1.
Bioorg Med Chem Lett
; 21(23): 6950-4, 2011 Dec 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22033460
RESUMO
A series of CCR5 antagonists were optimized for potent inhibition of R5 HIV-1 replication in peripheral blood mononuclear cells. Compounds that met acceptable ADME criteria, selectivity, human plasma protein binding, potency shift in the presence of α-glycoprotein were evaluated in rat and dog pharmacokinetics.