Assuntos
Lipodistrofia/induzido quimicamente , Fígado/diagnóstico por imagem , Nivolumabe/efeitos adversos , Hepatopatia Gordurosa não Alcoólica/induzido quimicamente , Antineoplásicos Imunológicos/efeitos adversos , Biópsia , Feminino , Humanos , Lipodistrofia/diagnóstico , Lipodistrofia/imunologia , Melanoma/tratamento farmacológico , Pessoa de Meia-Idade , Nivolumabe/uso terapêutico , Hepatopatia Gordurosa não Alcoólica/diagnóstico , Hepatopatia Gordurosa não Alcoólica/imunologia , Neoplasias Cutâneas/tratamento farmacológicoRESUMO
INTRODUCTION: Non-invasive, nanosecond, stepwise two-photon laser excitation of skin tissue was shown to induce melanin fluorescence spectra that allow for the differentiation of melanocytic nevi from cutaneous melanoma. METHODS AND ANALYSIS: This prospective, non-controlled, multicentre clinical study is performed to evaluate the diagnostic performance of the stepwise two-photon excited melanin fluorescence in the detection of cutaneous melanoma. The comparator will be the histopathological diagnosis. A total of 620 pigmented skin lesions suspicious for melanoma and intended for excision will be enrolled. ETHICS AND DISSEMINATION: Ethics approval was provided by the local ethics committees of the medical faculties of the University of Tuebingen, Heidelberg and Berlin. STUDY REGISTRATION: The FLIMMA study NCT02425475.