Prevalence of and risk factors for metabolic associated fatty liver disease in an urban population in China: a cross-sectional comparative study.

BACKGROUND: Metabolic associated fatty liver disease (MAFLD) is a new definition for liver disease associated with known metabolic dysfunction. Based on new diagnostic criteria, we aimed to investigate its prevalence and risk factors in Chinese population. METHODS: We conducted this study in a health examination population who underwent abdominal ultrasonography in China. The diagnosis of MAFLD was based on the new diagnostic criteria. The characteristics of the MAFLD population, as well as the associations between MAFLD and metabolic abnormalities, were explored. Mann-Whitney U test and chi-square test were performed to compare different variables. Binary logistic regression was used to determine the risk factors for MAFLD. RESULTS: Among 139,170 subjects, the prevalence of MAFLD was 26.1% (males: 35.4%; females: 14.1%). The prevalence based on female menopausal status, that is, premenopausal, perimenopausal, and postmenopausal, was 6.1%, 16.8%, and 30.2%, respectively. In different BMI groups (underweight, normal, overweight and obese), the prevalence was 0.1%, 4.0%, 27.4% and 59.8%, respectively. The proportions of abnormal metabolic features in the MAFLD group were significantly higher than those in the non-MAFLD group, as was the proportion of elevated alanine aminotransferase (ALT) (42.5% vs. 11%, P < 0.001). In nonobese individuals with MAFLD, the proportions of abnormal metabolic features were also all significantly higher than those in nonobese individuals without MAFLD. The prevalence of metabolic syndrome (MS), dyslipidaemia, and hyperuricaemia, respectively, in the MAFLD group (53.2%, 80.0%, and 45.0%) was significantly higher than that in the non-MAFLD group (10.1%, 41.7%, and 16.8%). Logistic regression revealed that age, BMI, waist circumference, ALT, triglycerides, fasting glucose, uric acid and platelet count were associated with MAFLD. CONCLUSIONS: MAFLD is prevalent in China and varies considerably among different age, sex, BMI, and female menopausal status groups. MAFLD is related to metabolic disorders, especially obesity, while metabolic disorders also play important roles in the occurrence of MAFLD in nonobese individuals. MAFLD patients exhibit a high prevalence of MS, dyslipidaemia, hyperuricaemia, and elevated liver enzymes. MAFLD tends to coexist with systemic metabolic disorders, and a deep inner relationship may exist between MAFLD and MS. Metabolic disorders should be considered to improve the management of MAFLD.

Relationship between the Metabolic Associated Fatty Liver Disease and Endometrial Thickness in Postmenopausal Women: A Cross-sectional Study in China.

Objectives: To determine the relationship between the endometrial thickness (ET) and metabolic associated fatty liver disease (MAFLD) in the postmenopausal women who have a comprehensive health examination. Methods: This was a population-based, retrospective observational study of the prevalence of MAFLD in 8594 postmenopausal women with different ET in the Quality Control Center of Health Examination in Chongqing, China. Binary and multivariable logistic regression analyses were used to obtain odds ratios and 95% confidence intervals for patients of different ET with MAFLD after adjusting for age. Results: The incidences of MAFLD were 28.6% (1352), 30.3% (1058), 34.9% (133) in postmenopausal women with ET of < 3 mm, 3 mm ≤ & < 5 mm, and ≥ 5 mm, respectively. Compared with a baseline ET of less than 5.0 mm, the risk of MAFLD in patients with ET of ≥5.0 mm is higher (OR=1.291, 95% CI: 1.041-1.603, P<0.05). After adjustment for age, a statistically significant positive correlation was still observed. The increased prevalence of MAFLD in patients with ET of 3 mm ≤ &<5 mm (OR=1.110, 95% CI: 1.008-1.223) and ≥5 mm (OR=1.383, 95% CI: 1.109-1.724) achieved statistical significance, respectively. In addition, multiple logistic analyses controlling for age also confirmed the finding of positive correlation among body mass index (BMI) and ET. Conclusion: Our results suggest that there is a positive correlation between MAFLD and ET in postmenopausal women. In addition, increased BMI is also associated with an increased risk of thickened endometrium.

