[Child tuberculosis at the teaching hospital of Brazzaville from 1995 to 2003]. / La tuberculose chez l'enfant au CHU de Brazzaville de 1995 à 2003.

In the paediatric service of the teaching hospital of Brazzaville, 582 files of children hospitalized were studied from January 1995 to December 2003. To determine tuberculosis frequency among sickle cell children and estimate the clinical and paraclinical aspects, a case-control study of tubercular patients with HIV negative serology was carried out by comparing at the same time a cohort of 75 sickle cell patients versus 125 patients without sickle cell disease. The results of these studies are as follows. The main assessment is the high frequency of tuberculosis. In 1995 the tuberculosis rate reaches 8%, in 2003 it was up to 13.6%, and 20.6% in 2000 due to the serious consequences of the recurrent wars between 1993 and 1999. Another cause of that high frequency is the rate of HIV/aids patients with a frequency of 2.5% of hospitalization ranging from 1.6 to 3.2%, among them 35% of the tubercular patients were seropositive. The tuberculosis prevalence was 7.4% among sickle cell patients versus 14.2% among control patients. Infection was more often identified in control patients (51.2%) than in sickle cell patients (24%). 68% of the parents were really poor and 18.5% of the children were evicted from their home by war. The pulmonary localizations were prevailing in groups of patients with sickle cell disease as well as in group of control patients. Pleuritis was observed in 8% of the patients with sickle cell disease versus 16.8% for control patients (P = 0.02). No patient with sickle cell disease had a miliary. Anergia to tuberculin test was reported in 35.8% sickle cell patients versus 10.4% for the control patients (P = 0.001). Tuberculosis prevalence is higher among control patients than in sickle cell patients. The high proportion of clinical and paraclinical data of tuberculosis did not significantly differ from the two groups. Evolution was good for 98% of the patients, 1.4% of them died; 74% of deceased patients were affected by HIV/aids.

[Hydrocholecystis, a rare etiology of painful abdominal crisis in sickle cell disease. About two cases]. / Hydrocholécyste, cause rare de crises douloureuses abdominales chez le drépanocytaire. A propos de deux cas.

The authors report two cases of hydocholecystis causing abdominal pains in the sickle cell child. The patients were two girls aged respectively 4 and 12. Hydrocholecystis is defined by acute distension of the gallbladder The diagnosis was made by scan which allowed to follow the evolution in the two sickle cell children. After two crises, no more recurrence was noted in the first patient, on the other hand in the second child recurrences became more frequent. Some authors indicate surgery systematically while others recommend it only after several recurrences.

[Tuberculosis and HIV/AIDS co-infection in children: experience carried out in paediatric service of the teaching hospital of Brazzaville, Republic of Congo (1995-2004)]. / Tuberculose et infection dues au VIH/sida chez l'enfant: expérience du service de pédiatrie du CHU de Brazzaville, Congo (1995-2004).

Epidemiologic, clinical and paraclinical data of 126 children with tuberculosis whose HIV status was known, have been compared. Among them, 65% were HIV positive, the co-infection tuberculosis HIV/AIDS was observed in all social categories. The source of contamination was discovered for 72% of the patients. The mother was involved in 47.5% of cases. The main reasons of consultation were a long standing fever a chronic cough and a weight loss. Diarrhea was mainly observed in positive HIV patients (p = 0.00). The general condition was influenced by a weight loss which was more important in positive patients with a IMC lower than 10 in 12.8% of cases. There was no significant difference between all clinical forms. Digital hippocratism, chronic otitis and parotiditis were only observed in positive HIV patients with skin illness ten times more frequent (p = 0.00). Anergia to tuberculin tests (78.4%) and a sedimentation speed up to 100 mm at the first hour were observed in more than 60% of the positive HIV patients (p = 0.001). Evolution was favorable under treatment for 84% of positive HIV patients with an increasing weight becoming weaker after one month of treatment. All deaths happened among that population.

[Recurrent quadric paralysis in an 11-year-old girl with spinal tuberculosis]. / Tétraplégie récidivante chez une enfant de 11 ans présentant un mal de Pott cervical.

The authors report a recurring quadric paralysis in a 11-year-old girl with cervical, pulmonary and mediastinal tuberculosis. The diagnosis was belated. After the first treatment with anti tuberculosis drugs and immobilization with a surgical collar, an improvement has been obtained; but at the 8th month of this treatment, a partial paralysis of superior members and total paralysis of inferior members appeared. A treatment with streptomycin, ethambutol, rifampicin, pyrazinamide, isoniazide, and prednisone was undertaken. The spontaneous motility was observed at 37 days of treatment. However, at the 8th months of this treatment, quadric paralysis happened again after a fall down. After immobilization with a new surgical collar and prednisone, the spontaneous motility came back again 3 months later.

[Schooling of the child and teenager suffering from sickle-cell disease in 2004, Brazzaville, Congo]. / Scolarité de l'enfant et de l'adolescent drépanocytaire en 2004 a Brazzaville, Congo.

A case-control transversal study has been carried out in March 2004 in the paediatric unit of the Brazzaville teaching Hospital to assess the impact of the sickle cell disease on school-age children. School-age children and teenagers of both sex were distributed in 228 homozygote sickle cell children (group I) aged of 5 years old and 8 months old to 21 and 245 children recruited in state schools aged of 5 years old and 6 months to 19 years old. In the group I, 78 children suffering from sickle cell disease are ahead in their school achievement, 59 have a normal education and 91 meet some difficulties with no significant difference; in the group II, 122 children are ahead in their school achievement, 81 have a normal education and 42 meet difficulties (p < 0,001). The average of children having school difficulties was 2,4 +/- 1,5 years in the group I with extremes ranging from 1 to 3 years. By comparing both groups in primary school, no difference was to be found in children doing well at school and children having a normal education: 54 children of the group II are reported being ahead in their school achievement (39, 7%) and 81 children in the group II (55, 1%); normal education for 38 children of the group 1 (28%) and 58 children in the group II (39, 5%). On the other hand, 44 children are having school difficulties in the group I (32, 3%) against 8 children in the group II (5, 4%) (p < 0,001). As a matter of form we have observed that ahead schooling is to be found in 24 sickle cell children at HbF < 10% (41, 4%) and 54 sickle cell children at HbF < 10% (34, 2%) (p < 0,05); normal education in 14 children with sickle cell disease at HbF > 10% (24, 1%) and 45 children with sickle cell disease at HbF < 10% (25, 9%) and school difficulties in 20 children with sickle cell disease at HbF > 10% (34, 5%) and 71 children with sickle cell disease at HbF < 10% (39, 9%).

[Sickle-cell crisis in the child and teenager in Brazzaville, Congo. A retrospective study of 587 cases]. / Les crises vaso-occlusives drépanocytaires chez l'enfant et l'adolescent a Brazzaville, Congo. Etude rétrospective de 587 cas.

Using files related to children admitted at the Brazzaville teaching hospital (Congo) between May 1995 and May 2002, the authors have studied the part of sickle cell crisis (SCC) in the sickle cell disease, have assessed the epidemiological particularities, the relation between some clinical, biological factors as well as the severity of the disease. On the whole, 587 SCC have been observed in homozygous SS children aged 6 to 17. The distribution was as follows: painful osteo-articular crisis (58.6%), abdominal crisis (23.5%), acute chest syndrome (14%), neurological strokes (3.2%) and priapism (0.7%). The neurological strokes (75%) and the hand-foot syndrome (77.8%) were predominant in male. As regards the interaction age-localization of the crisis, the hand-foot syndrome mainly concerned children under five, long bones and rachis impairment those aged 11 to 15; abdominal and neurological crisis were observed especially before the age of 10, the acute chest syndrome after 10 (68.3%). Malaria (48.9%) and bacterial or viral infections (24.5%) proved to be the triggering factors when these are identified (188 cases). SCC occurred in 67.5% of the cases during the hot and rainy seasons. Moreover the haemoglobin F rate above 10% was correlated with a low prevalence of SCC, in particular the potentially severe crisis, revealing at the same time its protective value. These results show that SCC, by their frequency and/or their severity constitute a major handicap when the vital prognosis is not involved. Rigorous health habits, appropriate vaccination programme, adequate malarial prophylaxis, optimal transfusional strategy and especially the use of hydroxyurea, prove to be urgent preventive measures to put into practice. Their efficient implementation will provide a better quality of life to the sickle cell patient and will decrease the risks of severe crisis.

[Radiological profile in 92 children suffering from Pott's disease]. / Aspects radiologiques du mal de Pott chez i'enfant. A propos de 92 cas.

The aim of this cross-sectional study was to analyse the radiological profile in 92 patients with Pott's disease and to identify severity factors. Among these subjects, aged from 11 months to 15 years old (average: 7.5 years), 37% of children had neurological signs; the HIV test was positive in 11 % of cases. Localisations were mainly dorsal (61%) and thoracic (49%). They were often associated. Almost all patients had lesions on one vertebra (31.5%) or 2 vertebrae (38%). Most of lesions were spondylitis (61%), paravertebra abscess (35%) and compressing vertebra (34%). The severity of vertebra localisations was correlated with late diagnosis and presence of neurological complication, while a high sedimentation rate didn't appear to be a factor of severity. Therefore radiology remains essential in Pott's disease evaluation providing precious information for the diagnosis and prognosis of spine tuberculosis.

[Effects of age on causes of hospitalization in children suffering from sickle cell disease]. / Causes d'hospitalisation des enfants drépanocytaires: influence de l'age (C.H.U. de Brazzaville, Congo).

The objective of this work was to assess the frequency the nature of complications and prognosis of the disease in children suffering from sickle cell disease. This retrospective study was conducted from January 2002 to December 2003 among 251 children suffering from sickle cell disease, hospitalized at the Brazzaville Teaching Hospital, Congo. The main hospitalization causes were dominated by the vaso-occlusive crisis (26.7%), anaemic crisis (20.3%) and infections (36.6%). The vaso-occlusive crisis were observed particularly in the 5 year-old children (p < 0.05); the hand-foot syndrome concerned in particular children under 5 years old. Anaemic crisis were found almost exclusively in patients under 5 (p < 0.05). The infections in children under 5 (35.8%) were almost as frequent as in older children (37.4%). Some non infectious complications were only observed in children above 5: cholithiasis, 4 cases; heart failure, 4 cases; hip osteonecrosis, 1 case. Global mortality was 4.8% and higher in children under five (p > 0.05). In addition, the death causes were dominated by anaemic crisis. In conclusion, this study stresses on the need to implement a primary prevention as well as a secondary prevention adapted to age.

[Body composition in Negro African children suffering from sickle cell disease. A mixed cross-sectional longitudinal study in Brazzaville, Congo]. / Composition corporelle d'enfants drépanocytaires homozygotes congolais. Etude longitudinale a Braz- zaville, Congo.

This study evaluates the changes of body composition in homozygous children suffering from sickle cell disease and appreciates the interaction between some factors of severity of the disease. A mixed cross-sectional longitudinal study with control cases cohort was conducted in Brazzaville (Congo) among 91 children with sickle cell disease (45 boys and 46 girls) and 95 healthy children (48 boys and 47 girls), aged of 8-17 years old. Each group was initially divided into three subgroups of age: 8, 11, 14. These children were subsequently followed for 3 years. Each year, at the same period, body mass, percentage of body fat, lean body mass and body mass index were evaluated in the two groups and then compared. The effects of frequency of painful episodes, the number of severe anaemia crisis and haemoglobin F on different variables were also appreciated. The children with sickle cell disease had stunting, lower values of body mass (p < 0.001), percentage of fat (p < 0.01), lean body mass (p < 0.01), and body mass index (p <0.001) between 8 and 17 years of age. In addition, we observed a non linear association between body mass index and fat percentage, but this interaction was stronger in girls. Finally the yearly frequency of painful episodes, the number of severe anaemia crisis and haemoglobin F had most of the time an influence on body composition. Children with sickle cell disease had a decreased body composition influenced by the complications associated with the disease . These limitations are modulated by haemoglobin F but the body composition is affected by painful episodes and severe anaemic crisis. Therefore more care and attention are recommended for the children suffering from sickle cell disease in order to control this severe disease.

Mother-to-child transmission of HIV-1 in Congo, central Africa. Congolese Research Group on Mother-to-Child Transmission of HIV.

OBJECTIVE: To assess the risk of mother-to-child transmission of HIV-1 in a central African population and to study maternal factors associated with perinatal transmission. DESIGN: Prospective cohort study of infants born to HIV-1-positive women and controls born to HIV-1-negative women enrolled sequentially in two prenatal clinics and one maternity hospital in Brazzaville, Congo. SUBJECTS AND METHODS: A total of 118 exposed and 208 control infants were followed from birth for at least 2 years. Assessment of infection in children and computation of transmission rate were made according to the European Economic Community/World Health Organization Ghent guidelines (1992). RESULTS: The transmission rate was 40.4% [95% confidence interval (CI), 30.7-50.1]. Maternal age, parity, history of adverse pregnancy outcome or history of decreased children were not associated with transmission. However, independently, women whose relationship with their infant's father was less than 1 year, or women who had symptoms of HIV-1 during pregnancy had an increased risk of transmission [adjusted odds ratios, 11.1 (95% CI, 2.4-50.2) and 10.3 (95% CI, 2.9-37.1), respectively]. CONCLUSION: The transmission rate observed in Congo is in the upper range of the rates reported in Africa. The uneven distribution of cofactors for perinatal transmission, such as the presence of symptoms of HIV disease during pregnancy, may explain some of the variation observed across studies.

Bacillus Calmette-Guérin immunization in infants born to HIV-1-seropositive mothers.

During the prospective follow-up of 64 babies at risk for perinatal HIV-1 infection because their mothers were seropositive, and of 130 control babies whose mothers were seronegative, we studied the occurrence of complications of bacillus Calmette-Guérin (BCG) immunization and its ability to induce cutaneous reactivity to tuberculin. Babies born both to HIV-1-positive and HIV-1-negative mothers received BCG immunization during their first month of life according to the Expanded Programme on Immunization (EPI) recommendations. Local and regional complications of BCG vaccine were looked for at 3, 6 and 9 months after inoculation. A tuberculin skin test was performed at 6 or 9 months of age. Most babies born to HIV-1-positive mothers were later classified as infected or uninfected according to their clinical condition and/or serological status at 18 months of age. The mean duration of the follow-up was 36 months (range 30-40 months). No chronic or deep ulcerations at the site of injection or disseminated forms of BCG infection were observed. The frequency of BCG-related lymphadenitis in the group of HIV-1-infected children (24%) did not differ significantly from the group of uninfected children (19%; Fisher test: P = 0.73). In contrast, the tuberculin skin test responses were positive less often in the group of HIV-1-infected children (33%) than in the uninfected group (83%; Fisher test: P = 0.007). Because BCG vaccine appears to be safe--even when given to perinatally infected babies--continuation of the BCG immunization policies of the EPI is justified, especially in view of the growing incidence of tuberculosis as a complication of HIV infection.

Mother-child transmission of HIV-1 and infant survival in Brazzaville, Congo.

The aim of this study was to compare the probability of survival of infants born to anti-HIV-1-positive and anti-HIV-1-negative mothers. One thousand, eight hundred and thirty-three pregnant women, recruited sequentially in two mother-child clinics in Brazzaville, were screened for anti-HIV-1 (by enzyme-linked immunosorbent assay with confirmation by Western blot). Each seropositive mother (71 out of 1833, 3.9%) was matched for age, presumed date of delivery and place of residence with two seronegative mothers. Sixty-four babies born to anti-HIV-1-positive mothers and 130 control babies born to anti-HIV-1-negative mothers were followed up for 12-22 months (mean, 18 months). The probabilities of survival were estimated by the Kaplan-Meier method. At birth, the two groups of babies did not differ with regard to rate of stillbirths, gestational age, sex ratio and weight. Among babies born to seropositive mothers, the probability of survival was 0.87 (s.d. 0.04) at 3 months, 0.71 (s.d. 0.06) at 6 months, 0.68 (s.d. 0.06) at 9 months and 0.61 (s.d. 0.06) at 12.5 months. In the controls the probability of survival was 0.98 (s.d. 0.01) at 3 months and 0.97 (s.d. 0.02) at 12 months. The excess of mortality in the babies born to anti-HIV-1-positive mothers is highly significant (P less than 0.001). The deaths occurred more frequently and earlier than in similar cohort studies performed in developed countries.

Characteristics associated with HIV-1 infection in pregnant women in Brazzaville, Congo.

Maternal human immunodeficiency virus type 1 (HIV-1) infection in sub-Saharan Africa is a major public health concern because of the high prevalence among women of childbearing age and the poor prognosis for perinatally infected children. Characteristics associated with HIV seroprevalence were studied in a population of 1,833 pregnant women seen in two large mother-child clinics in Brazzaville, Congo. The prevalence of HIV infection was 3.9% (95% confidence interval, 3.0-4.9%) and differed significantly according to the district of residence, marital status, duration of the relationship with the current partner, number of sexual partners in the year prior to pregnancy, number of living and dead children, and history of blood transfusion and/or hospitalization. Logistic regression analysis identified six significant factors independently associated with seropositivity; age, history of blood transfusion and/or hospitalization, district of residence, duration of the relationship, number of living children, and number of decreased children. However, the predictive value of the model was poor: while 80% of the truly positive women were correctly predicted positive by the model, 50% of the truly negative women were misclassified. Among pregnant women attending these clinics it is therefore difficult to identify a subgroup at risk toward which specific actions could be targeted.

Cerebral malaria in African children: socioeconomic risk factors in Brazzaville, Congo.

Current epidemiologic and clinical research on cerebral malaria is directed towards prognostic criteria and neurologic sequelae. However, the assessment of risk factors related to the environment and the socioeconomic standard of the family is of practical as well as theoretical interest. A prospective survey was carried out in March 1990 in Brazzaville, Congo by interviewing subjects in two groups: 1) 600 households representative of the Brazzaville population and 2) 84 households with a child who had been hospitalized for cerebral malaria between January 1, 1988 and June 30, 1989 (i.e., 9-27 months prior to the interview). The mothers' knowledge and attitudes with regard to the prevention and treatment of malaria in children were assessed, as was the socioeconomic standards of the households. The group in which at least one child had been hospitalized for cerebral malaria had a lower socioeconomic standard than the control group. Other differences in this group included a greater number of offspring and a higher average number of decreased children, less chemoprophylaxis, antimalarials available less often in the household, less early treatment of fever at home, and drugs bought more often at the market. There was no significant difference between the groups with regard to using the correct dosage of chloroquine, ownership of a mosquito net, or the use of insecticides or repellents.

PIP: The aim was to compare a cerebral malaria group (B) with a control group (A) representative of the entire population of Brazzaville. Group A was composed of mothers with at least 1 child younger than 10 years old living in the urban district of Brazzaville. 30 clusters of 20 households totalling 600 were selected from the 1984 population census. Group B was composed of Brazzaville children who had been admitted to the University Hospital for cerebral malaria between January 1, 1988, and June 30, 1989. Of the 170 children for whom precise hospital records were available 145 were discharged from the hospital. In the 1st quarter of 1990 a family-based survey was carried out on 84 households to study postcerebral malaria mortality analyzing: 1) the preventive and therapeutic measures taken by mothers, and 2) the socioeconomic standards of the families in 68 and 84 households, respectively. The socioeconomic standard of group B was lower than that of group A. Those with less than a primary school education constituted: 502 (84%) in 600 controls vs. 61 (73%) in 84 cases (p = 0.02 odds ratio [OR] = 1.9). For 461 controls (77%) vs. 47 cases (56%), mothers had a good comprehension of French (p = 0.0007, OR = 2.3). The other differences were that Group B had a greater number of children, a higher average number of deceased children, less use of chemoprophylaxis, antimalarials available less often in the household, less early treatment of fever at home, and the purchase of drugs more often at the market. However, significant differences were not found with respect to owning a mosquito net or the use of insecticides and repellents.

Malaria and urbanization in central Africa: the example of Brazzaville. Part V: Pernicious attacks and mortality.

The current incidence of pernicious attacks and of mortality due to malaria were studied in Brazzaville. The results of this study, which concerned all the medical units of the town, were analysed in terms of previous studies on the epidemiology of malaria transmission in the various districts of the town. It was estimated that the annual incidence of pernicious attacks in children in Brazzaville is 1.15 per thousand between 0 and 4 years, 0.25 per thousand between 5 and 9 years and 0.05 per thousand between 10 and 14 years. The annual mortality due to malaria was estimated at 0.43 per thousand between 0 and 4 years and 0.08 per thousand between 5 and 9 years. These values are about 30 times lower than those expected from the results of previous studies of the mortality due to malaria in intertropical Africa. Whereas considerable differences in intensity of malaria transmission exist in the different districts of Brazzaville, the incidence of pernicious attacks and the resulting mortality are remarkably unvarying whatever the level of transmission. In particular, similar results were observed for the sector Mfilou-Ngamaba-Ngangouoni, where malaria is holoendemic with over 100 infective bites per person per year and a parasite rate of 80.95% in schoolchildren, and the central sector of Poto-Poto-Ouenze-Moungali, where malaria is hypoendemic with less than one infective bite per person every three years and a parasite rate of less than 4% in schoolchildren. These results are discussed in terms of previous observations in urban and surrounding rural areas.(ABSTRACT TRUNCATED AT 250 WORDS)

[An epidemiological study of consultations of children under 5 years of age in Brazzaville (Congo)]. / Etude épidémiologique des consultations d'enfants de moins de 5 ans à Brazzaville (Congo).

In most of the large cities in developing countries, geographic accessibility to health care is not a major problem. Thus, indifference to public services and a preference for home treatment, recourse to traditional medicine or to the private sector may be related to problems in the quality of services. A cross-sectional epidemiological study of hospital visits by under-5 children was carried out in health centres and hospital out-patient services in Brazzaville (Congo). Sampling in these health facilities was done using a systematic random sample with a proportion of 25%, during 4 periods chosen according to seasonal factors. An exhaustive investigation of the entire public sector serving children was done in the study. At the same time, the same data were gathered in a sample of private facilities (doctors' and nurses' offices, traditional healers, religious healing centres), chosen as a function of their permanence and the numbers of their clientele. This article analyses services offered during 2215 visits by children, who were under 1 year of age in more than 50% of cases. In the public sector, 75% of visits were to first-line health centres. Public services show marked dysfunctions: the complexity of internal referrals, clinical examinations which are inadequate in relation to symptoms, and poor communication (explanations as to cause of illness in less than 2% of cases, and on treatments in less than 50% of cases). Communication seems well developed among private physicians and traditional healers, the latter engaging in both preventive and curative activities. Communication during well-child visits and consultations at health centres is especially disappointing, in light of the very young age of the parents (1/4 are high-school or college students). There is a two-fold risk in this situation: flight towards non-conventional medicine on the one hand, and access to private medicine based on socio-economic status on the other. It thus appears necessary to standardise procedures and acts in first line public health services and to promote training of personnel in communication skills with families (training using social science perspectives and participative pedagogical techniques).

[Anemia and growth in Congolese adolescents with homozygous sickle cell anemia at Central University Hospital of Brazzaville]. / Anémie et croissance chez l'adolescent congolais drépanocytaire homozygote au CHU de Brazzaville.

The rate of hemoglobin of 71 homozygous sickle cell disease patients from 10 to 18 years was studied, as well as the mean cell volume for 61 of them. Their height, weight and bone age were compared. The rate of hemoglobin in steady state is 6.5 g/dl +/- 2.3 for girls against 7.9 g/dl +/- 1.5 for boys. There's no significant difference between the rate of hemoglobin on sexual maturation state for girls. But the boys from 14 to 18 years old with signs of sexual maturation had higher rate of hemoglobin than those had not (8.5 g/dl +/- 1.3 against 6.3 g/dl +/- 1.5). Eighteen per cent of patients with homozygous sickle cell disease had a MCV superior to 100 mu 3; 57% are between 80 to 100 mu 3 and 25% under 80 mu 3. Patients with higher MCV to 100 mu 3 had low weight and height than those with inferior MCV to 80 mu 3 or 80 and 100 mu 3. Their sexual maturation is delayed with very low bone age and elevated number of hospitalisation and transfusion. Their delay of maturation was very high too. The supplementation with folic acid can lead to reduction of MCV.

[AIDS at Central University Hospital of Brazzaville: experience of the "Grands Enfants" pediatric department]. / Le SIDA au CHU de Brazzaville: expérience du service de pédiatrie "Grands enfants".

The epidemiological factors, clinical aspects and short term evolution of children infected by aids were assessed over a period of five years in "Grands Enfants" paediatric service of Brazzaville CHU. The medical reports of 81 patients have been collected, their average age was 9 years old +/- 3.5. The HIV 1 was the only identified virus. 59% of children's parents were divorced, and 7% were single. The infection transmission was vertical in 70% of cases, transfusional in 28% of cases and indeterminate in 1% of cases. The symptoms were: the impairment of body status in 90% of cases, shown by a weight loss in 89% of cases; a long-term fever was observed in 56% of cases and a chronic diarrhoea was noticed in 54% of cases. The lymphadenopathies and digestive Candida were observed in 26% and 36% of cases. 6% of the patients had a psychomotor retardation. The respiratory infections and the diarrhoea were pathologies the most frequently noticed. The associated infections were essentially pulmonary tuberculosis 40% of cases, the otitis, the pneumococcal and cryptococcal meningia 2% of cases. The Burkitt lymphoma and the Kaposi sarcoma were shown in 1% of cases. The evolution was shown by a high mortality due to a dehydration in 59% of cases, a respiratory pathology in 22% of cases and anaemia in 15% of cases. This high mortality points out the problem of the treatment of patients, a problem increased by family poverty.

[Value of a mass vaccination campaign: measles cases in the hospital milieu in Brazzaville (Congo)]. / Intérêt d'une campagne de vaccination de masse: cas de la rougeole en milieu hospitalier a Brazzaville (Congo).

In November 1986, Congo got up an immunization for measles of nine to 36 months old infants. The aim of this study was to compare the morbidness and the death rate of measles in a 20 months period before and after November 1986. The infants less than nine months old constituted 57.2% of the patients admitted after November 86 opposed to 19, 5% before November 86. The authors stand out for strategies that will let to immunize 97% of the infants.

[Clinical presentation of non-pernicious malaria attacks in patients hospitalized in Brazzaville (Congo) in 1989]. / Présentation clinique des accès palustres non pernicieux hospitalisés a Brazzaville (Congo) en 1989.

The clinical manifestations observed in 102 malaria patients (parasitaemia of over 8,000 Plasmodium falciparum/mm3) hospitalized in 1989 in Brazzaville (Congo) were analyzed after ruling out the cases of pernicious malaria. The clinical picture was fever, stomach upset with headache and musculo-articular pain as in classical cases. In children these manifestations were frequently associated with convulsions. Diarrhoea was not uncommon in young children. Vomiting was frequent in both children and adults. Splenomegaly and hepatomegaly were closely related to age. In these subjects, chemoprophylaxis was rare in children, practically non-existent in those aged over 5 years. However, presumptive treatment and self medication was usual regardless of age.