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1.
J Am Acad Dermatol ; 81(2): 480-488, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30954583

RESUMO

BACKGROUND: Exposure to the sun causes premature skin aging, known as photoaging. Clinical features of photoaging vary widely among individuals. In one form, skin appears thin with telangiectasia, and in another form, skin appears thickened with coarse wrinkles. Etiologic, clinical, and therapeutic distinctions among different forms of photoaging remain largely unknown. OBJECTIVE: To characterize the clinical, histologic, and molecular features of hypertrophic and atrophic photoaging. METHODS: In total, 53 individuals were clinically classified as having primarily atrophic or hypertrophic photoaging or neither (controls). Participants' demographic and sun exposure-related lifestyle data were captured by questionnaire. Fifteen clinical features of participants were qualitatively or quantitively scored. Facial biopsies were analyzed for gene expression and histologic characteristics. RESULTS: Actinic and seborrheic keratosis, telangiectasia, and prior incidence of skin cancers were statistically significantly greater and photoaging scale severity, coarse wrinkles, thickness, and sallowness were significantly reduced in atrophic versus hypertrophic groups. Histology also revealed significantly less elastotic material in atrophic photoaging. Gene expression of matrix metalloproteinases and collagens did not differ between the 2 forms of photoaging. LIMITATIONS: The study was not designed to identify other possible subtypes of photoaging. CONCLUSION: Systematic, categorical, and quantitative clinical and histologic assessments distinguish atrophic and hypertrophic photoaging.


Assuntos
Carcinoma Basocelular/epidemiologia , Carcinoma de Células Escamosas/epidemiologia , Envelhecimento da Pele/genética , Envelhecimento da Pele/patologia , Neoplasias Cutâneas/epidemiologia , Pele/metabolismo , Pele/patologia , Idoso , Idoso de 80 Anos ou mais , Atrofia/genética , Atrofia/patologia , Biópsia , Colágeno/genética , Face , Feminino , Expressão Gênica , Humanos , Hipertrofia/genética , Hipertrofia/patologia , Incidência , Ceratose Actínica/epidemiologia , Ceratose Seborreica/epidemiologia , Estilo de Vida , Masculino , Metaloproteinases da Matriz/genética , Pessoa de Meia-Idade , Fenótipo , Pele/efeitos da radiação , Envelhecimento da Pele/efeitos da radiação , Inquéritos e Questionários , Telangiectasia/epidemiologia , Telangiectasia/patologia , Raios Ultravioleta/efeitos adversos
2.
J Eur Acad Dermatol Venereol ; 29(1): 134-42, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-24684198

RESUMO

BACKGROUND: There is a perpetuating increase in melanoma and basal cell carcinoma (BCC) incidence in Europe. Few studies are evaluating various risk factors for both tumours. OBJECTIVES: This pre-planned additional analysis directly compared occupational and past-time ultraviolet exposure behaviour, and examined the effects of sun sensitivity between melanoma and sporadic BCC, and assessed its importance for the two entities. PATIENTS/METHODS: The study included 503 patients (melanoma, n = 291 and BCC, n = 212), and 329 controls from Germany. In all, 244 (49%) of the cases and 165 (50%) of the controls were male (median age melanoma, 55 years; BCC, 69 years; and controls, 57 years). Selection of important risk factors was performed by backward elimination in a polytomous logistic regression. RESULTS: When directly comparing melanoma and sporadic BCC, actinic elastosis (OR 48.83; 95% CI 17.87, 133.40) and site were associated with a higher risk of melanoma, whereas mountaineering in childhood, sunburn 20 years before diagnosis, farming full time, sunbed use in general, seborrheic keratosis, actinic cheilitis, actinic keratosis and age were associated with a higher risk of sporadic BCC. Gardening 20 years before melanoma, hair colour and solar lentigo were risk factors for both entities. A re-evaluation of the data excluding lentiginous melanoma entities (i.e. acro-lentiginous and lentigo-maligna melanoma) resulted in selection of the same factors. However, compared to controls, atopy evolved as a protective factor for melanoma (OR 0.29; 95% CI 0.15, 0.57) and BCC (OR 0.41; 95% CI 0.17, 0.99), respectively, but was associated with a higher risk of sporadic BCC compared to melanoma. CONCLUSION: The odds for having clinical actinic elastosis was lower in BCC compared to melanoma. In contrast, various factors associated with chronic UV exposure and age had higher odds for sporadic BCC, rather than melanoma. Further research is required to set the context for these findings, especially regarding, atopy in non-lentiginous vs. lentiginous forms of melanoma, and possible molecular pathways involved.


Assuntos
Carcinoma Basocelular/epidemiologia , Melanoma/epidemiologia , Exposição Ocupacional/efeitos adversos , Recreação , Neoplasias Cutâneas/epidemiologia , Raios Ultravioleta/efeitos adversos , Fatores Etários , Idoso , Agricultura , Carcinoma Basocelular/etiologia , Queilite/epidemiologia , Criança , Feminino , Jardinagem , Alemanha/epidemiologia , Humanos , Ceratose Actínica/epidemiologia , Ceratose Seborreica/epidemiologia , Masculino , Melanoma/etiologia , Pessoa de Meia-Idade , Montanhismo , Fatores de Risco , Neoplasias Cutâneas/etiologia , Queimadura Solar/epidemiologia
3.
J Drugs Dermatol ; 14(10): 1119-25, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26461823

RESUMO

Seborrheic keratosis (SK) is among the most common cutaneous lesions, affecting some 83 million Americans. Biologically benign, SK lesions do not require removal for medical reasons unless histologic confirmation of the clinical diagnosis is required or the lesions are traumatized and/or become symptomatic. These macular or popular pigmented lesions are often of cosmetic concern to patients. In addition, their natural history of gradually increasing in size, thickness, and/or pigmentation often serves as the impetus compelling patients to present to a dermatologist for evaluation and skin cancer screening; SK is diagnosed and managed primarily by dermatologists. Data regarding SK prevalence and management from a survey of 594 practicing, board-certified dermatologists are summarized herein: Dermatologists report they diagnose an average of 155 patients per month with SK. Among SK patients presenting to dermatologists, 33% have more than 15 SK lesions and 67% have 15 or fewer SK lesions. On average, dermatologists treat 43% of their SK patients to remove lesions. Cryosurgery is the most common removal method. Other commonly employed removal methods include shave excision, electrodessication, curettage or a combination of these. While these procedures can be used to remove SK lesions effectively, each has potential drawbacks and careful patient selection is required to optimize cosmetic results particularly in skin of color patients and patients with thick or numerous lesions. While there is great interest from both patients and providers in a topical non-invasive treatment for SK, no effective topical therapeutic agent has been developed, and this remains an area of unmet need.


Assuntos
Dermatologia/métodos , Ceratose Seborreica/patologia , Seleção de Pacientes , Criocirurgia/métodos , Curetagem/métodos , Humanos , Ceratose Seborreica/diagnóstico , Ceratose Seborreica/epidemiologia , Prevalência , Estados Unidos/epidemiologia
4.
Acta Derm Venereol ; 94(6): 683-6, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-24573000

RESUMO

The increasing incidence of melanoma prompts a need for efficient management of this patient group. In this study, we use the number needed to excise (NNE), as a measurement of the efficiency of diagnosing melanoma. From January 2009 to December 2012, postoperative records from all patients were prospectively registered. All excised tumours with the histopathological diagnosis of naevus, melanoma or seborrhoeic keratosis were included. NNE values, both excluding and including seborrhoeic keratosis, changes over time, as well as patient- and tumour-related factors influencing NNE were determined. In total, 1,717 cases were included. The overall NNE value was 6.5, and the value fell significantly (r = 0.959, p = 0.041) during the 4-year study period from 8.2 to 4.8. NNE values decreased with increasing patient age to 1.8 in patients ≥ 80 years of age. The overall NNE value including seborrhoeic keratosis was 6.8.


Assuntos
Dermatologia/métodos , Ceratose Seborreica/diagnóstico , Ceratose Seborreica/cirurgia , Melanoma/diagnóstico , Melanoma/cirurgia , Nevo Pigmentado/diagnóstico , Nevo Pigmentado/cirurgia , Números Necessários para Tratar , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Detecção Precoce de Câncer , Eficiência , Feminino , Humanos , Incidência , Ceratose Seborreica/epidemiologia , Masculino , Melanoma/epidemiologia , Pessoa de Meia-Idade , Nevo Pigmentado/epidemiologia , Valor Preditivo dos Testes , Estudos Prospectivos , Sistema de Registros , Neoplasias Cutâneas/epidemiologia , Suécia/epidemiologia , Fatores de Tempo , Procedimentos Desnecessários
5.
G Ital Dermatol Venereol ; 149(2): 161-6, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24819635

RESUMO

AIM: Accuracy in melanoma detection is important to recognize early curable melanomas and to minimize the unnecessary excision of benign lesions. The aim of this paper was to evaluate melanoma screening accuracy of Italian pigmented lesion clinics in terms of number needed to excise (NNE), melanoma thickness, and number of melanomas diagnosed during patient follow-up. METHODS: Information on all skin tumors excised in 2011 were extracted from the databases of the participating centers. Information whether the lesion was excised at the baseline examination or during patient follow-up was recorded, as well as the overall number of patients examined in each center in 2011. RESULTS: After e-mail solicitation, 22 of 40 centers agreed to participate. A total of 8229 excised lesions were collected. The overall number of examined patients was 86.564, thus 9.5% of screened patients had a lesion removed. Of the excised lesions, 866 were diagnosed as melanoma (1% of examined patients) and 5311 (88.9%) were melanocytic nevi. Three NNE were calculated giving values of 7.9 excised lesions to find 1 melanoma, 7.1 melanocytic lesions to find 1 melanoma, and 3.7 lesions to find 1 skin malignancy. The median melanoma thickness was 0.6 mm, with only 15.1% of melanomas ≥ 1 mm of thickness. Melanomas detected over time were 96 (11.1%; mean thickness, 0.3 mm), with 15.6% of lesions excised after short-term follow-up and 84.4% after long-term follow-up. CONCLUSION: The NNE values comparable to those achieved in specialized clinical settings and the high number of early melanomas diagnosed at the baseline examination or during patient follow-up indicate a high level of accuracy in melanoma screening achieved by Italian pigmented lesion clinics.


Assuntos
Instituições de Assistência Ambulatorial/estatística & dados numéricos , Dermatologia/organização & administração , Melanoma/diagnóstico , Nevo Pigmentado/diagnóstico , Neoplasias Cutâneas/diagnóstico , Adolescente , Adulto , Idoso , Carcinoma Basocelular/diagnóstico , Carcinoma Basocelular/epidemiologia , Carcinoma Basocelular/cirurgia , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/epidemiologia , Carcinoma de Células Escamosas/cirurgia , Dermoscopia , Detecção Precoce de Câncer , Feminino , Seguimentos , Humanos , Itália/epidemiologia , Ceratose Seborreica/diagnóstico , Ceratose Seborreica/epidemiologia , Ceratose Seborreica/cirurgia , Masculino , Melanoma/epidemiologia , Melanoma/patologia , Melanoma/cirurgia , Pessoa de Meia-Idade , Gradação de Tumores , Nevo Pigmentado/epidemiologia , Nevo Pigmentado/patologia , Nevo Pigmentado/cirurgia , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/cirurgia , Adulto Jovem
6.
Sci Rep ; 14(1): 5223, 2024 03 04.
Artigo em Inglês | MEDLINE | ID: mdl-38433172

RESUMO

Seborrheic keratosis (SK) is a common skin disease in the elderly. However, in cases where SK presenting as multiple skin-colored or clustered lesions can be easily misdiagnosed as verruca plana (VP), especially in the young population. This retrospective study investigated the prevalence of SK and VP in the lesions that appear clinically similar to VP according to age. We examined the pathology slides of the skin tissue and photographs of patients who were clinically suspected to have VP. A total of 503 patients were included in the study, out of which 174 patients were finally diagnosed with SK (34.6%) and 132 with VP (26.2%). The mean ages of the SK- and VP-diagnosed group were 39.3 and 35.4 years, respectively. SK had a higher prevalence among individuals older than 30 years, and relative frequency of SK should not be ignored in patients with a grouped distribution in their 20 s and 30 s. Therefore, our study suggests that multiple verrucous skin-colored to brownish plaques are also commonly diagnosed as SK in young people as well as VP, and the prevalence of SK and VP may not always depend solely on chronological aging, and the prevalence of SK among young people may be higher than commonly believed stereotypes suggest.


Assuntos
Ceratose Seborreica , Verrugas , Idoso , Humanos , Adolescente , Ceratose Seborreica/epidemiologia , Incidência , Estudos Retrospectivos , Pele , Verrugas/epidemiologia
7.
JAMA Dermatol ; 159(12): 1368-1372, 2023 12 01.
Artigo em Inglês | MEDLINE | ID: mdl-37938822

RESUMO

Importance: Actinic keratoses (AK) are common premalignant skin lesions with a small risk of progressing to cutaneous squamous cell carcinoma (SCC). There is some evidence that patients with AKs also have increased risks of other skin cancers beyond SCC. However, the absolute risks of skin cancer in patients with AKs are unknown. Objective: To calculate the absolute and relative risks of future skin cancer in Medicare beneficiaries with AKs. Design, Setting, and Participants: This retrospective cohort study was performed using a deidentified, random sample of 4 999 999 fee-for-service Medicare beneficiaries from 2009 through 2018. Patients with treated AKs were included, and patients with seborrheic keratoses (SKs) were included as a comparator group. All patients were required to have at least 1 year between data set entry and first AK or SK. Patients with a history of skin cancer were excluded. Data were analyzed from September 2022 to March 2023. Main Outcomes and Measures: Outcomes were first surgically treated skin cancer, including keratinocyte carcinoma (including SCC and basal cell carcinoma [BCC]) and melanoma. The absolute risks of skin cancer in patients with AKs were evaluated. Skin cancer risks in patients with AKs were compared with patients with SKs using adjusted competing risks regression. Results: A total of 555 945 patients with AKs (mean [SD] age, 74.0 [7.4] years; 55.4% female) and 481 024 patients with SKs (mean [SD] age, 73.3 [7.3] years; 72.4% female) were included. The absolute risk of skin cancer after a first AK was 6.3% (95% CI, 6.3%-6.4%) at 1 year, 18.4% (95% CI, 18.3%-18.5%) at 3 years, and 28.5% (95% CI, 28.4%-28.7%) at 5 years. Patients with AKs had increased risk of skin cancer compared with patients with SKs (any skin cancer: adjusted hazard ratio [aHR], 2.17; 95% CI, 2.15-2.19; keratinocyte carcinoma: aHR, 2.20; 95% CI, 2.18-2.22; SCC: aHR, 2.63; 95% CI, 2.59-2.66; BCC: aHR, 1.85; 95% CI, 1.82-1.87; and melanoma: aHR, 1.67; 95% CI, 1.60-1.73). Conclusions and Relevance: In this cohort study, older patients with AKs had substantial absolute risks, as well as elevated relative risks, of skin cancer. AKs may be clinical markers of UV exposure and increased skin cancer risk, including SCC, BCC, and melanoma. However, guidelines are lacking for follow-up skin cancer surveillance in patients with AKs. Efforts to develop evidence-based recommendations for skin cancer surveillance in patients with AKs are paramount.


Assuntos
Carcinoma Basocelular , Carcinoma de Células Escamosas , Ceratose Actínica , Ceratose Seborreica , Melanoma , Neoplasias Cutâneas , Humanos , Feminino , Idoso , Estados Unidos/epidemiologia , Masculino , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/etiologia , Neoplasias Cutâneas/patologia , Ceratose Actínica/epidemiologia , Ceratose Actínica/patologia , Carcinoma de Células Escamosas/epidemiologia , Melanoma/epidemiologia , Estudos de Coortes , Estudos Retrospectivos , Medicare , Carcinoma Basocelular/epidemiologia , Ceratose Seborreica/epidemiologia
8.
J Am Acad Dermatol ; 67(2): 194.e1-8, 2012 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-22030020

RESUMO

BACKGROUND: Crystalline/chrysalis structures (CS) are white shiny streaks that can only be seen with polarized dermatoscopy. OBJECTIVES: We sought to estimate the prevalence and assess the clinical significance of CS in melanocytic and nonmelanocytic lesions. METHODS: This was a prospective observational study in which dermatoscopic assessment of lesions was recorded in consecutive patients examined during a 6-month period. In addition, a data set of biopsy-proven melanomas was retrospectively analyzed. RESULTS: In all, 11,225 lesions in 881 patients were prospectively examined. Retrospectively, 229 melanomas imaged with polarized dermatoscopy were analyzed. In the prospective data set, a median of 12.7 lesions (range, 1-54) were evaluated per patient. None of clinically diagnosed Clark nevi (n = 9750, 86.8%) demonstrated CS. