1.
Bioorg Med Chem Lett
; 28(11): 2000-2002, 2018 06 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29752183
RESUMO
We identified novel (3R, 5S)-3-aminomethyl-5-methanesulfanyl hexanoic acid (5a: DS75091588) and (3R, 5S)-3-aminomethyl-5-ethanesulfanyl hexanoic acid (6a: DS18430756) as sulfur-containing γ-amino acid derivatives that were useful for the treatment of neuropathic pain. These two compounds exhibited a potent analgesic effect in animal models of both type I diabetes and type II diabetes, and good pharmacokinetics.
Assuntos
Canais de Cálcio/metabolismo , Diabetes Mellitus Experimental/tratamento farmacológico , Diabetes Mellitus Tipo 1/tratamento farmacológico , Diabetes Mellitus Tipo 2/tratamento farmacológico , Neuralgia/tratamento farmacológico , Compostos de Sulfidrila/farmacologia , Animais , Caproatos/química , Caproatos/farmacologia , Diabetes Mellitus Experimental/metabolismo , Diabetes Mellitus Tipo 1/metabolismo , Diabetes Mellitus Tipo 2/metabolismo , Modelos Animais de Doenças , Ligantes , Camundongos , Estrutura Molecular , Neuralgia/metabolismo , Compostos de Sulfidrila/química
2.
Angew Chem Int Ed Engl
; 52(44): 11607-11, 2013 Oct 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24014169
RESUMO
Rise and shine: Using a gene-targeting approach aimed at identifying potential L-threonine:uridine-5'-transaldolases that catalyze the formation of (5'S,6'S)-C-glycyluridine, a new bacterial translocaseâ I inhibitor was discovered from an actinomycete following fermentation optimization.