Comparison of immediate vs. delayed guided tissue regeneration in Infrabony defect of second molars after adjacent third molar extraction: a retrospective study.

BACKGROUND: The distal aspect of the second molar (d-M2) often exhibits infrabony defects due to the adjacent third molar. Although the defects can be treated by guided tissue regeneration (GTR) after removing the third molar, the optimal timing remains uncertain following third molar removal in clinical decision-making. This study aimed to compare delayed and immediate GTR treatments to assist in clinical decision-making. METHODS: D-M2 infrabony defects with a minimum 1-year follow-up were collected and divided into three groups: Immediate GTR group, which underwent third molar extraction and received GTR simultaneously; Delayed GTR group, which underwent delayed GTR at least 3 months after third molar extraction; and Control group, which underwent only scaling and root planing during third molar extraction. The clinical and radiographic parameters related to the infrabony defect before GTR and post-surgery were evaluated using the Kruskal-Wallis test or one-way ANOVA, followed by post-hoc Dunn's test or the Bonferroni test for pairwise comparisons. RESULTS: A total of 109 d-M2 infrabony defects were assessed. No significant differences were found between the two GTR groups, although both of them showed significant reductions in infrabony defect depth: the immediate GTR group (2.77 ± 1.97 mm vs. 0.68 ± 1.03 mm, p < 0.001) and the delayed GTR group (2.98 ± 1.08 mm vs. 0.68 ± 1.03 mm, p < 0.001) compared to the control group. CONCLUSION: GTR can effectively improve d-M2 infrabony defects when the third molar is removed, whether simultaneously or delayed. Patients may experience less discomfort with immediate GTR treatment as it requires only one surgery.

Elucidation on inhibition and binding mechanism of bovine liver catalase by nifedipine: multispectroscopic analysis and computer simulation methods.

Nifedipine (NDP), a dihydropyridine calcium antagonist, is widely used for the treatment of hypertension and angina pectoris. Catalase is a key antioxidant enzyme that is closely relevant to the level of reactive oxygen specie in vivo. Here, the research explored the effects of NDP on the conformation and catalytic function of bovine liver catalase (BLC) through enzymatic reaction kinetic techniques, multispectroscopic analysis, and computer simulation methods. Kinetic studies clarified that the NDP reduced the activity of BLC using a noncompetitive inhibition mechanism. Based on trial data, a static quenching mechanism functioned in quenching the intrinsic fluorescence of BLC. The binding constant value was (4.486 ± 0.008) × 104 M-1 (298 K) and BLC had one binding site for NDP. Tyr was prone to be exposed more to a hydrophilic environment in wake of a shift in fluorescence value. The binding reaction of BLC to NDP caused a conformational change in BLC, which in turn led to increase in the α-helix content and a decline in the ß-sheet content. Furthermore, several amino acids residues interacted with NDP by means of van der Waals forces, whereas Gln397, Asn368, Gln371, Asn384, and Pro377 formed several hydrogen bonds with NDP.

Cementodentinal Tear Associated with a Periodontal- Endodontic Combined Lesion: A Case Report with a 14-Month Follow-up.

This case report describes the diagnosis and multidisciplinary treatment of a clinically indiscoverable cementodentinal tear associated with a periodontal-endodontic combined lesion. The tear site was located at the palatal root surface of the maxillary left canine. Due to its position and concomitant periapical periodontitis, it was not noticed at the initial visit until a 3D CBCT examination was conducted. Through combined endodontic-periodontal therapy (which included root canal therapy, root debridement, and periodontal flap surgery), the tear fragment was removed, and the periapical lesion healed gradually. A histologic examination confirmed the definitive diagnosis of a cementodentinal tear. After 14 months, the periodontal and endodontic status of the maxillary left canine were stable. According to these results, CBCT examination and multidisciplinary cooperation seem to be effective and necessary for the diagnosis and treatment of such clinically indiscoverable cementodentinal/cemental tears.

Examining athlete mental health and postoperative recurrence in chronic sinusitis with nasal polyps: an analysis of clinical treatment strategie

Objective: This study aims to investigate the intersection of athlete mental health and postoperative recurrence in athletes patients with chronic sinusitis and nasal polyps (CRSwNP), focusing on the analysis of clinical treatment strategies. Methods: A cohort of 400 athletes diagnosed with CRSwNP, who underwent nasal endoscopic surgery at our hospital between March 2021 and March 2022, was included in this investigation. Retrospective analysis of clinical treatment data was conducted. Athletes Patients were categorized into the recurrent group (n=136) and the non-recurrent group (n=264). Univariate analysis was applied to identify factors influencing postoperative recurrence among CRSwNP patients. Subsequently, multivariate logistic regression analysis was carried out to determine the independent risk factors. Based on these findings, clinical treatment strategies were devised to address athlete mental health and enhance patient outcomes. Results: The study revealed a postoperative recurrence rate of 34.0% in CRSwNP patients. Athletes Patients in the recurrent group exhibited a longer disease duration compared to their non-recurrent counterparts. Notably, the recurrent group displayed significantly higher proportions of eosinophil (EOS) infiltration in nasal polyps, bronchial asthma, allergic rhinitis, peripheral blood EOS > 5.3%, and peripheral blood neutrophils (Neu) > 55.5% than the non-recurrent group (P<0.05). Conversely, the proportion of tissue lymphocytes < 30% was lower in the recurrent group. Furthermore, scores for anterior ethmoids (AE), posterior ethmoids (PE), ostiomeatal complex (OMC), and total scores in the recurrent group were significantly elevated compared to the non-recurrent group, with statistically significant differences (P<0.05). (AU)