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1.
J Med Internet Res ; 21(12): e15870, 2019 12 09.
Artigo em Inglês | MEDLINE | ID: mdl-31815676

RESUMO

BACKGROUND: The recently developed blockchain technology uses a peer-to-peer network to distribute data to all participants for storage. This method enhances data safety, reliability, integrity, and transparency. To successfully introduce blockchain technology to medical data management, it is essential to obtain consent from medical doctors and patients. OBJECTIVE: The aim of this study was to examine medical doctors' and patients' attitudes toward the use of blockchain technology and interpret the findings within the framework of expectancy theory. METHODS: In this questionnaire survey, we examined medical doctors' (n=90) and patients' (n=90) attitudes toward the use of blockchain technology in the management and distribution of medical information. The questionnaire comprised 8 questions that assessed attitudes toward new means of managing and distributing medical information using blockchain technology. Responses were rated on a scale that ranged from 1 (very negative) to 7 (very positive). RESULTS: Medical doctors (mean 3.7-5.0) reported significantly more negative attitudes than patients (mean 6.3-6.8). Furthermore, self-employed doctors reported more negative attitudes than employed doctors and university professors. CONCLUSIONS: To successfully introduce blockchain technology to medical data management, it is necessary to promote positive attitudes toward this technology among medical doctors, especially self-employed doctors.


Assuntos
Atitude do Pessoal de Saúde , Blockchain , Pacientes Internados , Médicos , Adulto , Gestão da Informação em Saúde , Humanos , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , República da Coreia , Inquéritos e Questionários
2.
Int Arch Occup Environ Health ; 90(6): 501-506, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28321491

RESUMO

PURPOSE: To assess female healthcare workers' pregnancy complications and outcomes including abortion, fetal screening abnormalities, intrauterine growth retardation (IUGR), and preterm labor using nationwide population data and compare these results with those of the general population in Korea. METHODS: Korean National Health Insurance (NHI) claim data was used. We choose 3 different reference groups for comparison: (1) dependents of employees insured by NHI, i.e. non-working women, (2) all insured employees, i.e. all working women, and (3) workers in the education division. To compare the groups, logistic regression was used for multivariate analysis after adjusting for age and income level. RESULTS: Overall, healthcare workers showed a higher adjusted OR (odds ratio) in almost all obstetrical consequences. Miscarriage, threatened abortion, preterm labor, fetal screening abnormalities, and IUGR showed a higher adjusted OR in the working group than in the non-working group. We also observed similar results in a comparison of both the working groups. Regarding workers in the education division, ORs for obstetrical outcomes were also high, except for preterm labor. CONCLUSIONS: Health care workers have a higher risk of adverse pregnancy outcomes such as miscarriage, IUGR, and fetal screening abnormalities.


Assuntos
Pessoal de Saúde , Exposição Ocupacional/efeitos adversos , Complicações na Gravidez/epidemiologia , Complicações na Gravidez/etiologia , Resultado da Gravidez/epidemiologia , Adulto , Bases de Dados Factuais , Feminino , Humanos , Recém-Nascido , Modelos Logísticos , Análise Multivariada , Programas Nacionais de Saúde , Gravidez , República da Coreia/epidemiologia , Adulto Jovem
3.
Int Arch Occup Environ Health ; 89(5): 739-53, 2016 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-26821358

RESUMO

PURPOSE: Occupational risks for reproductive disorders among hairdressers and cosmetologists have been examined in numerous epidemiological studies, although the results of those studies have been inconsistent. Therefore, we conducted a meta-analysis of published studies to evaluate the risks of reproductive disorders among cosmetologists and hairdressers. METHODS: We searched the MEDLINE, EMBASE, and Cochrane Library databases, as well as the reference lists of relevant publications, to identify studies for our analysis. After careful consideration, 19 eligible studies were included in the meta-analysis. We also performed systematic evaluations of publication bias, heterogeneity, and publication quality. RESULTS: Study-specific odds ratios (ORs) were weighted using the inverse of their variance to calculate fixed- and random-effect pooled estimates. The meta-analysis revealed a significantly increased risk of infertility (OR 1.15, 95 % CI 1.03-1.28), fetal death (OR 1.14, 95 % CI 1.04-1.24), and preterm delivery (OR 1.04, 95 % CI 1.00-1.07) among hairdressers and cosmetologists. CONCLUSION: These findings indicate that hairdressers and cosmetologists have a higher risk of reproductive disorders, compared to the general population.


