Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 80
Filtrar
Mais filtros

Base de dados
País/Região como assunto
Tipo de documento
País de afiliação
Intervalo de ano de publicação
1.
Zentralbl Chir ; 141(1): 45-52, 2016 Feb.
Artigo em Alemão | MEDLINE | ID: mdl-24338802

RESUMO

BACKGROUND: Since January 2005, the situation of metabolic and obesity surgery in Germany has been constantly evaluated by the German Bariatric Surgery Registry (GBSR). Data registration is performed using an internet online database with prospective data collection. All registered data were analysed in cooperation with the Institute of Quality Assurance at the Otto-von-Guericke University Magdeburg. METHODS: Data collection includes primary and revision/redo-procedures. A main focus of the current study is the analysis of data regarding the perioperative management, in particular, administration of antibiotics. RESULTS: Since 2005 a significant increase of primary bariatric procedures has been reported. For evaluation of the antibiotic regimen 12 296 primary operations including 684 balloons (BIB), 2950 gastric bandings (GB), 5115 Roux-en-Y-gastric bypasses (RYGBP), 120 Scopinaro's biliopancreatic diversions (BPD), 164 duodenal switches (DS), 3125 sleeve gastrectomies (SG) and 138 other procedures were analysed. In total 77.3 % of the patients with primary procedures received perioperative antibiotics. Patients without concomitant comorbidities received antibiotics significantly less often compared to those with comorbidities. Wound infection rates were comparable for patients who underwent either gastric banding or sleeve gastrectomy. CONCLUSION: Surgery has been accepted step by step as a treatment for morbid obesity and its comorbidities in Germany during the last few years. There is only little experience in the literature regarding antibiotic therapy as well as prophylaxis in bariatric surgery. Based on the results of the current study we recommend rather the selective than the routine use of antibiotics depending on different parameters, e.g., operative time, preoperative BMI and concomitant comorbidities.


Assuntos
Antibioticoprofilaxia/métodos , Antibioticoprofilaxia/normas , Cirurgia Bariátrica/métodos , Cirurgia Bariátrica/normas , Garantia da Qualidade dos Cuidados de Saúde/normas , Adulto , Índice de Massa Corporal , Comorbidade , Feminino , Alemanha , Humanos , Masculino , Pessoa de Meia-Idade
2.
Zentralbl Chir ; 140(4): 407-16, 2015 Aug.
Artigo em Alemão | MEDLINE | ID: mdl-23824622

RESUMO

The increasing prevalence of morbid obesity in Germany is associated with an increasing number of metabolic surgical interventions. Short-term surgical and long-term metabolic complications such as nutrient deficiencies can be considered the main risks of metabolic surgery and its restrictive and malabsorbant surgical procedures. The aim of this compact short overview based on a selective literature search and our own clinical experience is to characterise the long-term metabolic complications, which are specific for the various bariatric procedures, and to refine the published guidelines for supplementation. Restrictive bariatric procedures can be associated with well-known surgical problems such as pouch dilatation or band migration, e.g., after gastric banding. After sleeve gastrectomy, emerging reflux disease can become a substantial problem. The most frequent deficiencies after restrictive procedures are related to B-vitamins whereas iron, folate, vitamin B1 and B12 and vitamin D deficiencies are associated with the malabsorptive procedure such as biliopancreatic diversion, duodenal switch and Roux-en-Y gastric bypass. Due to possible metabolic and surgical complications after bariatric surgery, patients need to undergo life-long medical follow-up investigations. The currently available guidelines of German Society of Treatment of Obesity (CAADIP) of DGAV for supplementation should be known and followed, in particular, by the physicians who i) are exceptionally involved in medical care of obese people and ii) do it in full awareness of the obligatory postoperative clinical observation.


Assuntos
Cirurgia Bariátrica/efeitos adversos , Deficiências Nutricionais/diagnóstico , Deficiências Nutricionais/terapia , Avaliação Nutricional , Complicações Pós-Operatórias/diagnóstico , Complicações Pós-Operatórias/terapia , Adolescente , Feminino , Seguimentos , Alemanha , Humanos , Síndromes de Malabsorção/diagnóstico , Síndromes de Malabsorção/terapia , Masculino , Necessidades Nutricionais
3.
Zentralbl Chir ; 140(3): 285-93, 2015 Jun.
Artigo em Alemão | MEDLINE | ID: mdl-25906018

RESUMO

BACKGROUND: The current situation in obesity and metabolic surgery since January 2005 has been investigated with the help of the quality assurance study on surgical therapy for obesity = German Bariatric Surgery Registry (GBSR). The data were acquired and analysed in cooperation with the Institute for Quality Assurance in Surgical Medicine at the Otto-von-Guericke University. METHODS: Data acquisition was done with the help of an online database. On a voluntary basis, all obesity and metabolic surgical interventions since 2005 have been recorded. In addition to the surgical data, the findings of the yearly follow-up investigations were recorded. RESULTS: Since 2005 there have been 1,263 gastric balloon procedures, 11,840 sleeve gastrectomies, 13,722 Roux-en-Y gastric bypasses and 3999 gastric banding operations. The average age of the male patients in all interventions was significantly higher. The average BMI of female patients who received a gastric banding or a gastric balloon procedure was significantly lower than that of the male patients. Men exhibited a higher incidence of comorbidities than women. CONCLUSION: The number of obesity and metabolic surgical interventions in Germany is continuously increasing. The results of the study on surgical therapy for obesity (GBSR) reveal significant differences in the gender-specific incidence of preoperative comorbidities. postoperative complications and mortality. Further studies on gender-specific aspects are necessary in order to optimise patient selection and reduce the incidence of postoperative complications.


Assuntos
Cirurgia Bariátrica/estatística & dados numéricos , Obesidade/epidemiologia , Sistema de Registros/estatística & dados numéricos , Caracteres Sexuais , Índice de Massa Corporal , Comorbidade , Estudos Transversais , Alemanha , Humanos , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Garantia da Qualidade dos Cuidados de Saúde , Fatores de Risco
4.
Int J Obes (Lond) ; 38(3): 334-40, 2014 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-24048144

RESUMO

OBJECTIVE: To examine the safety and effectiveness of adolescent bariatric surgery and to improve treatment recommendations for this age group. DESIGN: Prospective longitudinal registry. Since January 2005, patients undergoing bariatric surgery in Germany are enlisted in an online registry called 'study for quality assurance in obesity surgeries'. SUBJECTS: Adolescents and young adults up to the age of 21 years, operated from January 2005 to December 2010. MEASUREMENTS: Weight, BMI, comorbidities, complication rates. RESULTS: N=345 primary procedures were recorded by 58 hospitals. N=51 patients were under the age of 18 years. Follow-up information was available for 48% (n=167) of patients, with an average observation period of 544±412 days (median: 388 days). The most common surgical techniques were gastric banding (n=118, 34.2%), gastric bypass (n=116, 33.6%) and sleeve gastrectomy (n=78, 22.6%). Short-term complications (intra-operative; general postoperative; specific postoperative) were slightly lower for gastric banding (0.8%; 2.5%; 0.8%) than for gastric bypass (2.6%; 5.2%; 1.7%) or sleeve gastrectomy (0%; 9.0%; 7.7%). In accordance with published findings, weight and BMI reduction were lower for gastric banding (-28 kg; -9.5 kg m(-2)) compared to gastric bypass (-50 kg; -16.4 kg m(-2)) P< 0.001 or sleeve gastrectomy (-46 kg; -15.4 kg m(-2)) P< 0.001. Outcomes did not differ between the <18 and ≥18-year-old patients. CONCLUSION: Like in adults, bariatric surgery has low short-term complication rates and results in sustained weight loss in adolescents. However, the missing long-term observations prohibit a final conclusion about lasting effectiveness and safety. Clinical trials with structured follow-up programs and mechanisms to ascertain patient adherences are needed.


Assuntos
Gastrectomia , Derivação Gástrica , Obesidade Mórbida/cirurgia , Redução de Peso , Adolescente , Comorbidade , Feminino , Seguimentos , Gastrectomia/efeitos adversos , Derivação Gástrica/efeitos adversos , Alemanha/epidemiologia , Humanos , Masculino , Obesidade Mórbida/sangue , Obesidade Mórbida/epidemiologia , Avaliação de Resultados em Cuidados de Saúde , Seleção de Pacientes , Estudos Prospectivos , Sistema de Registros , Indução de Remissão/métodos , Medição de Risco , Índice de Gravidade de Doença , Resultado do Tratamento , Adulto Jovem
5.
Zentralbl Chir ; 138(4): 456-62, 2013 Aug.
Artigo em Alemão | MEDLINE | ID: mdl-23950081

