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1.
Opt Express ; 31(24): 39396-39414, 2023 Nov 20.
Artigo em Inglês | MEDLINE | ID: mdl-38041262

RESUMO

Optical holographic encryption (OHE) has been extensively researched in the field of information security due to its parallel and multi-dimensional characteristics. However, although some progress in OHE has been made in recent years, inherent security flaws resulting from the robust nature of holograms persist. In this study, we propose a multilevel holographic encryption method based on the Tiger Amulet (TA) concept. Compared with the normal OHE, our method employs two ciphertexts. It strategically utilizes the low-level plaintext as intentional deceptive content to confound the potential eavesdroppers. Furthermore, we ingeniously exploit the hologram's robustness in reverse, thereby establishing an additional protection mechanism to enhance the security of the middle-level plaintext. Leveraging the TA concept, the high-level plaintext can only be decrypted when two matched ciphertexts are combined and collimated. The TA based decryption mechanism enhances the security and sensitivity deciphering high-level plaintext. Benefiting from the security mechanisms above, our proposed method demonstrates promising applicability across diverse scenarios and holds the potential to redefine the landscape of multilevel OHE design.

2.
Opt Express ; 31(13): 21507-21520, 2023 Jun 19.
Artigo em Inglês | MEDLINE | ID: mdl-37381248

RESUMO

Optical encryption has been extensively researched in the field of information security due to its characteristics of being parallel and multi-dimensionsal. However, most of the proposed multiple-image encryption systems suffer from a cross-talk problem. Here, we propose a multi-key optical encryption method based on a two-channel incoherent scattering imaging. In the encryption process, plaintexts are coded by the random phase mask (RPM) in each channel and then coupled by an incoherent superposition to form the output ciphertexts. In the decryption process, the plaintexts, keys, and ciphertexts, are treated as a system of two linear equations with two unknowns. By utilizing the principles of linear equations, the issue of cross-talk can be mathematically resolved. The proposed method enhances the security of the cryptosystem through the quantity and order of the keys. Specifically, the key space is significantly expanded by removing the requirement of uncorrected keys. This approach provides a superior method that can be easily implemented in various application scenarios.

3.
Opt Express ; 31(9): 14081-14095, 2023 Apr 24.
Artigo em Inglês | MEDLINE | ID: mdl-37157279

RESUMO

Herein, we propose a super-oscillation optical field foveated local super-resolution imaging method. Firstly, the post-diffraction integral equation of the foveated modulation device is constructed, the objective function and constraints are established, and the structural parameters of the amplitude modulation device are optimally solved by using genetic algorithm. Secondly, the solved data have been input into the software for point diffusion function analysis. We have studied the super-resolution performance of different ring band amplitude types, and find the 8-ring 0-1 amplitude type has the best super-resolution performance. Finally, the principle experimental device is built according to the simulation parameters, and the super-oscillatory device parameters is loaded onto the amplitude type spatial light modulator for the principle experiments, in which the super-oscillation foveated local super-resolution imaging system is able to perform high image contrast imaging in the whole field of view and super-resolution imaging in the foveated field of view area. As a result, this method achieves the 1.25 times super-resolution magnification in the foveated field of view area, which realizes the super-resolutio n imaging of local field while keeping the resolution of other fields unchanged. Experiments verify the feasibility and effectiveness of our system.

4.
Opt Lett ; 48(19): 5125-5128, 2023 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-37773401

RESUMO

In the current image fusion techniques, typically dual-band images are fused to obtain a fused image with salient target information, or intensity and polarization images are fused to achieve an image with enhanced visual perception. However, the current lack of dual-band polarization image datasets and effective fusion methods pose significant challenges for extracting more information in a single image. To address these problems, we construct a dataset containing intensity and polarization images in the visible and near-infrared bands. Furthermore, we propose an end-to-end image fusion network using attention mechanisms and atrous spatial pyramid pooling to extract key information and multi-scale global contextual information. Moreover, we design efficient loss functions to train the network. The experiments verify that the proposed method achieves better performance than the state-of-the-art in both subjective and objective evaluations.

5.
Chemistry ; 29(27): e202203839, 2023 May 11.
Artigo em Inglês | MEDLINE | ID: mdl-36793258

RESUMO

Ultrasensitive electrochemical detection on hazardous substances like antibiotics and pesticides is essential but still challenging in rapid test technology. Herein, the first electrode using highly conductive metal-organic frameworks (HCMOFs) for electrochemical detection of chloramphenicol is proposed. The design of electrocatalyst Pd(II)@Ni3 (HITP)2 with ultra-sensitivity in detection of chloramphenicol is demonstrated by loading Pd onto HCMOFs. An ultra-low limit of detection (LOD) of 0.2 nM (64.6 pg/mL) was observed for these materials, which is 1-2 orders of magnitude lower than the other reported materials for chromatographic detection. Moreover, the proposed HCMOFs showed long-time stability over 24 h. The superior detection sensitivity can be attributed to the high conductivity of Ni3 (HITP)2 , and the large Pd loading. The experimental characterizations and computational investigation determined the Pd loading mechanism in Pd(II)@Ni3 (HITP)2 , revealing PdCl2 adsorption on the abundant adsorption sites of Ni3 (HITP)2 . The proposed electrochemical sensor design using HCMOFs was demonstrated to be both effective and efficient, showing that the adoption of HCMOFs decorated with other effective electrocatalysts, which combine high conductivity and high catalytic activity, is of great advantage for ultrasensitive detection.

6.
Radiology ; 299(1): E167-E176, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33231531

RESUMO

Background There are characteristic findings of coronavirus disease 2019 (COVID-19) on chest images. An artificial intelligence (AI) algorithm to detect COVID-19 on chest radiographs might be useful for triage or infection control within a hospital setting, but prior reports have been limited by small data sets, poor data quality, or both. Purpose To present DeepCOVID-XR, a deep learning AI algorithm to detect COVID-19 on chest radiographs, that was trained and tested on a large clinical data set. Materials and Methods DeepCOVID-XR is an ensemble of convolutional neural networks developed to detect COVID-19 on frontal chest radiographs, with reverse-transcription polymerase chain reaction test results as the reference standard. The algorithm was trained and validated on 14 788 images (4253 positive for COVID-19) from sites across the Northwestern Memorial Health Care System from February 2020 to April 2020 and was then tested on 2214 images (1192 positive for COVID-19) from a single hold-out institution. Performance of the algorithm was compared with interpretations from five experienced thoracic radiologists on 300 random test images using the McNemar test for sensitivity and specificity and the DeLong test for the area under the receiver operating characteristic curve (AUC). Results A total of 5853 patients (mean age, 58 years ± 19 [standard deviation]; 3101 women) were evaluated across data sets. For the entire test set, accuracy of DeepCOVID-XR was 83%, with an AUC of 0.90. For 300 random test images (134 positive for COVID-19), accuracy of DeepCOVID-XR was 82%, compared with that of individual radiologists (range, 76%-81%) and the consensus of all five radiologists (81%). DeepCOVID-XR had a significantly higher sensitivity (71%) than one radiologist (60%, P < .001) and significantly higher specificity (92%) than two radiologists (75%, P < .001; 84%, P = .009). AUC of DeepCOVID-XR was 0.88 compared with the consensus AUC of 0.85 (P = .13 for comparison). With consensus interpretation as the reference standard, the AUC of DeepCOVID-XR was 0.95 (95% CI: 0.92, 0.98). Conclusion DeepCOVID-XR, an artificial intelligence algorithm, detected coronavirus disease 2019 on chest radiographs with a performance similar to that of experienced thoracic radiologists in consensus. © RSNA, 2020 Supplemental material is available for this article. See also the editorial by van Ginneken in this issue.


Assuntos
Inteligência Artificial , COVID-19/diagnóstico por imagem , Pulmão/diagnóstico por imagem , Interpretação de Imagem Radiográfica Assistida por Computador/métodos , Radiografia Torácica/métodos , Algoritmos , Conjuntos de Dados como Assunto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , SARS-CoV-2 , Sensibilidade e Especificidade , Estados Unidos
7.
Biometrics ; 77(2): 465-476, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-32687215

RESUMO

We propose a new procedure for inference on optimal treatment regimes in the model-free setting, which does not require to specify an outcome regression model. Existing model-free estimators for optimal treatment regimes are usually not suitable for the purpose of inference, because they either have nonstandard asymptotic distributions or do not necessarily guarantee consistent estimation of the parameter indexing the Bayes rule due to the use of surrogate loss. We first study a smoothed robust estimator that directly targets the parameter corresponding to the Bayes decision rule for optimal treatment regimes estimation. This estimator is shown to have an asymptotic normal distribution. Furthermore, we verify that a resampling procedure provides asymptotically accurate inference for both the parameter indexing the optimal treatment regime and the optimal value function. A new algorithm is developed to calculate the proposed estimator with substantially improved speed and stability. Numerical results demonstrate the satisfactory performance of the new methods.


Assuntos
Algoritmos , Teorema de Bayes , Simulação por Computador , Intervalos de Confiança
8.
BMC Infect Dis ; 21(1): 56, 2021 Jan 12.
Artigo em Inglês | MEDLINE | ID: mdl-33435880

RESUMO

BACKGROUND: Hepatitis B virus (HBV) infection is a high-risk factor of hepatocellular carcinoma (HCC). Cellular immune responses are essential for HCC development, and the CD4+ and CD8+ T subtypes are identified as the primary anti-tumor immune cells. In the study, we investigated the effect and mechanism of amygdalin in the cellular immune response in HBV-related HCC and HCC progression. METHODS: The cell proliferation was examined by MTT analysis. Cells metastasis ability was detected by Invasion and migration assays. Quantification of apoptotic cells was performed with Flow cytometer assay. The protein levels of p-STAT3, STAT3, p-JAK2, JAK2, caspase-3, cleaved caspase-3 were detected by performing immunoblotting assays. RESULTS: We demonstrate that amygdalin treatment could rescue the HBV-T cell viability and IFN-γ and TNF-αproduction. In HBV-T cells, the MFI levels of CD8+ are lower than that in NC-T cells. Moreover, the phosphorylation levels of STAT3 and JAK2 are higher in HBV-T cells, compared to those in NC-T cells, and then reduced by amygdalin treatment. Co-culture with HBV-T cells could reduce IFN-γ and TNF-α, production while increase IL-6 and IL-10 production in HepG2.2.15 cells; these alterations could be partially reversed by amygdalin pretreatment. Finally, co-culture with HBV-T cells significantly promoted the cell viability, inhibited the apoptosis, and promoted the migration of HepG2.2.15 cells, and these alterations could be partially reversed by amygdalin treatment. CONCLUSION: Our findings provide a rationale for further studies on the functions and mechanism of amygdalin inhibiting HBV-related HCC cell proliferation, invasion, and migration via T cell-mediated tumor immunity.


Assuntos
Amigdalina/farmacologia , Carcinoma Hepatocelular/sangue , Carcinoma Hepatocelular/virologia , Progressão da Doença , Hepatite B/complicações , Janus Quinase 2/metabolismo , Neoplasias Hepáticas/sangue , Neoplasias Hepáticas/virologia , Fator de Transcrição STAT3/metabolismo , Transdução de Sinais/efeitos dos fármacos , Linfócitos T/efeitos dos fármacos , Idoso , Amigdalina/metabolismo , Apoptose/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Técnicas de Cocultura , Citocinas/metabolismo , Feminino , Células Hep G2 , Hepatite B/virologia , Vírus da Hepatite B/fisiologia , Humanos , Masculino , Pessoa de Meia-Idade , Linfócitos T/metabolismo , Linfócitos T/virologia
9.
RSC Adv ; 14(10): 6494-6500, 2024 Feb 21.
Artigo em Inglês | MEDLINE | ID: mdl-38390502

RESUMO

Thermally activated delayed fluorescence (TADF) molecules have emerged as a promising class of third-generation organic light-emitting diode (OLED) emitters that can achieve 100% internal quantum efficiency without the use of noble metals. However, the design of high-efficiency red TADF materials has been challenging due to limitations imposed by the energy-gap law. To overcome this challenge, two new TADF emitters, namely, 6-(4-(diphenylamino)phenyl)-2-phenyl-1H-benzo[de]isoquinoline-1,3(2H)-dione (NI-TPA) and 6-(10H-phenothiazin-10-yl)-2-phenyl-1H-benzo[de]-isoquinoline-1,3(2H)-dione (NI-Pz), have been synthesized and characterized. These compounds exhibit strong TADF characteristics with a small energy gap (ΔEST) between the lowest excited singlet and triplet states, short delayed fluorescence lifetimes, high thermal stability, and high photoluminescence quantum yields. The OLED devices fabricated using NI-TPA and NI-Pz as emitters show orange and red electroluminescence with emission peaks at 593 nm and 665 nm, respectively, and maximum external quantum efficiencies (EQEs) of 11.3% and 7.6%, respectively. Furthermore, applying NI-TPA to cell imaging yielded excellent imaging results, indicating the potential of red TADF materials in the field of biological imaging.

10.
RSC Adv ; 14(25): 17434-17439, 2024 May 28.
Artigo em Inglês | MEDLINE | ID: mdl-38813129

RESUMO

In this study, we developed a D-A type imide derivative based on 1,8-naphthalimide, NI-mPCz, which exhibited outstanding thermally activated delayed fluorescence (TADF) properties. Additionally, it demonstrates characteristics of piezochromic and thermochromic luminescence. The thermochromic luminescence observed is attributed to crystalline transformations occurring during the heating process, as evidenced by differential scanning calorimetry (DSC) and microscopic examinations. Moreover, the good compatibility of NI-mPCz with HeLa cells and its excellent imaging performance indicate its potential for application in the field of biological imaging. These results provide valuable insights for the design and development of new organic electronic and bioimaging materials with high-efficiency TADF characteristics.

11.
Hum Cell ; 37(4): 1156-1169, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38814517

RESUMO

To explore the effects of ß-Sitosterol upon hepatocellular carcinoma cell proliferation, apoptosis, migration, invasion, and epithelial-mesenchymal transition (EMT), and to investigate the underlying mechanism using network pharmacology. Human hepatocellular carcinoma cell lines (Huh-7 and HCCLM3) were expose to gradient concentrations of ß-Sitosterol (5 µg/mL, 10 µg/mL, and 20 µg/mL). Cell viability and proliferation were assessed using MTT, CCK-8, colony formation, and EdU assays.Flow cytometry was employed to evaluate cell cycle and apoptosis. Scratch and Transwell assays were performed, respectively, to detect cell migration and invasion. The levels of apoptosis-associated proteins (BAX, BCL2, and cleaved caspase3) as well as EMT-associated proteins (E-cadherin, N-cadherin, Snail, and Vimentin) were detected in Huh-7 and HCCLM3 cell lines using Western blot analysis. The drug target gene for ß-Sitosterol was screened via PubChem and subsequently evaluated for expression in the GSE112790 dataset. In addition, the expression level of glycogen synthase kinase 3 beta (GSK3B) within the Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC) database was analyzed, along with its correlation to the survival outcomes of patients with hepatocellular carcinoma. The diagnostic efficiency of GSK3B was assessed by analyzing the ROC curve. Subsequently, Huh-7 and HCCLM3 cell lines were transfected with the overexpression vector of GSK3B and then treated with ß-Sitosterol to further validate the association between GSK3B and ß-Sitosterol. GSK3B demonstrated a significantly elevated expression in patients with hepatocellular carcinoma, which could predict hepatocellular carcinoma patients' impaired prognosis based on GEO dataset and TCGA database. GSK3B inhibitor (CHIR-98014) notably inhibited cell proliferation and invasion, promoted cell apoptosis and cell cycle arrest at G0/G1 phase in hepatocellular carcinoma cells. ß-Sitosterol treatment further promoted the efffects of GSK3B inhibitor on hepatocellular carcinoma cells. GSK3B overexpression has been found to enhance the proliferative and invasive capabilities of hepatocellular carcinoma cells. Furthermore it has been observed that GSK3B overexpression, it has been obsear can partially reverse the inhibitory effect of ß-Sitosterol upon hepatocellular. ß-Sitosterol suppressed hepatocellular carcinoma cell proliferation and invasion, and enhanced apoptosis via inhibiting GSK3B expression.


Assuntos
Apoptose , Carcinoma Hepatocelular , Proliferação de Células , Transição Epitelial-Mesenquimal , Glicogênio Sintase Quinase 3 beta , Neoplasias Hepáticas , Sitosteroides , Humanos , Sitosteroides/farmacologia , Glicogênio Sintase Quinase 3 beta/metabolismo , Glicogênio Sintase Quinase 3 beta/genética , Carcinoma Hepatocelular/patologia , Carcinoma Hepatocelular/genética , Carcinoma Hepatocelular/tratamento farmacológico , Carcinoma Hepatocelular/metabolismo , Neoplasias Hepáticas/patologia , Neoplasias Hepáticas/genética , Neoplasias Hepáticas/tratamento farmacológico , Neoplasias Hepáticas/metabolismo , Proliferação de Células/efeitos dos fármacos , Proliferação de Células/genética , Apoptose/efeitos dos fármacos , Apoptose/genética , Linhagem Celular Tumoral , Transição Epitelial-Mesenquimal/efeitos dos fármacos , Transição Epitelial-Mesenquimal/genética , Movimento Celular/efeitos dos fármacos , Movimento Celular/genética , Expressão Gênica/genética , Expressão Gênica/efeitos dos fármacos , Fenótipo , Invasividade Neoplásica/genética , Sobrevivência Celular/efeitos dos fármacos , Sobrevivência Celular/genética , Farmacologia em Rede , Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
12.
Food Res Int ; 176: 113804, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-38163683

RESUMO

To improve the stability and sustained-release property of anthocyanins (ACNs), casein (CA) - dextran (DEX) glycated conjugates (UGCA) and carboxymethyl cellulose (CMC) were used to prepare ACNs-loaded binary and ternary complexes. The ACNs-loaded binary complexes (ACNs-UGCA) and ternary complexes (ACNs-UGCA-CMC) achieved by 8 min' ultrasonic treatment with 40 % amplitude. The binary and ternary complexes showed spherical structure and good dispersibility, with the average size of 121.2 nm and 132.4 nm respectively. The anthocyanins encapsulation efficiency of ACNs-UGCA-CMC increased almost 20 % than ACNs-UGCA. ACNs-UGCA-CMC had better colloidal stabilities than ACNs-UGCA, such as thermal stability and dilution stability. Simultaneously, both of the binary and ternary complexes significantly prevented anthocyanins from being degraded by heat treatment, ascorbic acid, sucrose and simulated gastrointestinal environment. The protective effect of ACNs-UGCA-CMC was more significant. Furthermore, ACNs-UGCA-CMC showed slower anthocyanins release in simulated releasing environment in vitro and a long retention time in vivo. Our current study provides a potential delivery for improving the stability and controlling release of anthocyanins.


Assuntos
Antocianinas , Caseínas , Antocianinas/química , Carboximetilcelulose Sódica
13.
Front Neurosci ; 18: 1373515, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38765672

RESUMO

A growing number of studies apply deep neural networks (DNNs) to recordings of human electroencephalography (EEG) to identify a range of disorders. In many studies, EEG recordings are split into segments, and each segment is randomly assigned to the training or test set. As a consequence, data from individual subjects appears in both the training and the test set. Could high test-set accuracy reflect data leakage from subject-specific patterns in the data, rather than patterns that identify a disease? We address this question by testing the performance of DNN classifiers using segment-based holdout (in which segments from one subject can appear in both the training and test set), and comparing this to their performance using subject-based holdout (where all segments from one subject appear exclusively in either the training set or the test set). In two datasets (one classifying Alzheimer's disease, and the other classifying epileptic seizures), we find that performance on previously-unseen subjects is strongly overestimated when models are trained using segment-based holdout. Finally, we survey the literature and find that the majority of translational DNN-EEG studies use segment-based holdout. Most published DNN-EEG studies may dramatically overestimate their classification performance on new subjects.

14.
Heliyon ; 10(7): e28539, 2024 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-38596055

RESUMO

Left atrial (LA) fibrosis plays a vital role as a mediator in the progression of atrial fibrillation. 3D late gadolinium-enhancement (LGE) MRI has been proven effective in identifying LA fibrosis. Image analysis of 3D LA LGE involves manual segmentation of the LA wall, which is both lengthy and challenging. Automated segmentation poses challenges owing to the diverse intensities in data from various vendors, the limited contrast between LA and surrounding tissues, and the intricate anatomical structures of the LA. Current approaches relying on 3D networks are computationally intensive since 3D LGE MRIs and the networks are large. Regarding this issue, most researchers came up with two-stage methods: initially identifying the LA center using a scaled-down version of the MRIs and subsequently cropping the full-resolution MRIs around the LA center for final segmentation. We propose a lightweight transformer-based 3D architecture, Usformer, designed to precisely segment LA volume in a single stage, eliminating error propagation associated with suboptimal two-stage training. The transposed attention facilitates capturing the global context in large 3D volumes without significant computation requirements. Usformer outperforms the state-of-the-art supervised learning methods in terms of accuracy and speed. First, with the smallest Hausdorff Distance (HD) and Average Symmetric Surface Distance (ASSD), it achieved a dice score of 93.1% and 92.0% in the 2018 Atrial Segmentation Challenge and our local institutional dataset, respectively. Second, the number of parameters and computation complexity are largely reduced by 2.8x and 3.8x, respectively. Moreover, Usformer does not require a large dataset. When only 16 labeled MRI scans are used for training, Usformer achieves a 92.1% dice score in the challenge dataset. The proposed Usformer delineates the boundaries of the LA wall relatively accurately, which may assist in the clinical translation of LA LGE for planning catheter ablation of atrial fibrillation.

15.
Phys Med ; 105: 102509, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36565556

RESUMO

Liver MRI images often suffer from degraded quality due to ghosting or blurring artifacts caused by patient respiratory or bulk motion. In this study, we developed a two-stage deep learning model to reduce motion artifact on dynamic contrast enhanced (DCE) liver MRIs. The stage-I network utilized a deep residual network with a densely connected multi-resolution block (DRN-DCMB) network to remove most motion artifacts. The stage-II network applied the generative adversarial network (GAN) and perceptual loss compensation to preserve image structural features. The stage-I network served as the generator of GAN and its pretrained parameters in stage-I were further updated via backpropagation during stage-II training. The stage-I network was trained using small image patches with simulated motion artifacts including image-space rotational and translational motion, and K-space based centric and interleaved linear motion, sinusoidal, and rotational motion to mimic liver motion patterns. The stage-II network training used full-size images with the same types of simulated motion. The liver DCE-MRI image volumes without obvious motion artifacts in 10 patients were used for the training process, of which 1020 images of 8 patients were used for training and 240 images of 2 patients for validation. Finally, the whole two-stage deep learning model was tested with simulated motion images (312 clean images from 5 test patients) and patient images with real motion artifacts (28 motion images from 12 patients). The resulted images after two-stage processing demonstrated reduced motion artifacts while preserved anatomic details without image blurriness, with SSIM of 0.935 ± 0.092, MSE of 60.7 ± 9.0 × 10-3, and PSNR of 32.054 ± 2.219.


Assuntos
Artefatos , Fígado , Humanos , Fígado/diagnóstico por imagem , Abdome , Movimento (Física) , Imageamento por Ressonância Magnética/métodos , Processamento de Imagem Assistida por Computador/métodos
16.
Bioengineering (Basel) ; 10(5)2023 May 05.
Artigo em Inglês | MEDLINE | ID: mdl-37237626

RESUMO

The COVID-19 pandemic has posed unprecedented challenges to global healthcare systems, highlighting the need for accurate and timely risk prediction models that can prioritize patient care and allocate resources effectively. This study presents DeepCOVID-Fuse, a deep learning fusion model that predicts risk levels in patients with confirmed COVID-19 by combining chest radiographs (CXRs) and clinical variables. The study collected initial CXRs, clinical variables, and outcomes (i.e., mortality, intubation, hospital length of stay, Intensive care units (ICU) admission) from February to April 2020, with risk levels determined by the outcomes. The fusion model was trained on 1657 patients (Age: 58.30 ± 17.74; Female: 807) and validated on 428 patients (56.41 ± 17.03; 190) from the local healthcare system and tested on 439 patients (56.51 ± 17.78; 205) from a different holdout hospital. The performance of well-trained fusion models on full or partial modalities was compared using DeLong and McNemar tests. Results show that DeepCOVID-Fuse significantly (p < 0.05) outperformed models trained only on CXRs or clinical variables, with an accuracy of 0.658 and an area under the receiver operating characteristic curve (AUC) of 0.842. The fusion model achieves good outcome predictions even when only one of the modalities is used in testing, demonstrating its ability to learn better feature representations across different modalities during training.

17.
Food Chem ; 419: 135899, 2023 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-37023676

RESUMO

The purpose of this study is to explore the optimal conditions for the preparation of bovine serum albumin (BSA)/casein (CA)-dextran (DEX) conjugates by ultrasonic pretreatment combined with glycation (U-G treatment). When BSA and CA were treated with ultrasound (40% amplitude, 10 min), the grafting degree increased 10.57% and 6.05%, respectively. Structural analysis revealed that ultrasonic pretreatment changed the secondary structure, further affected functional properties of proteins. After U-G treatment, the solubility and thermal stability of BSA and CA was significantly increased, and the foaming and emulsifying capacity of proteins were also changed. Moreover, ultrasonic pretreatment and glycation exhibited a greater impact on BSA characterized with highly helical structure. Complexes fabricated by U-G-BSA/CA and carboxymethyl cellulose (CMC) exhibited protection on anthocyanins (ACNs), delaying the thermal degradation of ACNs. In conclusion, the protein conjugates treated by ultrasonic pretreatment combined with glycation have excellent functionality and are potential carrier materials.


Assuntos
Antocianinas , Reação de Maillard , Antocianinas/química , Estrutura Secundária de Proteína , Soroalbumina Bovina/química , Proteínas/química
18.
Int J Biol Macromol ; 253(Pt 5): 127168, 2023 Dec 31.
Artigo em Inglês | MEDLINE | ID: mdl-37783251

RESUMO

The full combination of high sensitivity indication and long-lasting bacteriostatic function is an innovative need to meet the practicality of intelligent film packaging systems for food products. Hence, Blueberry anthocyanins (BA) copigmentated by ferulic acid (FA) was used as an indicator, and cinnamon essential oil (CO) encapsulated by ß-cyclodextrin (ß-CD) as a bacteriostat, potato starch (PS) as a film-forming substrate to prepared a dual-function starch-based intelligent active packaging film with pH indicator and antibacterial function. FA had the best copigmentation effect with a threefold increase in a value compared to other phenolic acids. The ΔE value increased from 3.24 to 5.13 at pH 2-8, and the change was still prominent in acid-base alternating test, indicating a high response sensitivity. Notably, the yellow gamut of indicating terminus increased its visibility to the naked eye. The release behavior of CO from film was in line with Fick's diffusion. Meanwhile, the release of CO delayed to about 90 h through ß-cyclodextrin encapsulation, showing a high growth-inhibition rate in E. coli and S. aureus of almost 100 %. In this study, a dual-function film with indication and bacteriostasis was prepared and enhanced with both, expanding its wide application in intelligent packaging of fresh food.


Assuntos
Óleos Voláteis , beta-Ciclodextrinas , Tiram/farmacologia , Amido/farmacologia , Antocianinas/farmacologia , Escherichia coli , Staphylococcus aureus , Óleos Voláteis/farmacologia , beta-Ciclodextrinas/farmacologia , Conservação de Alimentos , Embalagem de Alimentos , Concentração de Íons de Hidrogênio
19.
J Exp Psychol Hum Percept Perform ; 48(9): 913-925, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-35849375

RESUMO

Unfamiliar accents can systematically shift speech acoustics away from community norms and reduce comprehension. Yet, limited exposure improves comprehension. This perceptual adaptation indicates that the mapping from acoustics to speech representations is dynamic, rather than fixed. But, what drives adjustments is debated. Supervised learning accounts posit that activation of an internal speech representation via disambiguating information generates predictions about patterns of speech input typically associated with the representation. When actual input mismatches predictions, the mapping is adjusted. We tested two hypotheses of this account across consonants and vowels as listeners categorized speech conveying an English-like acoustic regularity or an artificial accent. Across conditions, signal manipulations impacted which of two acoustic dimensions best conveyed category identity, and predicted which dimension would exhibit the effects of perceptual adaptation. Moreover, the strength of phonetic category activation, as estimated by categorization responses reliant on the dominant acoustic dimension, predicted the magnitude of adaptation observed across listeners. The results align with predictions of supervised learning accounts, suggesting that perceptual adaptation arises from speech category activation, corresponding predictions about the patterns of acoustic input that align with the category, and adjustments in subsequent speech perception when input mismatches these expectations. (PsycInfo Database Record (c) 2022 APA, all rights reserved).


Assuntos
Fonética , Percepção da Fala , Humanos , Idioma , Fala/fisiologia , Acústica da Fala , Percepção da Fala/fisiologia
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