Assuntos
Barbearia , Indústria da Beleza , Cosméticos/efeitos adversos , Infertilidade/etiologia , Doenças Profissionais/etiologia , Exposição Ocupacional/efeitos adversos , Feminino , Morte Fetal/etiologia , Humanos , Razão de Chances , Gravidez , Nascimento Prematuro/etiologia , Fatores de Risco
5.
Opt Express ; 23(6): 7333-44, 2015 Mar 23.
Artigo em Inglês | MEDLINE | ID: mdl-25837076

RESUMO

An asymmetric polarization-based frequency scanning interferometer is proposed using the asymmetric polarimetric method. The proposed system controls the polarization direction of the beam using a polarizer and wave plate, along with a conventional interferometer system. By controlling the wave plate, it is possible to asymmetrically modulate the magnitude of the object and reference beam, which are divided by the polarizing beam splitter. Based on this principle, if the target object consists of both transparent and opaque parts with different polarization characteristics, each part can be measured. After a fast Fourier transform of the acquired interference signal, the shape of the object is obtained by analyzing its spectrum. The proposed system is evaluated in terms of measurement accuracy and noise robustness through a series of experiments to show the effectiveness of the system.

6.
Neuroradiology ; 57(2): 189-96, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25308621

RESUMO

INTRODUCTION: Microembolic signal (MES) monitoring with transcranial Doppler ultrasonography (TCD) may allow for early prediction of thromboembolisms following endovascular coiling of unruptured intracranial aneurysms (UIAs). However, the method has not gained widespread use and may benefit from correlation with diffusion-weighted imaging (DWI) of acute ischemic lesions after coiling. This purposed to evaluate the relationship between MESs and DWI-positive lesions more precisely. METHODS: We conducted a prospective study on 45 consecutive patients. TCD was performed over the artery that is dependent on the site of aneurysm, but seven patients (15.6%) could not be examined due to the lack of an adequate cranial window. Consequently, 38 patients were available to detect MESs immediately (MES-1) and 24 h (MES-2) after coiling for UIAs. We also checked DWI 1 day after the coiling and analyzed correlations between the TCD and DWI findings. RESULTS: MES-1 and MES-2 were positive in 25 (65.7%) and 14 (36.8%) patients, respectively. DWI-positive lesions were seen in 20 (52.6%) patients, and only 1 (2.6%) patient was symptomatic. MES-1 and MES-2 were strongly correlated with the number of DWI-positive lesions (Spearman's correlation coefficient = 0.79 and 0.70, P < 0.01 and P < 0.01, respectively). Additionally, there was a significant correlation between MES-1 and MES-2 (Spearman's correlation coefficient = 0.70). CONCLUSION: Based upon the significant correlation between MES and DWI findings, MES may have a role for early detection of ischemic complications after coiling of UIAs. In addition, future study for further validation with clinical application seems requiring.


