490

RESUMO

OBJECTIVE: To use the self-determination theory of motivation to investigate whether different forms of motivation were associated with adults' decisions whether or not to adopt hearing aids. DESIGN: A quantitative approach was used in this cohort study. Participants completed the treatment self-regulation questionnaire (TSRQ), which measured autonomous and controlled motivation for hearing aid adoption. Sociodemographic data and audiometric information were also obtained. STUDY SAMPLE: Participants were 253 adults who had sought information about their hearing but had not consulted with a hearing professional. Participants were categorized as hearing aid adopters if they had been fitted with hearing aids 4-6 months after completing the TSRQ, and as non-adopters if they had not. RESULTS: Multivariate logistic regression was used to examine associations between autonomous and controlled motivation, sociodemographic and audiometric variables, and hearing aid adoption (n = 160). Three factors were significantly associated with increased hearing aid adoption when the influence of other variables was accounted for: autonomous motivation, perceived hearing difficulty, and poorer hearing. Controlled motivation was not found to influence hearing aid adoption. CONCLUSION: These empirical findings that link autonomous motivation to decisions of hearing help-seekers have implications for the ways practitioners may evaluate motivation and could inform discussions with clients about hearing aid adoption.


Assuntos
Correção de Deficiência Auditiva/psicologia , Auxiliares de Audição/psicologia , Perda Auditiva/psicologia , Motivação , Aceitação pelo Paciente de Cuidados de Saúde/psicologia , Idoso , Idoso de 80 Anos ou mais , Estudos de Coortes , Correção de Deficiência Auditiva/instrumentação , Feminino , Perda Auditiva/reabilitação , Testes Auditivos , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Autoimagem , Fatores Socioeconômicos , Inquéritos e Questionários
14.
Int J Audiol ; 54(6): 368-75, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25544358

RESUMO

OBJECTIVE: This study investigated whether young adults (between 18 and 30 years at the time of the project) who were assessed for auditory processing disorder (APD) in childhood (between 7 and 16 years) experience persistence of listening and communication difficulties. DESIGN: Participants completed a mixed methods questionnaire focusing on common areas of complaint in APD and two open-ended questions exploring participants' past and present experiences with listening and communication difficulties. STUDY SAMPLE: Ninety-seven of the 722 potential participants returned completed questionnaires, of whom 66 had been diagnosed with APD (APD group) at the time of their auditory processing assessment and 31 had not met diagnostic criteria (NAPD group) at that time. RESULTS: Substantial commonality was noted in the reported listening and communication difficulties between the APD and NAPD participants. Volunteered comments aggregated into four major content themes which included: listening and communication difficulties; participants' sense of self; change; and participation. Members of the APD group reported greater communication difficulty than NAPD group members, irrespective of environmental listening conditions. CONCLUSIONS: Young adults with a prior referral for, and in some cases a diagnosis of, APD as children continue to experience auditory processing difficulties across a range of daily situations.


Assuntos
Percepção Auditiva , Transtornos da Percepção Auditiva/complicações , Transtornos da Comunicação/epidemiologia , Adolescente , Adulto , Transtornos da Percepção Auditiva/diagnóstico , Transtornos da Percepção Auditiva/psicologia , Criança , Estudos de Coortes , Transtornos da Comunicação/etiologia , Feminino , Seguimentos , Humanos , Masculino , Qualidade de Vida , Autoimagem , Inquéritos e Questionários , Fatores de Tempo , Adulto Jovem
15.
J Anat ; 224(2): 95-107, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-24138151

RESUMO

The caudal zona incerta is the target of a recent modification of established procedures for deep brain stimulation (DBS) for Parkinson's disease and tremor. The caudal zona incerta contains a number of neuronal populations that are distinct in terms of their cytoarchitecture, connections, and pattern of immunomarkers and is located at a position where a number of major tracts converge before turning toward their final destination in the forebrain. However, it is not clear which of the anatomical features of the region are related to its value as a target for DBS. This paper has tried to identify features that distinguish the caudal zona incerta of rodents (mouse and rat) and primates (marmoset, rhesus monkey, and human) from the remainder of the zona incerta. We studied cytoarchitecture, anatomical relationships, the pattern of immunomarkers, and gene expression in both of these areas. We found that the caudal zona incerta has a number of histological and gene expression characteristics that distinguish it from the other subdivisions of the zona incerta. Of particular note are the sparse population of GABA neurons and the small but distinctive population of calbindin neurons. We hope that a clearer appreciation of the anatomy of the region will in the end assist the interpretation of cases in which DBS is used in human patients.