Status of lipid and lipoprotein in female breast cancer patients at initial diagnosis and during chemotherapy.

BACKGROUND: The lipid profile status among breast cancer patients at initial diagnosis and during chemotherapy remain controversial. The aim of this study is to study the status of lipid and lipoprotein in female breast cancer patients at initial diagnosis and during chemotherapy. METHODS: We conducted a retrospective cohort study of the status of the lipid and lipoprotein in 1054 primarily diagnosed breast cancer patients and 2483 normal controls with age stratification, from July 2015 to October 2016. At the same time, the status of lipid and lipoprotein were also analyzed among 394 breast cancer patients before and after adjuvant chemotherapy. RESULTS: The incidence of dyslipidemia was significantly lower in breast cancer group(42.98%) compared to normal group(58.28%)(P < 0.001). The levels of total cholesterol (TC), triglycerides (TG), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C) among breast cancer group were significantly lower compared to normal control group (P < 0.05). With age stratification, the levels of TC and LDL-C in breast cancer group were still significantly lower than those in control group (P < 0.001). And the levels of TC, TG, LDL-C, apolipoprotein B were significantly higher among post chemotherapeutic patients compared to prechemotherapeutic patients, however HDL-C and Apo-A1 levels were contrary. CONCLUSIONS: Breast cancer patients have lower incidence of dyslipidemia compared to normal populations. However, the situation of dyslipidemia may become worsened after chemotherapy. Therefore, lipid monitoring and dyslipidemia prevention and treatment should be conducted for breast cancer patients at initial diagnosis and during chemotherapy.

[Preparation of δ-Valerolactone and Its Spectral Analysis].

In the study, CuO/ZnO/Al2O3 was prepared by sol-gel method. Its catalytic activity was evaluated by gas-phase catalytic dehydrogenation of 1, 5-Pentanediol to δ-valerolactone as a probe reaction. CuO/ZnO/Al2O3 and long period reactive CuO/ZnO/Al2O3 were detected by XRD. Micro-structure and essence disciplinarian of CuO/ZnO/Al2O3 were disclosed. Metal ions had a cooperative effects during the catalytic dehydrogenation of 1, 5-pentanediol to δ-valerolactone. After CuO/ZnO/Al2O3 deactivation, crystal particle size was increased clearly. It were found that characteristic diffraction peaks were caused by the catalyst temperature raising in methanol catalytic synthesis of ZnO. 1, 5-Pentanediol and δ-valerolactone were detected by FTIR. Their internal chemical bond and molecular structure were disclosed. The purity of δ-valerolactone product was very high. δ-Valerolactone and its polymer were detected by DSC. δ-Valerolactone possessed with poor stability. Polymerization reaction was easily happened by itself. So it was worth focusing on how to improve the stability of the δ-valerolactone monomer. This study could provide basic data and experimental basis for gas-phase catalytic dehydrogenation of 1, 5-Pentanediol to δ-valerolactone in pilot and industrial scale up research.

E-cadherin gene methylation in lung cancer.

E-cadherin, a tumor repressor gene, has been shown to play an important role in maintaining the polarity and structural integrity of epithelial and is closely associated with tumorigenesis, invasion, and metastasis. The current study aimed to investigate the effects of E-cadherin methylation on lung cancer (LC) quantitatively through a meta-analysis. We searched electronic databases to identify eligible studies from their inception through September 30, 2013. Pooled odds ratio (OR) with 95 % confidence interval (CI) was used to assess the relationship between E-cadherin gene methylation and LC risk. A hazard ratio (HR) with 95 % CI was used to assess the impact of E-cadherin gene methylation on overall survival (OS) of LC patients. Seventeen studies comprising 983 LC cases and 669 controls met the inclusion criteria. Summary results revealed that hypermethylation frequencies in LC tissues were significantly higher than those in normal control tissues (OR = 4.11, 95 % CI 2.78-6.07, P < 0.001). Subgroup analysis indicated that higher methylation frequencies were observed in Asian population. Interestingly, we found that hypermethylation of E-cadherin was associated with significantly better survival with HR of 0.47 (95 % CI 0.31-0.71). This meta-analysis revealed that E-cadherin gene promoter methylation was associated with an increased risk of LC, especially in Asian population, and methylated E-cadherin predicted long survival in patients with LC. However, further studies with large numbers of patients will be needed to confirm the findings.

An Observational and Cross-Sectional Study of the Prevalence of Breast Lesions and Metabolic Dysfunction-Associated Fatty Liver Disease and their Relationship in China.

BACKGROUND AND AIMS: Metabolic dysfunction-associated fatty liver disease (MAFLD) has been proposed to replace the concept of non-alcoholic fatty liver disease (NAFLD). The relationship between MAFLD and breast lesions has not been reported. Therefore, we aimed to explore their prevalence and relationship among general population. METHODS: This cross-sectional study was conducted in the First Affiliated Hospital of Chongqing Medical University. After considering the exclusion criteria, 46,547 consecutive women who synchronously accepted breast and abdominal ultrasonography during one physical check-up between January 2015 and September 2018 were enrolled in this study. Prevalence of breast masses (BM), BI-RADS categories breast lesions and MAFLD in general population were revealed and the association between MAFLD and breast mass, BI-RADS categories breast lesions was analyzed by conducting logistic regression models. RESULTS: Of 46,547 participants, 8,020 (17.23%) had BM, 6,345 (13.63%) had MAFLD. Women with MAFLD had a lower BM prevalence than those without MAFLD (11.87% vs.18.08%; p<0.001). Overall, women with MAFLD had a lower risk of BM compared to those without MAFLD (adjusted OR=0.849, 95%CI: 0.775-0.930, p<0.001). Analysis based on BI-RADS categories breast lesions demonstrated that MAFLD is negatively related to BI-RADS 2/3 categories breast lesions (BI-RADS 2 category adjusted OR=0.980, 95%CI: 0.906-1.061, p=0.626; BI-RADS 3 category adjusted OR=0.736, 95%CI: 0.641-0.845, p=0.001), while associated with higher risk of BI-RADS ≥4 categories breast lesions (adjusted OR=1.220, 95%CI: 1.005-1.480, p=0.044). Subgroup analysis across age (18-44, 45-54 and≥55 years old) and body mass index (<25 and ≥25kg/m2) demonstrated that MAFLD was negatively associated with BI-RADS 2/3 categories breast lesions in premenopausal and perimenopausal women, and positively associated with BI-RADS ≥4 categories breast lesions in postmenopausal women, whether in obese or not. CONCLUSIONS: MAFLD was inversely associated with BM and BI-RADS 2/3 categories breast lesions in premenopausal and perimenopausal women, irrespective of obesity presence; MAFLD increased the risk of BM and BI-RADS ≥4 categories breast lesions in postmenopausal women.

[Study on CuO-CeO2 catalysts doped with alkali and alkaline earth metal oxides by in-situ DRIFTS].

CuO-CeO2 series catalysts are the effective catalysts for the selective CO oxidation in hydrogen-rich gas. The adsorption species on the CuO-CeO2 catalysts doped with alkali and alkaline earth metal oxides were investigated with in situ diffuse reflectance FTIR spectroscopy (in-situ DRIFTS) technique. The results showed that a bane at 2 106 cm(-1), due to the carbonyl species, appeared on the CuO-CeO2 catalysts. In the reaction atmosphere, the intensity of this band increased first and then decreased with increasing the temperatures. It was noted that the main active adsorption sites of the CuO-CeO2 catalysts were Cu+ species. At lower temperatures, the carbonyl species were desorbed from the surface of CuO-CeO2 catalysts in the reversible form, while they were desorbed mainly in the irreversible form at the higher temperatures. A sharp peak at 3 660 cm(-1), attributed to the geminal Ce(OH)2 group, was also apparent on the surface of reduced CuO-CeO2 catalyst. The peaks at 1 568, 2 838 and 2 948 cm(-1) were attributed to formate species and the peaks centered at 1 257 and 1 633 cm(-1) were assigned to carbonate species. CO could react with the active hydroxyl species and generate formate species. At higher temperatures, the C-H bond of formate species could break and form carbonate species. These two species would decrease the performance of CuO-CeO2 catalysts at higher temperatures. The stronger IR peaks attributed to CO2 and formate species were observed, moreover there was still a weak IR peak assigned to carbonyl species for Cu1 Li1 Ce9Odelta catalyst when the temperature was above 180 degrees C. It was shown that as the electron donor, the doping of Li2 O on CuO-CeO2 catalyst could contribute to the irreversible desorption of CO at lower temperatures and inhibit the adsorption of H2 on the catalytic surface, and benefit the formation of formate species as well. Although the amounts of CO adsorption on Cu1 Mg1 Ce9 Odelta and Cu1 Ba1 Ce9 Odelta catalysts were much more than other catalysts at lower temperatures, they were mainly desorbed in the reversible form, which had no contribution to the selective CO oxidation.

[DRIFTS study of Cu1Zr1Ce9Odelta catalysts for selective CO oxidation].

The Cu1Zr1Ce9Odelta catalysts synthesized with coprecipitation method were used into the selective CO oxidation in hydrogen-rich gas. The adsorbed species and the intermediates on Cu1Zr1Ce9Odelta catalysts were examined by in-situ diffuse reflectance FTIR spectroscopy (in-situ DRIFTS) technique. It was found that hydrogen, oxygen and CO in the feed stream were adsorbed competitively at the same adsorption sites on the surface of Cu1Zr1Ce9Odelta catalysts. The pretreatment with hydrogen caused the deep reduction of Cu+ species to Cu0 species and decreased the capacity of CO adsorption on the catalyst surface. The Cu1Zr1Ce9Odelta catalyst pretreated with oxygen offered more active oxygen species and inhibited the deep reduction of Cu+ species. The helium pretreatment only purified the surface of Cu1Zr1Ce9Odelta catalyst. Two IR bands at 2938.7 and 2843.8 cm(-1) due to bridged formate and bidentate formate species appeared at 180 degrees C. The active oxygen anion of Cu1Zr1Ce9Odelta catalyst could react with CO and produce carbonate species at room temperatures. The carbonate and formate species occupied the adsorption sites and deteriorated the catalytic performance of Cu1Zr1Ce9Odelta. Flushing the Cu1ZnrCe9Odelta catalyst with helium at 300 degrees C, the bidentate formate species on the catalyst surface decomposed to monodentate carbonate species and then further decomposed to CO2, which could release the adsorption sites and restore well the catalytic activity.

High activity of NiCo2O4 promoted Pt on three-dimensional graphene-like carbon for glycerol electrooxidation in an alkaline medium.

Spinel oxide NiCo2O4 supported on a three-dimensional hierarchically porous graphene-like carbon (3D HPG) material has been firstly used to enhance the activity of Pt for glycerol electrooxidation. The addition of NiCo2O4 into the Pt/HPG catalyst can significantly improve the catalytic performance for glycerol oxidation. When NiCo2O4 is added to the Pt/HPG catalyst, the onset potential is 25 mV more negative than that on the Pt/HPG catalyst without NiCo2O4. The current density at -0.3 V on the Pt-NiCo2O4 (wt 10 : 1)/HPG electrode is 1.3 times higher than that on the Pt (30 wt%)/HPG electrode. The Pt-NiCo2O4 electrode presented in this work shows great potential as an electrocatalyst for glycerol electrooxidation in an alkaline medium.

Decolorization of molasses fermentation wastewater by SnO(2)-catalyzed ozonation.

In the presence of O(3), the oxidative decolorization reaction on molasses fermentation wastewater with SnO(2) as a catalyst was studied. The results showed that SnO(2) accelerated the ozone oxidation reaction and the oxidative decolorization of molasses fermentation wastewater was accelerated. Influences on SnO(2) catalytic ozonation activity by precipitants and the calcination temperature were studied by XRD, IR and TG-DSC. SnO(2) prepared by ammonia as the precipitant had higher catalytic activity and a stronger dehydroxylation. The IR spectra of adsorbed pyridine showed that there were Lewis acid sites on the surface of this SnO(2) catalyst. The main factors influencing molasses fermentation wastewater oxidative decolorization were the wastewater concentration, the O(3) concentration, the pH value and the catalyst dosage. The decolorization of wastewater was improved with the increase of the wastewater dilution ratio, the ozone concentration and the catalyst dosage. High activity *OH was found to be existing with less amount and low concentration in the process of SnO(2) catalyzed ozonation decolorization.

[XRD and FTIR spectra characteristics of nacreous layer in perna viridis].

The XRD and FTIR of aragonites in nacreous and prismatic layer of perna viridis were systematically measured, and the frequency variations of v1, v2 and v4 band of aragonites were especially analyzed. The results showed that both of them were aragonite and the frequency of v2 band differed in them, but the frequencies of other two bands were not altered and had the same values with cavernous aragonite. In the same specie of shell, the frequency of v2 band in nacreous layers was greater than that in prismatic layers, and there was a frequency shift of v2 band between them. For the first time, the phase transformation of biogenic aragonite was detected. After nacreous aragonite was heated at 300 degrees C, the frequency shift of v2 band was found. So it is concluded that the biogenic aragonite is related to the thermal effects in crystallizing process, meanwhile it stores excess energy. All of these can provide experiential basis for studying biomineralization theory.

[Preparation of premonitory Li(x)MoS2 and its spectral analysis].

Under the effect of ultrasonic waves, premonitory Li(x)MoS2 was prepared by n-butyl lithium intercalating in the MoS2 layers, using the single-molecular-layer exfoliated-restacked technology. The value of x was in the range from 0.93 to 0.96 determined by atomic absorption spectrometry. Micro-structure and essential regularity of Li(x)MoS2 were disclosed, for example octahedral configuration of Li(x)MoS2 was metastable. It could provide experimental data for synthesizing new hydrogenation catalysts for interaction of MoS2 with high activity and selectivity. This work will lay the foundation for the research on hydrogenation catalysts and the production of high value-added MoS2.

[Purification of sulfolene and its UV-Vis and FTIR spectral analysis].

Purification of raw sulfolene was investigated by adsorption method using activated carbon and exchange resin, and the sulfolene was detected by UV-Vis, FTIR and XRD. FTIR spectra of sulfolene and sulfolane were especially analyzed. The results showed that it was the best way to purify industrial grade sulfolene by activated carbon connected exchange resin. The sulfolane with high quality was synthesized by purified sulfolene through catalytic hydrogenation with catalyst. The conversion efficiency was more than 99.8%. It could provide experimental data for the technical reform of industry equipment.

[Preparation of Mo-Fe catalysts by sol-gel method and its XRD, FTIR spectral analysis].

The effect of catalyst atomic ratio on the performance of selective oxidation of p-xylene as a probe reaction over Mo-Fe catalysts prepared by sol-gel method was investigated. The catalyst evaluation results show that the optimum catalyst atomic ratio is n(Mo) : n(Fe) : n(Co) = 2.4 : 1 : 0.02 with a high catalytic activity. The composition of the catalyst is Fe2 (MoO4)3 and a little MoO3 having a cooperative effects during the oxidation of p-xylene, which was detected by XRD and FTIR. This study could provide experimental data for the technical reform of industry equipment.

