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1.
Euro Surveill ; 18(8)2013 Feb 21.
Artigo em Inglês | MEDLINE | ID: mdl-23449231

RESUMO

On 24 October 2012, a patient with acute respiratory distress syndrome of unknown origin and symptom onset on 5 October was transferred from Qatar to a specialist lung clinic in Germany. Late diagnosis on 20 November of an infection with the novel Coronavirus (NCoV) resulted in potential exposure of a considerable number of healthcare workers. Using a questionnaire we asked 123 identified contacts (120 hospital and three out-of-hospital contacts) about exposure to the patient. Eighty-five contacts provided blood for a serological test using a two-stage approach with an initial immunofluorescence assay as screening test, followed by recombinant immunofluorescence assays and a NCoV-specific serum neutralisation test. Of 123 identified contacts nine had performed aerosol-generating procedures within the third or fourth week of illness, using personal protective equipment rarely or never, and two of these developed acute respiratory illness. Serology was negative for all nine. Further 76 hospital contacts also tested negative, including two sera initially reactive in the screening test. The contact investigation ruled out transmission to contacts after illness day 20. Our two-stage approach for serological testing may be used as a template for similar situations.


Assuntos
Busca de Comunicante , Infecções por Coronavirus/diagnóstico , Coronavirus/isolamento & purificação , Transmissão de Doença Infecciosa do Paciente para o Profissional/prevenção & controle , Síndrome do Desconforto Respiratório/etiologia , Coronavirus/genética , Coronavirus/imunologia , Infecções por Coronavirus/complicações , Infecções por Coronavirus/epidemiologia , Infecções por Coronavirus/terapia , Diagnóstico Tardio , Notificação de Doenças , Feminino , Técnica Indireta de Fluorescência para Anticorpo , Alemanha , Pessoal de Saúde/estatística & dados numéricos , Humanos , Transmissão de Doença Infecciosa do Paciente para o Profissional/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Testes de Neutralização , Exposição Ocupacional , Catar , Reação em Cadeia da Polimerase em Tempo Real , Síndrome do Desconforto Respiratório/epidemiologia , Estudos Retrospectivos , Medição de Risco , Fatores de Risco , Inquéritos e Questionários , Viagem , Resultado do Tratamento
2.
Dtsch Med Wochenschr ; 139(7): 323-6, 2014 Feb.
Artigo em Alemão | MEDLINE | ID: mdl-24496893

RESUMO

HISTORY: In February 2013, 5 patients in an intensive care unit (ICU) were found to have positive blood cultures with Ralstonia pickettii within one week. Because all patients got intravenous therapy, improper work of a staff member was suspected. Some days later, a 6th patient was found with a positive blood culture of Ralstonia pickettii in another department of the hospital. INVESTIGATIONS: Hygienic investigations showed no evidence of failures in preparation of intravenous therapy. All patients were on different intravenous drugs, but every patient had received glucose 5 % and magnesium. We examined samples of glucose and magnesia as well as samples from environment. RESULTS AND COURSE: Glucose and magnesium samples were examined by membrane filter method. Ralstonia pitteckii was detected in some Magnesium vials. We concluded, that contamination of Magnesium vials might have been the reason for blood stream infection of patients. Pharmacists and authorities were informed and all vials were collected and replaced by vials from another company. Later a nationwide recall of Magnesium vials was performed by the producing company. No further Ralstonia pickettii was found in blood cultures in our hospital. CONCLUSION: Unusual pathogens in blood cultures should lead to reflection of rarer causes such as contamination of medicines.


Assuntos
Surtos de Doenças/prevenção & controle , Contaminação de Medicamentos/prevenção & controle , Embalagem de Medicamentos , Infecções por Bactérias Gram-Negativas/sangue , Infecções por Bactérias Gram-Negativas/prevenção & controle , Magnésio/uso terapêutico , Ralstonia pickettii/isolamento & purificação , Infecção Hospitalar/microbiologia , Infecção Hospitalar/prevenção & controle , Surtos de Doenças/estatística & dados numéricos , Contaminação de Medicamentos/estatística & dados numéricos , Infecções por Bactérias Gram-Negativas/diagnóstico , Humanos
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