Assuntos
Subtálamo/anatomia & histologia , Subtálamo/citologia , Anatomia Comparada , Animais , Callithrix , Estimulação Encefálica Profunda/métodos , Expressão Gênica , Humanos , Imuno-Histoquímica , Macaca mulatta , Camundongos , Doença de Parkinson , Primatas , Ratos , Especificidade da Espécie , Núcleo Subtalâmico/anatomia & histologia , Núcleo Subtalâmico/citologia
16.
Chemistry ; 19(50): 17097-102, 2013 Dec 09.
Artigo em Inglês | MEDLINE | ID: mdl-24194455

RESUMO

In this paper we describe a new class of antiaromatic planar cyclooctatetraenes: the diazadioxa[8]circulenes. The synthesis was achieved by means of a new acid-mediated oxidative dimerization of 3,6-dihydroxycarbazoles to yield the diazadioxa[8]circulenes in high yields. The synthetic protocol appears to be general, and is a one-pot transformation in which two C-C bonds and two C-O bonds are formed with the loss of two molecules of water. We also present a detailed characterization of the optical and electrochemical properties of this new class of stable planar cyclooctatetraenes. The properties of the diazadioxa[8]circulenes are compared with the properties of isoelectronic tetraoxa[8]circulenes and azatrioxa[8]circulenes. We discuss the antiaromatic nature of the planar central cyclooctatetraene moiety. The antiaromatic nature of the planar cyclooctatetraenes was studied by using computational methods (NICS calculations), and these calculations reveal that the central eight-membered ring has antiaromatic character.

17.
J Med Ethics ; 38(11): 657-61, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-22807572

RESUMO

In all fields of clinical medicine, there is an increasing awareness that outcome must be assessed in terms of quality of life and cost effectiveness, rather than merely length of survival. This is especially the case when considering decompressive craniectomy for severe traumatic brain injury. The procedure itself is technically straightforward and involves temporarily removing a large section of the skull vault in order to provide extra space into which the injured brain can expand. A number of studies have demonstrated many patients going on to make a good long-term functional recovery, however, this is not always the case and a significant number survive but are left with severe neurocognitive impairment. Unfortunately, many of these patients are young adults who were previously fit and well and are, therefore, likely to spend many years in a condition that they may feel to be unacceptable, and this raises a number of ethical issues regarding consent and resource allocation. In an attempt to address these issues, we have used the analytical framework proposed by Jonsen, that requires systematic consideration of medical indications, patient preferences, quality of life and contextual features.


Assuntos
Lesões Encefálicas/cirurgia , Craniectomia Descompressiva/ética , Consentimento Livre e Esclarecido , Qualidade de Vida , Adulto , Austrália , Efeitos Psicossociais da Doença , Análise Custo-Benefício , Craniectomia Descompressiva/normas , Ética Médica , Recursos em Saúde/estatística & dados numéricos , Humanos , Escala de Gravidade do Ferimento , Autonomia Pessoal , Anos de Vida Ajustados por Qualidade de Vida , Medição de Risco , Resultado do Tratamento
18.
Int J Audiol ; 51(1): 43-53, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22103401

RESUMO

OBJECTIVE: With increasing focus on the consequences of aural rehabilitation for the everyday conversational difficulties arising from adult acquired hearing impairment, this study aimed to compare patterns of repair behaviour arising in conversation and a widely used aural rehabilitation tool, continuous discourse tracking (de Filippo & Scott, 1978), in order to better understand the procedure's role in the assessment and training of repair behaviour. DESIGN: A parallel case study design was adopted. Communication dyads undertook a 20-minute conversation followed by a 20-minute session of tracking. The interactions were audio-recorded, transcribed, and analysed for patterns of repair according to current conversation analytic conventions (Schegloff et al, 1977). The research questions were addressed via both qualitative and quantitative methods. STUDY SAMPLE: Three communication pairs (dyads), each comprising an adult with acquired hearing impairment and their chosen familiar communication partner, participated in this study. RESULTS: Analysis revealed that patterns of repair were constrained by the task requirement in tracking for the receiver/hearing-impaired adult to repeat text segments spoken by the sender/familiar communication partner with 100% accuracy. CONCLUSIONS: Whilst tracking has a number of useful conversational qualities, it may have only limited ecological validity when applied to the evaluation and training of repair behaviour.