[UV-Vis, FTIR and XRD spectroscopic analysis for the preparation of Pt/CNTs electrocatalysts].

Carbon nanotubes (CNTs) supported platinum electrocatalyst Pt/CNTs with high dispersion were prepared by a modified ethylene glycol method with sodium dodecyl sulfate (SDS) as the stabilizer. UV-Vis, FTIR and XRD spectroscopic analysis methods were used to study the preparation of the electrocatalysts, and the effect of the SDS addition to the ethylene glycol solution on the structure as well as the electrocatalytic activity of the Pt/CNTs electrocatalysts were also investigated. The results showed that PtCl6(2-) could form a complex compound with SDS, and all PtCl6(2-) were completely reduced by ethylene glycol; oxygen containing groups were produced on the surface of CNTs to facilitate the Pt nanoparticle absorption, and no SDS remained on the electrocatalysts; the Pt/CNTs electrocatalysts exhibited face-centered cubic structure; the particle size of Pt/CNTs-2 catalyst prepared by SDS addition was about 4. 5 nm. The CV test results showed that the Pt/CNTs-2 catalyst showed higher methanol electro-oxidation activity compared with Pt/CNTs-1 prepared by traditional ethylene glycol reduction method.

Transcriptome analysis revealed pivotal transporters involved in the reduction of cadmium accumulation in pak choi (Brassica chinensis L.) by exogenous hydrogen-rich water.

Hydrogen-rich water (HRW) has been widely used in research on plant resistance to Cd. However, the underlying molecular mechanism of HRW in ameliorating cadmium stress in vegetables is largely unknown. In this study, the RNA-sequencing analyses were used to characterize the role of HRW in the alleviation of Cd toxicity in Chinese cabbage seedlings. Based on the obtained results, two genes encoding metal ionic transporters, BcIRT1 and BcZIP2 were ultimately selected out. Then, a systematic validation of the metal ion transport function of these two ZIP-encoding genes of pak choi were performed via a yeast transformation system. The results showed that BcIRT1 and BcZIP2 increased the sensitivity of different yeast mutant strains to relative metal ionic stresses and facilitated the accumulation of metal ions (Cd2+, Mn2+, Zn2+, and Fe2+) in yeast; thus, it suggests that BcIRT1 and BcZIP2 probably have the ability to transport Cd2+, Mn2+, Zn2+ and Fe2+ in pak choi. The time-course and concentration-dependent expression profiles of BcIRT1 and BcZIP2 showed that as time with HRW increased, the effectiveness of the repression on the expression of BcIRT1 and BcZIP2 increased, and as the seedlings were exposed to increased Cd concentrations, the inhibition of BcIRT1 and BcZIP2 by HRW was also increased. Over all, these findings provide new insights into the genome-wide transcriptome profiles in pak choi and show that HRW reduced Cd uptake probably through inhibiting the expression of transporters related to Cd absorption, BcIRT1 and BcZIP2.

[Infrared study on adsorption of O3 at SnO2 surface].