Assuntos
Imagem de Difusão por Ressonância Magnética/métodos , Aneurisma Intracraniano/terapia , Embolia Intracraniana/diagnóstico , Embolia Intracraniana/etiologia , Trombólise Mecânica/efeitos adversos , Ultrassonografia Doppler Transcraniana/métodos , Aneurisma Roto/complicações , Feminino , Humanos , Aneurisma Intracraniano/complicações , Aneurisma Intracraniano/diagnóstico , Angiografia por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Estatística como Assunto , Resultado do Tratamento
7.
Acta Neurochir (Wien) ; 157(5): 769-71, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25646849

RESUMO

BACKGROUND: One of the most difficult procedures through a deep and narrow surgical corridor is tying a knot following microsuturing, even though microvascular suturing is a fundamental technique for neurovascular surgeons. METHODS: A novel technique replacing the conventional knot-tying method was devised. The proposed clip-knotting technique uses an aneurysm clip to hold both remaining ends of a thread that is sutured in a running manner. CONCLUSIONS: The proposed clip-knotting technique can facilitate the microsuturing procedure for intracranial arterial repair in a deep and narrow operative field.


Assuntos
Encéfalo/cirurgia , Técnicas de Sutura/instrumentação , Encéfalo/irrigação sanguínea , Humanos , Instrumentos Cirúrgicos , Técnicas de Sutura/efeitos adversos , Suturas
8.
Acta Neurochir (Wien) ; 157(4): 699-702, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25619775

RESUMO

BACKGROUND: While frameless stereotaxis can be used for shunt ventricular catheter placement in patients with smaller ventricles, the ventricular catheter is still commonly placed based on the surface anatomy of the head for patients with larger ventricles. Thus, surgical techniques and guides facilitating accurate and reliable freehand placement of the ventricular catheter still need to be devised. METHODS: With the patient in a supine position and the axis of their head maintained horizontally, the guiding protractor is placed horizontally in the frontal burrhole at Kocher's point. Using the guiding angle between the head axis and the frontal horn of the lateral ventricle based on coronal head computed tomography (CT) or magnetic resonance (MR) images, the ventricular catheter is then placed in the catheter guide within the guiding protractor. RESULTS: In 20 hydrocephalic patients with a bicaudate index >0.2 or bifrontal distance >25 mm, the ideal guiding angle ranged from 17 to 23° (mean ± standard deviation [SD], 19.6° ± 1.6°). In all these patients, ventricular catheterization was successfully achieved with only one pass of the catheter, and postoperative CT scans showed satisfactory placement of the catheter in the ipsilateral frontal horn of the lateral ventricles. CONCLUSIONS: The proposed surgical technique using a guiding protractor facilitates accurate freehand placement of a ventricular catheter for patients with a bicaudate index >0.2 or bifrontal distance >25 mm.


Assuntos
Cateterismo/métodos , Hidrocefalia/cirurgia , Neuronavegação/métodos , Derivação Ventriculoperitoneal/métodos , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X
9.
Acta Neurochir (Wien) ; 156(9): 1655-61, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-24950994

RESUMO

BACKGROUND: While advanced age is already recognized as an independent risk factor for a poor functional outcome following an aneurysmal subarachnoid hemorrhage (SAH), it is also important to investigate the critical age for defining a higher risk population among elderly patients and the clinical grade at admission in order to provide a prognostic description and help guide the management of patients aged ≥ 70 years. METHODS: This retrospective study included 165 patients aged 70-90 years who underwent surgical or endovascular treatment for a ruptured aneurysm. In addition to medical and radiological data, telephone interviews were used to obtain the 1-year functional outcome. RESULTS: A multivariate analysis revealed age (p = 0.001) and the World Federation of Neurological Surgeons (WFNS) grade (p = 0.001), regardless of the treatment modalities (surgical versus endovascular), as significant risk factors for a poor outcome, while a receiver operating characteristic analysis revealed 75 years as an appropriate cutoff value for the patient age to predict a poor 1-year functional outcome (area under the curve: 0.683). For the patients aged 70-75 years with good (1-3) and poor (4-5) WFNS grades, 81.9 % and 42.9 % achieved a favorable outcome (modified Rankin Scale 0-3), respectively, whereas for the patients over the critical age (> 75 years) with good and poor WFNS grades, 54.8 % and 5.9 % achieved a favorable outcome, respectively. CONCLUSIONS: The long-term outcome for elderly patients with an aneurysmal SAH is affected primarily by the clinical condition at admission and the patient's age in relation to the critical age (> 75 years), regardless of the treatment modalities, including surgical clipping and endovascular coiling.


