1.
IUCrJ
; 4(Pt 5): 560-568, 2017 Sep 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28989713
RESUMO
Single-particle imaging with X-ray free-electron lasers (XFELs) has the potential to provide structural information at atomic resolution for non-crystalline biomolecules. This potential exists because ultra-short intense pulses can produce interpretable diffraction data notwithstanding radiation damage. This paper explores the impact of pulse duration on the interpretability of diffraction data using comprehensive and realistic simulations of an imaging experiment at the European X-ray Free-Electron Laser. It is found that the optimal pulse duration for molecules with a few thousand atoms at 5â keV lies between 3 and 9â fs.