Survival of Patients with Cystic Fibrosis Depending on Mutation Type and Nutritional Status.

The purpose of the study was to evaluate the influence of nutrition and of the severity of mutation type on survival rate in cystic fibrosis (CF) patients. Data were longitudinally collected from 60 hospitalized adult CF patients, aged 18-50. The variables consisted of body mass index (BMI) ratio, Cole's BMI cut-off points, severity of mutation type, and survival rate of CF patients. We found that the mean BMI was strongly associated with the severity of mutation type and was significantly lower in patients with severe mutations of grade I and II. The mutation type significantly affected the patients' survival rate; survival was greater in patients with mild and undefined mutation types. The BMI and Cole's cut-off points also had a significant influence on survival rate. CF patients, who suffered from malnutrition and emaciation, had a shorter survival rate than those with proper nutritional status. In conclusion, the study findings confirmed a significant effect of nutritional status and of mutation type on survival rate of CF patients.

Influence of Body Shape Composition on Respiratory Function in Adult Women.

The purpose of the study was to evaluate the influence of body size and shape, and of fat distribution on respiratory functions in adult women. The sample consisted of 107 women aged 17-82 years. Height, weight, chest, waist and hip circumferences, abdominal, and subscapular and triceps skinfolds were examined. The BMI and WHR were calculated. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), peak expiratory flow (PEF), maximal expiratory flow (MEF75), forced expiratory time (FET) were used as measures of respiratory function. Positive correlations were found between z-scores of height and VC, FEV1, FVC, between WHR and VC, and between circumference and FET. Negative correlations were found between z-scores of BMI and VC, FEV1, between subscapular skinfold and VC, FEV1, FVC and between abdominal skinfold and VC. Stepwise multiple regression analysis showed that traits of body size and shape mostly influenced VC (32 %) and FVC (31 %). Body height and WHR significantly affected VC, while height and subscapular skinfold affected FVC. A significant association between fat distribution described by BMI, WHR, and skinfold thickness and respiratory parameters was observed. These results confirm a complex effect of body size and shape, and of fat distribution on respiratory function.

Body mass index, waist to hip ratio and waist/height in adult Polish women in relation to their education, place of residence, smoking and alcohol consumption.

Obesity is a complex, multifactorial disorder that develops from genotype and environmental interactions. The aim of this study is to describe the variability of body mass index (BMI), waist to hip ratio (WHR) and waist to height (W/Ht) in adult Polish women, and to determine relationships between these variables and factors such as education, place of residence, smoking and alcohol drinking. The tested group consisted of 10,254 women aged 25-95 years, who voluntarily filled in questionnaires and participated in anthropometric measurements (body height and mass, waist and hip circumferences). The BMI, WHR and W/Ht values were calculated based on these measurements. The participants were differentiated in terms of education, residence and lifestyle (smoking, alcohol drinking). Chi-squared test, product-moment correlations, ANOVA, multiple correspondence analysis (MCA) and logistic regression with backward elimination were used to evaluate associations between social and lifestyle factors and BMI, WHR and W/Ht. The results confirm (1) the relationship between low social status and the risk of overweight and obesity as observed in developed countries; (2) higher susceptibility to environmental factors such as education, place of residence, smoking and alcohol drinking in younger (premenopausal) women; (3) the usefulness of simple and practical anthropometric indicators such as WHR and W/Ht for the identification of the higher risk of future metabolic diseases in obese people and those with a normal body mass.

Assessment of the body mass index and selected physiological parameters in pre- and post-menopausal women.

The main purpose of this paper is to describe the variability of the body mass index (BMI) and selected physiological parameters (serum glucose, total serum cholesterol, systolic and diastolic blood pressure) in women before and after menopause. The empirical basis for the assessment is the material obtained in cross-sectional studies carried out in the years 1998-2001 in a group of 2204 women aged 35-65 years, residents of the Wielkopolska region, Poland. The results indicate that hormonal changes taking place in the climacterium bring about an increase in the BMI. It was observed that women receiving Hormone Replacement Therapy in the perimenopause had BMI significantly lower than naturally menopausal women. Increased levels of total serum cholesterol and blood glucose were recorded. The trend has a stronger relation with the age of the subjects than with the character of the menopause. The systolic and diastolic blood pressure values were also found to increase significantly after the menopause, but no relationship with the type of menopause was found.

The 2nd:4th digit ratio, sexual dimorphism, population differences, and reproductive success. evidence for sexually antagonistic genes?

The ratio between the length of the 2nd and 4th digit (2D:4D) is sexually dimorphic, with mean male 2D:4D lower than mean female 2D:4D. It recently was suggested that 2D:4D is negatively correlated with prenatal testosterone and positively correlated with prenatal estrogen. It is argued that high prenatal testosterone and low estrogen (indicated by low 2D:4D) favors the male fetus and low prenatal testosterone and high estrogen (indicated by high 2D:4D) favors the female fetus. The patterns of expression of 2D:4D are interpreted in terms of sexually antagonistic genes.We report data on the following. (a) reproductive success and 2D:4D from England, Germany, Spain, Hungary (ethnic Hungarians and Gypsy subjects), Poland, and Jamaica (women only). Significant negative associations were found between 2D:4D in men and reproductive success in the English and Spanish samples and significant positive relationships between 2D:4D in women and reproductive success in the English, German, and Hungarian samples. The English sample also showed that married women had higher 2D:4D ratios than unmarried women, suggesting male choice for a correlate of high ratio in women, and that a female 2D:4D ratio greater than male 2D:4D predicted high reproductive success within couples. Comparison of 2D:4D ratios of 62 father:child pairs gave a significant positive relationship. This suggested that genes inherited from the father had some influence on the formation of the 2D:4D ratio. Waist:hip ratio in a sample of English and Jamaican women was negatively related to 2D:4D. (b) Sex and population differences in mean 2D:4D in samples from England, Germany, Spain, Hungary (including ethnic Hungarians and Gypsy subjects), Poland, Jamaica, Finland, and South Africa (a Zulu sample). Significant sex and population differences in mean 2D:4D were apparent.

The central action of gamma-aminobutyric acid in rats.

The influence of 100--600 microng of gamma-aminobutyric acid (GABA) injected into the right lateral ventricle of the brain on behavior and activity of the cerebral cholinergic system was studied in Wistar rats. Proportionally to dosage, GABA inhibited motor and exploratory activity in the rats. Reduction in the content of acetylcholine in the pons and medulla oblongata was accompanied by increased acetylcholinesterase (AChE) activity. GABA changed AChE activity differently in various parts of the brain. GABA depressed motor and exploratory activity in rats in a degree dependent on its dosage and inborn exploratory of the rats, and this effect was accompanied by changes in the cerebral cholinergic system.

[Comparative studies of adverse effects in patients with refractory depression treated with amitryptyline, mianserin and unilateral ECT]. / Porównanie objawów niepozadanych u pacjentów z lekooporna depresja leczonych amitryptylina, mianseryna lub elektrowstrzasami jednostronnymi.

The comparative studies of side effects in 180 patients with refractory depression treated with amitriptyline, mianserin and unilateral ECT were performed.

Biological maturity at birth, the course of the subsequent ontogenetic stages and age at menarche.

The main aim of the study was to assess the influence of biological maturity at birth on growth processes in the subsequent years and during puberty in girls. The material of this study comes from the outpatient clinic cards and cross-sectional research on girls from the province of Wielkopolska in Poland. It includes data of 527 girls. The influence of perinatal maturity on body weight in the later stages of ontogeny was determined with the use of the Kruskal-Wallis test and the Mann-Whitney U test. In order to determine the relationship between perinatal maturity and age at menarche, the survival analysis module was used. The results show a diverse influence of perinatal maturity on the values of body weight achieved in later years of life. The indicated predictive factors included both birth weight and gestational age. In the examined girls menarche occurred between the 10th year and the 17th year of life (X¯=12.87, s=1.26; Me=13 years). The comparison showed a significant variation in age at menarche depending on the length of pregnancy (log-rank χ(2)(2)=27.068, p<0.0001) and birth weight (log-rank χ(2)(2)=23.241, p<0.0001). There was no variation in maturation of the examined girls conditioned by the occurrence of intra-uterine growth retardation (log-rank χ(2)(2)=2.046, p>0.05). Remote prognoses as to the postnatal development of preterm-born children and/or children with low birth weight indicate adverse influence of these variables on age at menarche. Perinatal biological maturity of a newborn conditions the course of postnatal development.

Biological status of adult patients with cystic fibrosis.

Cystic fibrosis (CF) is the most common autosomal disorder in the Caucasian population. The main goal of the study was to assess the biological condition of adult patients with CS. Data of 90 CF patients aged 18-31 were considered. The biological condition was determined by the measurement of somatometric traits and the nutritional status. The results show a considerable physical retardation and a poor nutritional status of the studied patients. Nearly 45% of the patients showed symptoms of malnutrition, ranging from slight undernutrition to emaciation. The results, however, show a considerable variability of data among the CF patients compared with the healthy population. A significant relationship between the type of mutation and nutritional status was demonstrated.