Assuntos
Aneurisma Roto/mortalidade , Aneurisma Roto/terapia , Aneurisma Intracraniano/mortalidade , Aneurisma Intracraniano/terapia , Hemorragia Subaracnóidea/mortalidade , Hemorragia Subaracnóidea/terapia , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Avaliação da Deficiência , Feminino , Humanos , Masculino , Análise Multivariada , Prognóstico , Curva ROC , Estudos Retrospectivos , Instrumentos Cirúrgicos , Análise de Sobrevida , Resultado do Tratamento
10.
Acta Neurochir (Wien) ; 156(11): 2041-9; discussion 2049, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-25085542

RESUMO

BACKGROUND: An intra-arterial (IA) mechanical thrombectomy has increased the recanalization rates for acute occlusion of proximal intracranial arteries. However, the current failure rate of endovascular recanalization remains at approximately 10%, resulting in the need for surgical rescue treatment. The authors applied a minimally invasive and rapid surgical embolectomy (MIRSE) as a final rescue treatment after the failure of endovascular recanalization, and investigated the incidence, technical feasibility, and treatment results. METHODS: For two years, from 2012 to 2013, a total of 131 patients with acute occlusion of proximal intracranial arteries underwent an IA mechanical thrombectomy using a Penumbra System and a Solitaire stent, yet ten (7.6%) patients still experienced final recanalization failure. Four (40%) of these ten patients subsequently underwent a MIRSE consisting of a superciliary keyhole approach, arteriotomy to remove the embolus, and arteriotomy repair techniques using aneurysm clips as the final repair material, or a temporary compartmentalizing clip. RESULTS: Four patients aged 39 to 78 years with an embolic occlusion in the middle cerebral artery (n = 1) and internal carotid artery (n = 3) were treated using a MIRSE. Complete recanalization was achieved in all four patients, and the time from skin incision to reperfusion was 40-50 minutes. The modified Rankin Scale (mRS) scores at 3 months after surgery were 1 (n = 2), 2 (n = 1), and 3 (n = 1), respectively. CONCLUSIONS: A MIRSE can be an effective rescue treatment after the failure of endovascular recanalization therapies for acute occlusion of proximal intracranial arteries if the patient is within the therapeutic time window.


Assuntos
Isquemia Encefálica/cirurgia , Artéria Carótida Interna/cirurgia , Embolectomia/métodos , Artéria Cerebral Média/cirurgia , Acidente Vascular Cerebral/cirurgia , Adulto , Idoso , Isquemia Encefálica/complicações , Procedimentos Endovasculares , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Procedimentos Cirúrgicos Minimamente Invasivos , Duração da Cirurgia , Estudos Retrospectivos , Stents , Acidente Vascular Cerebral/etiologia , Trombectomia/métodos , Falha de Tratamento , Resultado do Tratamento
11.
World Neurosurg ; 189: 256-263, 2024 Jun 26.
Artigo em Inglês | MEDLINE | ID: mdl-38942145

RESUMO

OBJECTIVE: To design and evaluate ceramic aneurysm clips with integrated titanium springs, focusing on ergonomic application and precision in neurosurgical procedures. METHODS: The clip design was executed with precision using Creo Parametric 3D CAD software. It comprises a zirconia body and a titanium spring for durability and consistent tension and features a four-coil hairpin titanium spring for enhanced closing force and a ball-type head for versatile maneuverability during surgery. To assess durability, closing forces were rigorously measured using a force gauge system, comparing the ceramic clip with the standard Mizuho permanent clip over 30 open-close cycles. For the assessment of magnetic resonance (MR) artifacts, both the ceramic and Yasargil clips were evaluated using a 3 Tesla (T) MRI scanner, employing specific imaging sequences. RESULTS: The straight type ceramic clip's initial closing force was 1.70 N, dropping to 1.22 N after 30 cycles, indicating a retention of 72% of its initial force. In MRI, the ceramic clip displayed significantly lower measurement discrepancies compared to the titanium alloy Yasargil clip, particularly in high-resolution T1-weighted images. The lowest variance was at measurement point L2, where the ceramic clip showed a 3% discrepancy. Furthermore, the ceramic clip yielded clearer images than the titanium alloy clip, particularly at the clip's end. CONCLUSIONS: Ceramic clips with titanium springs demonstrated satisfactory closing force and superior MRI compatibility, promising enhancements in surgical application and postoperative assessment.

12.
Artigo em Inglês | MEDLINE | ID: mdl-38751045

RESUMO

This is the first report of the successive development and rupture of blister-like anterior communicating artery (ACoA) aneurysms at mirror locations with a short interval. A 49-year-old man presented with an angiogram-negative subarachnoid hemorrhage with significant basal frontal interhemispheric blood. Surgical exploration revealed a blister-like aneurysm on the left side of the superior wall of the ACoA, which was treated using a microsuturing technique. On the 18th day after the initial subarachnoid hemorrhage, the second operation due to another angiogram-negative hemorrhage revealed a de novo blister-like aneurysm with a small blood clot on the posterosuperior wall of the ACoA close to the right A1/A2 junction. The rupture point and ACoA on the right side were occluded using an aneurysm clip. Follow-up digital subtraction angiogram (DSA) at 4 years and computed tomography angiogram (CTA) at 14 years after the surgery showed no recurrence or associated abnormality.

13.
World Neurosurg ; 187: e1072-e1082, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38750889

RESUMO

OBJECTIVE: This study describes our experiences with anterior choroidal artery (AChA) aneurysm clipping with a focus on visualizing the AChA just behind the aneurysm to identify the risk factors for adhesion of the AChA or its branches to the posterior wall of the AChA aneurysm. METHODS: The initial segment of the AChA just behind the aneurysm was evaluated preoperatively using three-dimensional (3D) rotational angiography, and its course was designated as posteromedial, posterior, or posterolateral. The posterior aspect of the AChA aneurysm was inspected intraoperatively using an endoscope or micromirror. RESULTS: Based on 3D rotational angiography, the main trunk of the AChA showed a posteromedial (n = 47, 57.3%), posterior (n = 18, 22.0%), or posterolateral (n = 17, 20.7%) course just behind the aneurysm. Intraoperatively, 14.6% (12 of 82) of the clipped AChA aneurysms revealed an AChA branch adhered to the posterior wall of the aneurysm. A multivariate analysis revealed that the posterior or posterolateral course of the initial segment of the AChA was a statistically significant risk factor for adhesion of an AChA branch to the posterior wall of the aneurysm (odds ratio [OR] 21.083, 95% confidence interval [CI] 2.567-173.166, P = 0.005). CONCLUSIONS: The initial course of the AChA just behind an AChA aneurysm can be evaluated using 3D rotational angiography. In contrast to a posteromedial course, a posterior or posterolateral course of the AChA just behind an AChA aneurysm can be a significant risk factor for adhesion of an AChA branch to the posterior wall of an AChA aneurysm.


Assuntos
Angiografia Cerebral , Imageamento Tridimensional , Aneurisma Intracraniano , Humanos , Aneurisma Intracraniano/cirurgia , Aneurisma Intracraniano/diagnóstico por imagem , Feminino , Masculino , Angiografia Cerebral/métodos , Pessoa de Meia-Idade , Idoso , Imageamento Tridimensional/métodos , Adulto , Procedimentos Neurocirúrgicos/métodos , Instrumentos Cirúrgicos
14.
Artigo em Inglês | MEDLINE | ID: mdl-38825744