Assuntos
Comunicação , Correção de Deficiência Auditiva , Sinais (Psicologia) , Transtornos da Audição/terapia , Pessoas com Deficiência Auditiva/reabilitação , Percepção da Fala , Idoso , Idoso de 80 Anos ou mais , Compreensão , Correção de Deficiência Auditiva/psicologia , Feminino , Transtornos da Audição/psicologia , Humanos , Masculino , Pessoa de Meia-Idade , Pessoas com Deficiência Auditiva/psicologia , Medida da Produção da Fala
19.
Scand J Pain ; 22(1): 48-58, 2022 01 27.
Artigo em Inglês | MEDLINE | ID: mdl-34333881

RESUMO

OBJECTIVES: The study aimed to investigate if patients with lumbar radicular pain only and those with combined lumbar radicular pain + radiculopathy differ in their somatosensory profiles and pain experiences. METHODS: Quantitative sensory testing (QST) was performed in 26 patients (mean age 47 ± 10 years, 10 females) with unilateral leg pain in the L5 or S1 distribution in their main pain area (MPA) and contralateral mirror side, in the relevant foot dermatome on the symptomatic side and in the hand dorsum. Pain experience was captured on the painDETECT. RESULTS: Eight patients presented with lumbar radicular pain only and 18 patients with combined radicular pain + radiculopathy. Patients with radicular pain only demonstrated widespread loss of function (mechanical detection) bilaterally in the MPA (p<0.003) and hand (p=0.002), increased heat sensitivity in both legs (p<0.019) and cold/heat sensitivity in the hand (p<0.024). QST measurements in the dermatome did not differ compared to HCs and patients with radiculopathy. Patients with lumbar radiculopathy were characterised by a localised loss of function in the symptomatic leg in the MPA (warm, mechanical, vibration detection, mechanical pain threshold, mechanical pain sensitivity p<0.031) and dermatome (mechanical, vibration detection p<0.001), consistent with a nerve root lesion. Pain descriptors did not differ between the two groups with the exception of numbness (p<0.001). Patients with radicular pain did not report symptoms of numbness, while 78% of patients with radiculopathy did. CONCLUSIONS: Distinct differences in somatosensory profiles and pain experiences were demonstrated for each patient group, suggesting differing underlying pain mechanisms.


Assuntos
Dor Lombar , Radiculopatia , Ciática , Adulto , Feminino , Humanos , Pessoa de Meia-Idade , Medição da Dor , Limiar da Dor , Radiculopatia/diagnóstico
20.
Audiol Res ; 12(6): 620-634, 2022 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-36412655

RESUMO

This study aimed to explore the experiences of adult clients with hearing loss and their audiologists in using an online tool, the Living Well Tool (LWT), during initial audiology appointments. The LWT is designed to help clients identify when and where it is most important for them to communicate effectively and live well with hearing loss. A total of 24 adult clients with hearing loss and two audiologists participated in this study. Clients were invited to complete the LWT prior to their next audiology appointment, however, most clients chose to use the LWT in-session with their audiologist. Following the appointment, clients and audiologists participated in individual qualitative semi-structured interviews to explore their experiences of using the LWT, and the extent to which the LWT facilitated person-centred care. Qualitative analysis five key themes which reflected participants' experiences and perceptions of using the LWT: (1) the LWT enhances audiological care; (2) the LWT supports person-centred audiological care; (3) the use of the LWT should be individualised; (4) users value comprehensiveness; and (5) users value accessibility. This study demonstrated that the LWT supported the provision of person-centred audiological care, providing a flexible, comprehensive and accessible means for audiologists to gain an understanding of their clients' needs and preferences. However, it was also noted that the use of a tool must be individualised and accessible for all.

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