RESUMO

In the international comparison and in Europe, the Federal Republic of Germany belongs to the countries with a very high prevalence of obesity (men, 67.1 %; women, 53 %). Among the European countries, the incidence of diabetes mellitus type 2 is also high ("Study of the health of adults in Germany" [DEGS]) - Robert Koch Institute). Not only for surgeons, this can be considered as a great challenge even in usual abdominosurgical interventions. 1. Surgical equipment needs to be adapted to the requirements for obese patients. 2. Minimally invasive surgery reduces not only complication rates with regard to postsurgical wound infection and hernia in such patients, it allows a competent assessment of the peritoneal cavity. 3. A great number of surgical tools and instruments can be used in normal weight as well as morbidly obese patients with no limitations - for conventional (open) surgical interventions, retractor systems should be available. 4. With regard to emergency surgery in patients who had formerly undergone bariatric surgery, a competent basic knowledge on the usual bariatric surgical interventions and the subsequent anatomic consequences as well as the more frequent mid- and long-term complications is necessary, which need to be partially approached with the surgical intervention. 5. For numerous oncosurgical interventions, no differences in postoperative outcome were found between normal weight and morbidly obese patients.


Assuntos
Abdome/cirurgia , Obesidade Mórbida/complicações , Obesidade Mórbida/cirurgia , Abdome Agudo/cirurgia , Cirurgia Bariátrica , Comparação Transcultural , Emergências , Feminino , Alemanha , Hérnia Abdominal/etiologia , Hérnia Abdominal/cirurgia , Humanos , Masculino , Procedimentos Cirúrgicos Minimamente Invasivos , Obesidade Mórbida/epidemiologia , Posicionamento do Paciente/métodos , Cuidados Pós-Operatórios/métodos , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/prevenção & controle , Cuidados Pré-Operatórios/métodos , Reoperação , Equipamentos Cirúrgicos , Instrumentos Cirúrgicos , Deiscência da Ferida Operatória/etiologia , Deiscência da Ferida Operatória/cirurgia , Resultado do Tratamento
6.
Zentralbl Chir ; 138(2): 180-8, 2013 Apr.
Artigo em Alemão | MEDLINE | ID: mdl-22753146

RESUMO

BACKGROUND: Since January 1st 2005, the situation of bariatric surgery has been examined in Germany. All data are registered prospectively in cooperation with the Institute of Quality Assurance in Surgery at the Otto-von-Guericke University of Magdeburg. METHODS: The voluntary data registration occurs in an internet online data bank. All primary bariatric procedures as well as re- and redo-procedures are documented. Follow-up data were collected once a year. Participation in the quality assurance study is obligatory for certificated centres. RESULTS: Since 2005 13,879 bariatric procedures have been performed at 83 hospitals. The number of primary procedures has increased from 596 in 2005 to 11,835 in 2010. Revisional surgery has been performed in 1,438 patients since 2005. Sleeve gastrectomy (SG) is the major procedure with 1,564 operations in 2010. The mean BMI was 48.8 kg/m². The incidence of comorbidities was 84.8%. CONCLUSION: Bariatric surgery has become more accepted in Germany. Beside the Roux-en-Y gastric bypass, sleeve gastrectomy is the most frequently performed operation. BMI and incidence of comorbidities are still high in comparison with literature values. Due to the lack of evidence, more randomised studies are necessary to standardise operative techniques and evaluate patient selection criteria. Quality assurance studies support a detailed analysis of these parameters.


Assuntos
Cirurgia Bariátrica/normas , Coleta de Dados/normas , Garantia da Qualidade dos Cuidados de Saúde/normas , Adolescente , Adulto , Idoso , Cirurgia Bariátrica/tendências , Índice de Massa Corporal , Criança , Comorbidade , Coleta de Dados/tendências , Feminino , Derivação Gástrica/normas , Derivação Gástrica/tendências , Gastroplastia/normas , Gastroplastia/tendências , Alemanha , Indicadores Básicos de Saúde , Humanos , Masculino , Pessoa de Meia-Idade , Avaliação de Processos e Resultados em Cuidados de Saúde/normas , Avaliação de Processos e Resultados em Cuidados de Saúde/tendências , Seleção de Pacientes , Garantia da Qualidade dos Cuidados de Saúde/tendências , Ensaios Clínicos Controlados Aleatórios como Assunto , Adulto Jovem
7.
Obes Surg ; 19(1): 105-12, 2009 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-18941846