RESUMO

Objective: Reconstruction methods, including stent-assisted coiling, multiple telescopic stents, and flow diverters, are preferred modalities for the treatment of unruptured vertebral artery dissecting aneurysms (VADAs). We aimed to compare the clinical outcomes between two reconstructive flow diversion techniques: single flow diverter (FD) device and multiple telescopic stenting (TS). Methods: We retrospectively reviewed the clinical data of 39 patients with unruptured VADAs. Of these, 17 patients were treated with multiple TS and 22 with a single FD device. Aneurysm characteristics and clinical outcomes were compared between the two groups. Results: All aneurysms included in this study successfully achieved flow diversion, regardless of the treatment modality and duration. However, the mean procedure duration to complete the diversion was shorter in the FD group. Subgroup analysis in TS group showed that there were no significant clinical differences between the low-profile visualized intraluminal support and Enterprise stents, except for the mean procedure duration. Conclusions: Both the single FD and multiple TS methods showed excellent angiographic and clinical outcomes in the treatment of unruptured VADAs. However, single FD required a shorter procedure duration and was associated with faster achievement of complete flow diversion.

15.
J Clin Neurol ; 20(3): 293-299, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38330418

RESUMO

BACKGROUND AND PURPOSE: The purpose of this study was to describe the clinical presentation and features in electrodiagnostic and imaging investigations of young South Korean males diagnosed with Hirayama disease (HD). METHODS: We reviewed the electronic medical records of South Korean enlisted soldiers who were diagnosed with HD and discharged from military service during 2011-2021. We investigated the clinical characteristics and results of electrodiagnostic and magnetic resonance imaging (MRI) investigations. We analyzed laterality and identified the involved muscles using needle electromyography (EMG). Loss of lordosis, localized cervical cord atrophy, loss of attachment between the posterior dura and subjacent lamina, asymmetric flattening of the cord, crescent-shaped mass in the posterior epidural space, and noncompressive intramedullary T2-weighted high signal intensity were investigated using neutral- or flexion-position MRI. RESULTS: Forty-two male patients aged 20.2±0.8 years (mean±standard deviation) were identified. All patients complained of hand weakness, and 10 complained of hand tremor (23.8%). Four patients (9.5%) had symptoms in both upper limbs, and five (11.9%) had sensory disturbances. Needle EMG revealed that muscles in the C7-T1 myotome were commonly involved, and C5-C6 involvement of the deltoid (10.5%) and biceps brachii (12.5%) was also observed. In cervical MRI, localized cord atrophy (90.0%) was the most characteristic finding, and cord atrophy was most severe at the C5-C6 level (58.3%). CONCLUSIONS: This is the first description of a large number of patients with HD in South Korea. The clinical presentation and features found in electrodiagnostic and imaging investigations will improve the understanding of HD in the young South Korean male population.

16.
Stroke ; 44(12): 3577-9, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-24021683

RESUMO

BACKGROUND AND PURPOSE: We introduce the concept of a switching strategy for mechanical thrombectomy with period-to-period analysis. In period 1, forced arterial suction thrombectomy with a Penumbra reperfusion catheter was performed, even in difficult cases; in period 2, forced arterial suction thrombectomy was initially performed, with switching to Solitaire in difficult cases. METHODS: We analyzed 135 consecutive patients treated with mechanical thrombectomy with acute large vessel occlusion in the anterior circulation, 61 from period 1 and 74 from period 2. We defined difficult case for both periods as ≥3 failed attempts at recanalization. RESULTS: Period 2 showed a trend for better angiographic outcome of Thrombolysis in Cerebral Infarction 2b-3 (73.8%, period 1 versus 85.1%, period 2; P=0.10). In interperiod subgroup analysis of difficult cases, switching significantly outperformed nonswitching in Thrombolysis in Cerebral Infarction 2b-3 recanalization (52.7% versus 82.9%; P=0.030). Differences in puncture-to-recanalization time, symptomatic intracranial hemorrhage incidence, and procedure-related complications were not statistically significant. CONCLUSIONS: A switching strategy using 2 mechanical thrombectomy techniques (forced arterial suction thrombectomy to Solitaire) may harbor better angiographic outcomes than a 1 technique only strategy (forced arterial suction thrombectomy).


Assuntos
Isquemia Encefálica/cirurgia , Trombose Intracraniana/cirurgia , Acidente Vascular Cerebral/cirurgia , Trombectomia/métodos , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Stents , Trombectomia/instrumentação , Resultado do Tratamento
17.
Stroke ; 44(3): 789-91, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-23204052

RESUMO

BACKGROUND AND PURPOSE: The aims of this study are to evaluate the risk factors for symptomatic ischemic complication (symptomatic ischemic complication [SIC], transient ischemic attack, or stroke) and microembolisms detected as MR diffusion-weighted imaging (MR-DWI)-positive (DWI(+)) lesions, and the relationship between DWI(+) and SIC after coiling of unruptured intracranial aneurysm. METHODS: Between March 2009 and November 2011, 382 unruptured intracranial aneurysms in 343 patients underwent both coiling and posttreatment MR-DWI. The incidence of and risk factors for SIC and DWI(+), and the relationship between DWI(+) and SIC were retrospectively analyzed. RESULTS: The incidence of SIC was 4.1%. The incidence of DWI(+) was 54.5%. The number of DWI(+) lesions was significantly larger in the SIC group, than in the asymptomatic one (12.1±10.4 versus 5.0±8.7, P<0.00). The cutoff value of DWI(+) for predicting SIC was ≥6 (sensitivity 85.7%, specificity 70.7%). The patients with DWI(+) ≥6 was 28.6%. Of the patients with SIC, the patients with DWI(+) ≥6 was 78.6%. Patients aged≥65 years had a trend for SIC, and it was the only independent risk factor for DWI(+) ≥cutoff (n=6; 95%CI, 1.167-3.083). CONCLUSIONS: The number of DWI(+) lesions was significantly larger in the SIC group than in the asymptomatic one after coiling of unruptured intracranial aneurysm. Patients aged≥65 had a trend for SIC, and it was the only independent risk factor for the number of DWI(+) ≥cutoff value (n=6) for predicting SIC.


Assuntos
Imagem de Difusão por Ressonância Magnética , Embolização Terapêutica/efeitos adversos , Aneurisma Intracraniano/terapia , Ataque Isquêmico Transitório/epidemiologia , Ataque Isquêmico Transitório/patologia , Acidente Vascular Cerebral/epidemiologia , Acidente Vascular Cerebral/patologia , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Embolização Terapêutica/instrumentação , Embolização Terapêutica/métodos , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Risco , Sensibilidade e Especificidade
18.
J Neuroinflammation ; 10: 21, 2013 Feb 04.
Artigo em Inglês | MEDLINE | ID: mdl-23374901

RESUMO

BACKGROUND: Hypothermic protection against ischemic stroke has been reported by many studies. Hypothermia is supposed to mitigate the effects of deleterious genes and proteins and promote the activity of protective genes and proteins in the ischemic brain. Metallothionein (MT)-1/2 is thought to be a crucial factor for metal homeostasis, immune function, and apoptosis. This protein was found to exert protective effects in models of brain injury as well. In the present study, we investigated the effect of hypothermia on MT expression and the underlying mechanisms. METHODS: Cultured bEnd.3 brain endothelial cells were exposed to oxygen glucose deprivation and reperfusion (OGD+R). Reverse transcription PCR and western blot analyses were performed to measure the expression of MT, transcription factors, and methylation regulating factors. Transcription factor binding assays were also performed. Methylation profiles of the promoter area were obtained with pyrosequencing. RESULTS: Hypothermia protected bEnd.3 cells from OGD+R. When the cells were exposed to OGD+R, MT expression was induced. Hypothermia augmented MT levels. While OGD+R-induced MT expression was mainly associated with metal regulatory transcription factor 1 (MTF-1), MT expression promoted by hypothermia was primarily mediated by the signal transducer and activator of transcription 3 (STAT3). Significantly increased STAT3 phosphorylation at Ser727 was observed with hypothermia, and JSI-124, a STAT-3 inhibitor, suppressed MT expression. The DNA demethylating drug 5-aza-2'-deoxycytidine (5-Aza) enhanced MT expression. Some of the CpG sites in the promoter MT=> it should be "the CpG sites in the MT promoter" showed different methylation profiles and some methylation regulating factors had different expressional profiles in the presence of OGD+R and hypothermia. CONCLUSIONS: We demonstrated that hypothermia is a potent inducer of MT gene transcription in brain endothelial cells, and enhanced MT expression might contribute to protection against ischemia. MT gene expression is induced by hypothermia mainly through the STAT3 pathway. DNA methylation may contribute to MT gene regulation under ischemic or hypothermic conditions.


Assuntos
Encéfalo/metabolismo , Células Endoteliais/metabolismo , Hipotermia Induzida/métodos , Metalotioneína/biossíntese , Animais , Hipóxia Celular/fisiologia , Linhagem Celular Transformada , Sobrevivência Celular/fisiologia , Técnicas de Silenciamento de Genes/métodos , Humanos , Camundongos
19.
Acta Neurochir (Wien) ; 155(8): 1583-8, 2013 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-23689967

RESUMO

BACKGROUND: Among the procedural complications related to carotid artery stenting (CAS), internal carotid artery (ICA) flow arrest is one of the most drastic complications, as it can cause major ischemic stroke. Acute carotid stent thrombosis (ACST) is a rare etiology of ICA flow arrest during carotid artery stenting with distal filter protection, but the most devastating. Moreover, no definitive management strategy has been established so far for treating ACST. METHODS: We introduce a rescue management strategy for differential diagnosis of ICA flow arrest and for recanalization of ACST with a simple endovascular mechanical thrombectomy technique. RESULTS: In three cases of ICA flow arrest caused by ACST, selective angiography with a 1.7 F microcatheter provided confirmative diagnosis. Recanalization was then achieved with a Penumbra System (PS) reperfusion catheter using the forced arterial suction thrombectomy (FAST) technique. Successful recanalization with a Thrombolysis In Cerebral Infarction score of 3 was achieved for all three patients. Recanalization was confirmed with follow-up angiography at least 24 h after the procedure. No complications associated with this technique occurred. CONCLUSIONS: Based on our preliminary experiences, selective microangiography can be helpful for rapid diagnosis of ACST, and the present mechanical thrombectomy technique, using a modification of the PS, can play a role in adjuvant management or as a last resort for the treatment of ACST during CAS.


Assuntos
Trombose das Artérias Carótidas/cirurgia , Artéria Carótida Primitiva/cirurgia , Artéria Carótida Interna/cirurgia , Stents/efeitos adversos , Trombectomia , Doença Aguda , Idoso , Angiografia/métodos , Catéteres , Filtração/instrumentação , Humanos , Masculino , Pessoa de Meia-Idade , Sucção/instrumentação , Trombectomia/métodos
20.
J Korean Neurosurg Soc ; 66(1): 105-110, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36625015

RESUMO

A diagnosis of an intracranial aneurysm depends on the angiographic configuration and should be cautiously differentiated from aneurysm mimics. In cases of duplicate anterior choroidal arteries (AChAs), infundibular widening of the distal minor AChA can be an aneurysm mimic. If the minor AChA with a smaller diameter is obscured angiographically due to poor contrast filling, an associated infundibular widening beside the proximal large AChA can misinterpreted as a typical AChA aneurysm in angiograms. The authors report on two such cases of duplicate AChAs with infundibular widening presenting like a typical AChA aneurysm in angiograms. Surgical exploration revealed a perforating artery emitting from the dome of the saccular lesion, confirming infundibular widening of a duplicate AChA. No reparative procedure was applied to the infundibular widening in a 48-year-old man, while two vascular outpouchings from the infundibular widening were clipped preserving the duplicate AChA in a 55-year-old woman.

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