SnO2 was prepared by precipitation method and mental oxides modified SnO2 catalysts were prepared by coprecipitation method. High concentration molasses fermentation wastewater degradation by SnO2 catalyzed ozonation was used as a probe reaction and IR spectra were used to study the adsorption of O3 at SnO2 and different metal oxides modification SnO2 surface. The results showed, that in the infrared absorption spectra of adsorption of O3 prepared by pure O2 at SnO2 catalyst surface, two obvious bidentate absorption double peaks were found at 1 027 and 1 055 cm(-1), and 2 099 and 2 122 cm(-1), respectively. However, there was competitive adsorption between O3 prepared by air, and CO and CO2. Then the O3 adsorption decreased, leading to the decrease in the degradation of molasses fermentation wastewater by SnO2 catalytic ozonation, and after 60 min reaction, the degradation rate by pure oxygen as oxygen source was 79.2%. It was 33.1% more by air as oxygen source. Similar strength adsorption peaks in the infrared spectra were found at 2 236, 2213 cm(-1) and 1 628, 1 599 cm (-1) with Fe2O3, NiO, CuO, ZnO, MgO, SrO and BaO modified SnO2. But the adsorption of CO2 and CO was different on modifier-SnO2, There was a wide absorption peak at 1 580-1 070 cm(-1) in the infrared spectra of transition metal modified SnO2, and two new peaks at 1 298 and 1 274 cm(-1) were found between 1 580 and 1 070 cm(-1) in the infrared spectra of alkaline-earth metals modified SnO2 catalysts. These changes leaded to a different catalytic ozonation activity of modifier-SnO2, the results of molasses fermentation wastewater degradation by ozone combined with alkaline-earth metal modified SnO2 was obviously better than ozone combined with transition metal modified SnO2. And among them, the ozonation catalytic activity of BaO-SnO2 was the best.

[Measurement and analysis of nanometer particles of silica and carbon black by diffuse reflection FTIR spectra].

By using FTIR-FTS3000 spectrometer and infrared diffuse reflection accessory, the spectra of the nanometer particles of silica, carbon black and their blends with different weight ratio were collected and characterized. It was found from the measured results that blue-shift and broadening phenomenon occurred in the nanometer particle materials in comparison with the mass ones. These phenomena could be explained by the little size effect and quantum size effect. No perfect spectrum could be collected because of the strong absorbance of the nanometer particle materials. For the blends of silica and carbon black there was a maximum absorption corresponding to the critical concentration, where the weight ratio of silica to carbon black was 100 : 20, and below this ratio the relationship between the function F(R) and the concentration obeyed Lambert-Beer's law. Above this ratio, the absorbance will not increase with increasing the proportion of the carbon black in the system.

Low molecular weight heparin in treating patients with lung cancer received chemotherapy: A meta-analysis.

OBJECTIVE: To systematically review the efficacy and safety of low molecular weight heparin (LMWH) in treating patients with lung cancer received chemotherapy. MATERIALS AND METHODS: Databases including PubMed, The Cochrane Library, Excerpt Medica Database, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, VIP, and Wanfang Data were searched for the randomized controlled trials (RCTs) about LMWH in treating patients with lung cancer received chemotherapy from the establishment to May 31, 2015. According to the inclusion and exclusion criteria, two reviewers independently screened literature, extracted data, and assessed quality of the included studies. Meta-analysis was then performed by using Review Manager 5.3 (Cochrane Collaboration, Oxford, UK) software. RESULTS: A total of eight RCTs involving 952 patients were finally included. Meta-analysis showed that compared with the control group, LMWH significantly improved the 1- and 2-year overall survival (OS) rates of the patients with lung cancer received chemotherapy (risk ratio [RR] =1.65, 95% confidence interval [95% CI] [1.20-2.26], P = 0.002; RR = 2.63, 95% CI [1.40-4.94], P = 0.003, respectively), and significantly reduced the incidence of venous thromboembolism (VTE) (RR = 0.40, 95% CI [0.23-0.69], P = 0.001), not significantly increased the incidence of major bleeding events and thrombocytopenia (RR = 1.29, 95% CI [0.57-2.96], P = 0.54; RR = 0.86, 95% CI [0.69-1.07], P = 0.18, respectively), and not significantly improved the overall response rate (RR = 1.24, 95% CI [0.98-1.57], P = 0.07). CONCLUSION: LMWH improves the 1- and 2-year OS rates of the patients with lung cancer received chemotherapy and reduces the incidence of VTE, not increase the incidence of major bleeding events and thrombocytopenia. These show that there is a certain effect of LMWH, and the security is good.