RESUMO

BACKGROUND: Most studies on bariatric surgery outcomes are performed as clinical trials or reflect the clinical experience in single centers. The status of bariatric surgery in Germany has been examined since January 1st, 2005 with the cooperation of clinics and hospitals at the Institute of Quality Assurance in Surgery at the Otto-von-Guericke University of Magdeburg (Germany). METHODS: In this prospective multicenter observational study, the data obtained for all primary bariatric procedures, including all repeated operations, performed on consecutive patients with morbid obesity at participating hospitals from 2005 to 2007 were prospectively collected using an Internet online data registry. In particular, perioperative characteristics, such as the spectrum of diagnostic measurements, type of surgical procedures, and short- and long-term outcomes, were investigated. RESULTS: During the study period, 629 surgical procedures were performed at 21 hospitals in 2005, 828 procedures at 32 hospitals in 2006, and 1,666 procedures at 35 hospitals in 2007. In 2005 and 2006, gastric banding was the most frequently performed operation, followed by the Roux-en-Y gastric bypass (RYGBP). In 2007, a RYGBP was carried out in 42.1% of all bariatric procedures. Among all patients, 74.4% were female. The mean body mass index (BMI) was 48.5 kg/m(2) in 2005, 48.4 kg/m(2) in 2006, and 48.0 kg/m(2) in 2007. Follow-up data after 12 months were available for 63.8% of the patients in 2005 and 2006; these data showed greater reduction of BMI after malabsorptive rather than restrictive bariatric procedures. The mortality was 0.1% (30 days) and 0.16% (overall). CONCLUSION: As indicated by the worldwide trend, there is an ongoing change from restrictive bariatric procedures to malabsorptive procedures and sleeve gastrectomy. Although the BMIs of German patients undergoing bariatric surgery appear to be substantially higher than those of patients from most other countries, there were no differences in intraoperative and short-term complications or in overall outcomes during follow-up when compared with published studies.


Assuntos
Cirurgia Bariátrica/estatística & dados numéricos , Obesidade/cirurgia , Adulto , Cirurgia Bariátrica/efeitos adversos , Cirurgia Bariátrica/mortalidade , Estudos de Coortes , Feminino , Alemanha , Pesquisas sobre Atenção à Saúde , Humanos , Masculino , Pessoa de Meia-Idade , Obesidade/complicações , Obesidade/mortalidade , Garantia da Qualidade dos Cuidados de Saúde , Reoperação , Resultado do Tratamento , Redução de Peso
8.
Zentralbl Chir ; 134(6): 573-5, 2009 Dec.
Artigo em Alemão | MEDLINE | ID: mdl-19492284

RESUMO

CASE REPORT: In a 60-year-old patient with an inflammatory pseudotumour due to a penetrating gastric ulcer, extended gastrectomy and partial diaphragm resection were carried out 7 years ago. The diaphragmatic defect was closed with a prosthetic patch (polytetrafluoroethylene, PTFE). The patient currently complains about cough during eating, fever and weight loss. By means of fluoroscopy after barium swallow, an enterobronchial fistula was detected. Intraoperatively, a 10-cm long, dead-end piece jejunum was found after end-to-side oesophagojejunostomy. The torn-out PTFE patch was seen in a subphrenic empyemic cavity, which communicated with the dead-end length of jejunum and the peripheral bronchi of the lower lobe via a fistula. After resection of the dead-end length of jejunum and extensive debridement of the residual parts of the diaphragm as well as oversewing of the bronchial fistula, the diaphragmatic defect was covered with a distally pedicled flap of the latissimus dorsi muscle. There were no postoperative complications. CONCLUSION: In case of potential infections the implantation of alloplastic material must be excluded. The reversed latissimus dorsi muscle flap proved to be ideal autologous material for reconstruction of the hemidiaphragm. The dead-end length of jejunum in the end-to-side oesophagojejunostomy should be short to prevent any retention of food. Pulmonary resection is not absolutely necessary in the case of enterobronchial fistulation.


Assuntos
Fístula Brônquica/cirurgia , Diafragma/cirurgia , Gastrectomia , Granuloma de Células Plasmáticas/cirurgia , Fístula Intestinal/cirurgia , Doenças do Jejuno/cirurgia , Úlcera Péptica Perfurada/cirurgia , Politetrafluoretileno , Complicações Pós-Operatórias/cirurgia , Próteses e Implantes , Anastomose em-Y de Roux , Fístula Brônquica/diagnóstico , Desbridamento/métodos , Esôfago/cirurgia , Seguimentos , Humanos , Fístula Intestinal/diagnóstico , Doenças do Jejuno/diagnóstico , Jejuno/cirurgia , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/diagnóstico , Reoperação , Retalhos Cirúrgicos
9.
Zentralbl Chir ; 134(6): 532-6, 2009 Dec.
Artigo em Alemão | MEDLINE | ID: mdl-20020385

RESUMO

Obesity in childhood and adolescents has gained epidemic proportions; in Germany 15-20 % of boys and girls are overweight, more than 6 % are known to be obese. By now, 25 % of relevant people show a pathological glucose intolerance, 4-5 % are developing type 2 diabetes mellitus (T2DM). In addition, metabolic disorders leading to hypertension and cardiac, renal or ophthalmological complications could be named as serious comorbidities. Medical and behavioural intervention as treatment for obesity in childhood remains largely ineffective: 5-10 % weight loss within 2 years rarely results in significant durable success. In adults, bariatric surgery is being used increasingly as an effective approach to achieve weight loss and to improve serious medical comorbidities, in particular T2DM. Enhancement of quality of life and explicit extension of survival are concomitant phenomenons. To date, a range of different types of bariatric procedures has been performed in adolescents, but studies evaluating and analysing preoperative data, postoperative course and follow-up in a representative number of patients younger than 18 years are still lacking. Nevertheless, current experience suggests significant weight loss and improving obesity-related medical comorbidities after bariatric surgery in adolescents too. Moreover, bariatric surgery in adolescents seems to induce less complications and a shorter hospital stay than in adults. Al-though surgical therapy for obesity in this group of patients remains an individual decision, even though explicit guidelines have been published specifying inclusion and exclusion criterias. Analysis of our own patient group and results of the study of the quality assurance "surgical treatment of morbid obesity" are appropriate tools to evaluate surgical techniques and to provide long-term follow-up.


Assuntos
Cirurgia Bariátrica/métodos , Adolescente , Adulto , Índice de Massa Corporal , Criança , Comorbidade , Comportamento Cooperativo , Gastroplastia/métodos , Humanos , Comunicação Interdisciplinar , Laparoscopia/métodos , Tempo de Internação , Obesidade/complicações , Avaliação de Processos e Resultados em Cuidados de Saúde , Equipe de Assistência ao Paciente , Cuidados Pós-Operatórios/métodos , Complicações Pós-Operatórias/etiologia , Guias de Prática Clínica como Assunto , Estudos Retrospectivos
11.
Br J Educ Psychol ; 78(Pt 4): 567-80, 2008 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-18590607

RESUMO

BACKGROUND: Primary-school teachers are expected to detect problems related to language function, but the teachers' evaluations may be heavily influenced by gender and classroom behaviour. AIM: To investigate the relationship between language problems (LPs) and behaviour-emotional problems as rated by primary-school teachers. METHODS: All participants participated in a population-based study, the Bergen Child Study (BCS). Teachers of 9,072 children and parents of 6,234 children completed forms containing questions pertaining to language function and the strengths and difficulties questionnaire (SDQ) to screen for behaviour-emotional problems. LP was defined as a score above the 95th percentile on the sum score of five language items. Children achieving a total SDQ score above the 90th percentile were defined as high scorers, indicating a high risk for behavioural-emotional problems. RESULTS: Based on teacher reports, 540 children were defined as having LP, more boys (N=366) than girls. Children defined as having LP were reported to have significantly higher scores on all SDQ subscales, and a higher total difficulty score than children without language problems (NLP). More LP boys than LP girls were defined as high scorers on the SDQ, with the highest effect size on the hyperactivity-inattention subscore. The agreement between teachers and parents was moderate to low, with the highest consensus of behaviour-emotional problems in children with LP. CONCLUSIONS: Primary-school children defined as having LP according to their teachers are frequently characterized by behavioural-emotional problems. Further assessment is warranted for primary-school children defined as having LP by their teachers.


