RESUMO
Borago officinalis L., an annual herb belonging to the Boraginaceae family, is used in the traditional medical practices of various countries and for multiple treatments, including respiratory disorders, colds, influenza, diarrhea, cramps, inflammation, palpitation, hypertension menopause, and post-menopausal symptoms. Its pharmacological properties and biological activities - among them antioxidant, antimicrobial, anticancer, anti-inflammatory, insecticidal, antigenotoxic, and anti-obesity activity - were demonstrated inâ vitro and inâ vivo and are related to its rich content of bioactive compounds (mainly phenolic acids, flavonoids, anthocyanins, alkaloids, and terpenes) extracted from various parts of B. officinalis including leaves, flowers, seeds, and roots. This review summarizes all updated information on applied extraction processes, phytochemistry, pharmacology, and toxicity of B. officinalis.
Assuntos
Borago , Compostos Fitoquímicos , Extratos Vegetais , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Extratos Vegetais/isolamento & purificação , Humanos , Compostos Fitoquímicos/farmacologia , Compostos Fitoquímicos/isolamento & purificação , Compostos Fitoquímicos/química , Borago/química , Animais , Anti-Inflamatórios/farmacologia , Anti-Inflamatórios/isolamento & purificação , Anti-Inflamatórios/química , Anti-Infecciosos/farmacologia , Anti-Infecciosos/química , Anti-Infecciosos/isolamento & purificação , Antioxidantes/farmacologia , Antioxidantes/química , Antioxidantes/isolamento & purificaçãoRESUMO
This work aimed to investigate, for the first time, the chemical composition, antioxidant, antiparasitic, cytotoxicity, and antimicrobial activities of the aromatic plant Limonium oleifolium Mill. essential oil (EO) and organic extracts. L.â oleifolium aerial parts essential oil was analyzed by GC-FID and GC-MS, and 46 constituents representing 98.25±1.12 % of the oil were identified. γ-Muurolene (10.81±0.07 %), cis-caryophyllene (7.71±0.06 %), o-cymene (7.07±0.01 %) and α-copaene (5.02±0.05 %) were the essential oil main compounds. The antioxidant activity of L.â oleifolium EO and organic extracts (MeOH, CHCl3 , AcOEt, BuOH) was explored using 2,2-diphenyl-1-picrylhydrazyl (DPPH), ABTS, ß-carotene/linoleic acid, cupric reducing antioxidant capacity (CUPRAC), and ferric reducing power assays. The results showed that L.â oleifolium EO exhibit antioxidant capacity (IC50 =17.40±1.32â µg/mL for DPPH assay, IC50 =29.82±1.08â µg/mL for ß-carotene assay, IC50 =25.23±1.01â µg/mL for ABTS assay, IC50 =9.11±0.08â µg/mL for CUPRAC assay and IC50 =19.41±2.06â mg/mL for reducing power assay). Additionally, the EO showed significant activity against trophozoite form of Acanthamoeba castellanii (IC50 =7.48±0.41â µg/mL) and promastigote form of Leishmania amazonensis (IC50 =19.36±1.06â µg/mL) and low cytotoxicity on murine macrophages (LC50 â 90.23±1.09â µg/mL), as well as good antimicrobial activity against Staphylococcus aureus, Escherichia coli, Klebsiella oxytoca, and Pseudomonas aeruginosa. These results suggest that L.â oleifolium essential oil is a valuable source of bioactive compounds presenting antioxidant, antiparasitic, and antimicrobial activities. Furthermore, it is considered nontoxic.
Assuntos
Antibacterianos/farmacologia , Antioxidantes/farmacologia , Antiparasitários/farmacologia , Extratos Vegetais/farmacologia , Plumbaginaceae/química , Acanthamoeba castellanii/efeitos dos fármacos , Animais , Antibacterianos/química , Antibacterianos/isolamento & purificação , Antioxidantes/química , Antioxidantes/isolamento & purificação , Antiparasitários/química , Antiparasitários/isolamento & purificação , Bactérias/efeitos dos fármacos , Benzotiazóis/antagonistas & inibidores , Compostos de Bifenilo/antagonistas & inibidores , Linhagem Celular , Sobrevivência Celular/efeitos dos fármacos , Leishmania/efeitos dos fármacos , Macrófagos/efeitos dos fármacos , Camundongos , Testes de Sensibilidade Microbiana , Testes de Sensibilidade Parasitária , Picratos/antagonistas & inibidores , Extratos Vegetais/química , Extratos Vegetais/isolamento & purificação , Ácidos Sulfônicos/antagonistas & inibidoresRESUMO
In the current study, we examined the chemical makeup and anti-oxidant potential of an Algerian Leopoldia comosa. The results showed that there were moderate levels of phenols and flavonoids in the crude extract (15.11 ± 0.78 µg GAE/mg and 31.27 ± 2.71 µg QE/mg, respectively). Additionally, the findings showed that both crude extract and EO had moderate antioxidant capabilities (8.74 ± 1.13 mg/ml; 13.18 ± 0.18% and 12.94 ± 0.89%, respectively). Twelve (12) volatile compounds were found in the EO according to GC-MS and GC-FID analyses, with tetrapentacontane (48.25%), 3,7,11,15-tetramethyl-2-hexadecen-1-ol (16.59%), hexatriacontane (9.17%), and 6,10,14-trimethylpentadecan-2-one (8.80%) accounting for the majority of the components. To our knowledge, no earlier studies have looked at the chemical composition of L. comosa oil. These findings might contribute to our understanding of this species' makeup and make it a useful source of food and medicine in the future.