Prevalence of endocrine disorders and their associated factors in transfusion-dependent thalassemia patients: a historical cohort study in Southern Iran.

PURPOSE: Transfusion-dependent beta-thalassemia (TDT) patients suffer from various endocrinopathies. The main contributing factor associated with these complications is iron overload, secondary to frequent blood transfusions. To improve patients' quality of life, we evaluated the prevalence of endocrine disorders while considering the associated factors for further assessment. METHODS: Seven hundred thirteen transfusion-dependent thalassemia patients with age range 10-62 years were enrolled in this study. Serum calcium, phosphorous, fast blood sugar, ferritin, 25-OH vitamin D, free thyroxin, thyroid-stimulating hormone and parathyroid hormone were assessed. Bone mineral density was measured by dual-energy X-ray absorptiometry. RESULTS: In total, 86.8% of the TDT patients suffered from at least one endocrinopathy. The prevalence of endocrinopathies in descending order of frequency was low bone mass (72.6%), hypogonadism (44.5%), diabetes mellitus (15.9%), hypoparathyroidism (13.2%), and hypothyroidism (10.7%). Age, body mass index and splenectomy were significantly associated with most of the endocrine disorders. CONCLUSION: Endocrine complications are frequently observed in TDT patients. Splenectomy is a major risk factor and should be generally avoided unless it is highly indicated. Periodic surveillance of endocrine function and proper management of iron overload are advised.

Obesity and overweight among primary school children in Iran.

AIM: The aim of this paper was to describe the prevalence of overweight (preobesity and obesity) among 7- to 13-year-old children in different parts of Jahrom City, Southern Iran, during 2008-2009. METHODS: A total of 1158 students (587 males and 571 females) aged 7-13 years were assessed over a period of 12 months. Schools were randomly selected in each district of the city, and the participating children were selected using stratified randomization for age, with the aid of a table of random numbers. Body Mass Index (BMI) was measured for each subject. We adopted the 5th, 85th and 95th percentiles of the CDC as cut-off points for thin, overweight and obese children, respectively, as generally accepted. RESULTS: Age of the children ranged from 7 to 13 years with a mean of 9.9 ± 1.6 years. A total of 58 boys (9.9%) and 57 girls (10%) were overweight, and the difference between them was not statistically significant. However, obesity was less prevalent among girls (4.9%) compared to boys (5.1%). CONCLUSION: In this survey, prevalence of obesity among girls and boys was 4.9% and 5.1%, respectively. The scope of prevalence of obesity is remarkable enough for a mid-size semi-industrialized society in comparison with heavy industrialized parts of Iran, thus there is an urgent need to target younger ages for prevention and implementation of public educational programs to curtail this rising trend of obesity in young men and women.