Assuntos
Afeto , Transtornos do Comportamento Infantil/epidemiologia , Transtornos do Comportamento Infantil/psicologia , Transtornos da Linguagem/epidemiologia , Transtornos da Linguagem/psicologia , Comportamento Social , Criança , Docentes , Feminino , Humanos , Masculino , Pais , Relações Profissional-Família , Inquéritos e Questionários
14.
Obes Surg ; 16(3): 372-4, 2006 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-16545172

RESUMO

A morbidly obese woman (BMI 56 kg/m2) in 1998 underwent laparoscopic placement of an adjustable gastric band by the perigastric approach. 5 years later, she complained of reflux and weight regain. X-ray with contrast revealed pouch dilatation. She subsequently underwent a laparoscopic revision including retrocardia band replacement using the pars flaccida technique. During the further course, an epiphrenic diverticulum was diagnosed. Because of danger of perforation of the large thin-walled diverticulum and the esophageal motility disorder, the band was laparoscopically removed and the diverticulum was resected via a transhiatal approach. This case presents a very rare complication after placement of a gastric band and its successful management.


Assuntos
Divertículo Esofágico/etiologia , Gastroplastia/efeitos adversos , Obesidade Mórbida/cirurgia , Remoção de Dispositivo , Divertículo Esofágico/cirurgia , Feminino , Refluxo Gastroesofágico/etiologia , Humanos , Laparoscopia , Pessoa de Meia-Idade , Reoperação
15.
Eur J Surg Oncol ; 32(3): 297-302, 2006 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-16414235

RESUMO

AIMS: To assess the maximum tolerability of a combined therapy regimen of gemcitabine and docetaxel, and to evaluate tumour response rate, survival time and tolerability in patients receiving these agents for advanced pancreatic carcinoma. PATIENTS AND METHODS: Patients (n=68) with pancreatic carcinoma (advanced and/or unresectable tumour growth or histopathologically diagnosed metastases) were enrolled in a multicenter phase-I (n=25) and phase-II study (n=43). Treatment during phase II of the study was continued until either complete tumour remission (CR), tumour progression, indicated clinically or by means of radiological imaging, or until unacceptable toxicity occurred. RESULTS: Phase I: the tolerability maximum of the combined agents was established at gemcitabine 1000 mg/m(2) and docetaxel 35 mg/m(2) with tolerable adverse events. Phase II: a total of 139 chemotherapy cycles were completed (mean, 3.2; range, 1-10). While CR was achieved in three of 43 patients (7%), in five further cases, partial remission (PR) was documented, amounting to an overall response rate (OR) of 18.6%. Eighteen patients showed stable disease (41.9%), whereas in 17 of 43 subjects (39.5%), primary tumour progression was detected. The median survival time was 9.0 months; the 1-year survival rate was 13.9% (six of 43 patients). These results were associated with a side-effect profile of moderate severity and acceptable quality of life (QOL). CONCLUSION: The combination of gemcitabine and docetaxel for chemotherapy in unresectable pancreatic carcinoma was well tolerated. Survival time and 1-year survival rate proved promising and the regimen appears suitable for further evaluation in a prospective phase-III study setting.


Assuntos
Antimetabólitos Antineoplásicos/uso terapêutico , Antineoplásicos Fitogênicos/uso terapêutico , Carcinoma/tratamento farmacológico , Desoxicitidina/análogos & derivados , Neoplasias Pancreáticas/tratamento farmacológico , Taxoides/uso terapêutico , Adulto , Idoso , Carcinoma/mortalidade , Carcinoma/secundário , Desoxicitidina/uso terapêutico , Docetaxel , Quimioterapia Combinada , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Pancreáticas/mortalidade , Neoplasias Pancreáticas/patologia , Ribonucleotídeo Redutases/antagonistas & inibidores , Taxa de Sobrevida , Resultado do Tratamento , Gencitabina
16.
Eur J Surg Oncol ; 32(4): 420-5, 2006 May.
Artigo em Inglês | MEDLINE | ID: mdl-16520014

RESUMO

AIMS: Transrectal ultrasonography (TRUS) is the diagnostic tool of choice for local staging of rectal carcinoma. The accuracy in determining of tumour infiltration depth has been reported to reach 95% (on average, 85%). The aim of the study was to analyse the diagnostic accuracy of the TRUS in the clinical routine. PATIENTS AND METHODS: From 01/01/2000 to 12/31/2003, all patients with rectal carcinoma were enrolled in a prospective multicenter observational study. In case of complete findings of pre-operative TRUS and post-operative histological investigation of the surgical specimen on the tumour infiltration depth, overall accuracy of TRUS was determined. RESULTS: Overall, 13,610 patients with rectal carcinoma were enrolled in the study. Five thousand and fifty-six subjects (37%) underwent TRUS. In 3,501 patients, TRUS finding (uT-stage) could be compared with the result of the definitive histologic investigation (pT-stage). The accuracy of TRUS in all T-stages was 65.8%. The highest sensitivity was achieved in the T3-stage (74.9%), while in T2, T1, and T4, it was 59.6, 59.0 and 31.1%, respectively. In discriminating tumour growth limited to the rectal wall vs that through the rectal wall into the neighboring tissue, TRUS-associated accuracy was 76.5%. There were no differences between various tumour locations above the anocutaneous line. CONCLUSIONS: Diagnostic accuracy of TRUS in determining depth of tumour infiltration within or through the rectum wall in the routinuous diagnostic of rectal carcinoma does not reach the excellent published study results. A considerable improvement of the qualitative outcome in using this specific diagnostic tool appears to be recommendable to utilize its advantages such as high accuracy, efficacy, and practicability in the diagnostic process and deriving consequences for a possible neoadjuvant treatment as well as optimal planning of the surgical approach.


Assuntos
Carcinoma/diagnóstico por imagem , Carcinoma/patologia , Endossonografia , Medicina de Família e Comunidade , Estadiamento de Neoplasias/métodos , Neoplasias Retais/diagnóstico por imagem , Neoplasias Retais/patologia , Estudos de Viabilidade , Humanos , Estudos Prospectivos , Reprodutibilidade dos Testes
17.
Chirurg ; 77(3): 244-50, 2006 Mar.
Artigo em Alemão | MEDLINE | ID: mdl-16395575

RESUMO

BACKGROUND: Adjustable gastric banding is a popular bariatric operation in Europe. About 1500 patients per year undergo a such procedures in Germany. Clinical data on the rate of long-term complications such as pouch dilatation, slippage, and band migration are available in only a few long-term studies with small numbers of patients. Meta-analyses report on comordities and reduction in weight. The rate and management of long-term complications were examined at this inquiry. METHODS: Ninety hospitals were asked about rates of band implantation, follow-up, and complications. Thirty-eight hospitals (42.2%) participated in the study. The management of complications including slippage, pouch dilatation, and band migration was analyzed. RESULTS: At 35 hospitals, 4138 patients underwent gastric banding procedures in 25 hospitals over more than 5 years. The mean follow-up rate is presently 85.3%. Long-term complications were described in 8.6% of the patients. Pouch dilatation occurred in 5.0%, slippage in 2.6%, and band migration in 1.0%. CONCLUSIONS: Laparoscopic adjustable gastric banding can effectively achieve weight loss. However, band-related and functional complications influence late outcome. The rate of long-term complications was equivalent to that already in the literature.


Assuntos
Gastroplastia/instrumentação , Complicações Pós-Operatórias/epidemiologia , Índice de Massa Corporal , Estudos Transversais , Remoção de Dispositivo/estatística & dados numéricos , Falha de Equipamento/estatística & dados numéricos , Seguimentos , Migração de Corpo Estranho/epidemiologia , Migração de Corpo Estranho/etiologia , Migração de Corpo Estranho/cirurgia , Alemanha , Inquéritos Epidemiológicos , Humanos , Incidência , Laparoscopia/estatística & dados numéricos , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/cirurgia , Reoperação/estatística & dados numéricos
18.
Chirurg ; 87(9): 762-767, 2016 Sep.
Artigo em Alemão | MEDLINE | ID: mdl-27277557

RESUMO

Increasing prevalence of morbid obesity in Germany is associated with an increasing number of bariatric surgical interventions.Based on the effectiveness of bariatric surgery with regard to a significant reduction of body weight and comorbidity as well as improvement of the quality of life compared with conservative measures, its value and impact has been substantially increased. Long-term metabolic deficits such as nutrient deficiencies can be considered the main risks of various restrictive, combined and malabsorptive procedures of bariatric surgery.The aim of this overview is to characterize metabolic complications after bariatric surgery and their prophylaxis, which require a temporary or permanent surveillance and, if necessary, effective supplementation.Bariatric surgical interventions such as gastric banding (GB) and sleeve gastrectomy (SG) can be subsequently associated with deficiencies related to B­vitamins whereas iron, folate, and vitamins B1, B12 and D deficiencies might be consequences of malabsorptive procedures such as biliopancreatic diversion, duodenal switch and Roux-en-Y gastric bypass.Due to possible metabolic and surgical complications after bariatric surgery, patients need to undergo life-long follow-up investigations. The currently available guidelines of the American Association of Bariatric and Metabolic Surgery are the basis for the latest recommendations on supplementation and treatment in bariatric surgery.


Assuntos
Cirurgia Bariátrica/efeitos adversos , Suplementos Nutricionais , Desnutrição/terapia , Complicações Pós-Operatórias/terapia , Humanos , Fatores de Risco
19.
Obes Surg ; 26(11): 2562-2571, 2016 11.
Artigo em Inglês | MEDLINE | ID: mdl-27112588

RESUMO

BACKGROUND: Evidence-based data on optimal approach for prophylaxis of deep venous thrombosis (VTE) and pulmonary embolism (PE) in bariatric operations is discussed. Using antithrombotic prophylaxis, weight adjusted the risk of VTE and its complications have to be balanced with the increased bleeding risk. METHODS: Since 2005, the current situation for bariatric surgery has been examined by quality assurance study in Germany. As a prospective multicenter observational study, data on the type, regimen, and time course of VTE prophylaxis were documented. The incidences of clinically diagnosed VTE or PE were derived during the in-hospital course and follow up. RESULTS: Overall, 31,668 primary bariatric procedures were performed between January 2005 and December 2013. Most performed operations were 3999 gastric banding (GB); 13,722 Roux-en-Y-gastric bypass (RYGBP); and 11,840 sleeve gastrectomies (SG). Gender (p = 0.945), surgical procedure (p = 0.666), or administration of thromboembolic prophylaxis (p = 0.272) had no statistical impact on the DVT incidence. By contrast, BMI (p = 0.116) and the duration of thromboembolic prophylaxis (p = 0.127) did impact the frequency of onset of DVT. CONCLUSION: Age, BMI, male gender, and a previous history of VTE are the most important risk factors. The drug of choice for VTE is heparin. LMWH should be given preference over unfractionated heparins due to their improved pharmacological properties, i.e., better bioavailability and longer half-life as well as ease of use. Despite the low incidence of VTE and PE, there is a lack of evidence. Therefore, prospective randomized studies are necessary to determine the optimal VTE prophylaxis for bariatric surgical patients.


Assuntos
Cirurgia Bariátrica/efeitos adversos , Obesidade/cirurgia , Embolia Pulmonar/prevenção & controle , Trombose Venosa/prevenção & controle , Adulto , Cirurgia Bariátrica/métodos , Quimioprevenção , Comorbidade , Feminino , Alemanha , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Obesidade/epidemiologia , Estudos Prospectivos , Embolia Pulmonar/tratamento farmacológico , Embolia Pulmonar/etiologia , Garantia da Qualidade dos Cuidados de Saúde , Sistema de Registros , Fatores de Risco , Trombose Venosa/tratamento farmacológico , Trombose Venosa/etiologia
20.
Chirurg ; 76(7): 689-95, 2005 Jul.
Artigo em Alemão | MEDLINE | ID: mdl-15688180

RESUMO

BACKGROUND: Adjustable silicone gastric banding is an effective and safe treatment for morbid obesity. Migration of the band through the stomach wall is a long-term complication. The causes, clinical symptoms, timing, and incidence of band migration have not yet been investigated. METHODS: We report our experience over 9 years. Between February 1995 and February 2004, we performed adjustable silicone gastric banding in 161 patients, with follow-up of about 90.5% of cases. Mean follow-up time was 60.4 months. Cases of erosion were studied retrospectively. RESULTS: Eight patients (4.9%) developed band migration. In seven, the migration occurred between 30 and 86 months after band implantation. In one case, the migration occurred 10 months after laparoscopic repositioning of the band to avoid pouch dilatation. In all cases, the bands were removed. CONCLUSION: Band migration is a late complication after gastric banding that requires band removal. Various symptoms and complications of band migration influence the kind of band removal. The causes of band migration and its treatment are discussed.


Assuntos
Migração de Corpo Estranho , Gastroplastia/efeitos adversos , Obesidade Mórbida/cirurgia , Complicações Pós-Operatórias , Feminino , Seguimentos , Migração de Corpo Estranho/diagnóstico , Migração de Corpo Estranho/cirurgia , Gastroscopia , Humanos , Laparoscopia , Masculino , Reoperação , Estudos Retrospectivos , Silicones , Fatores de Tempo
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA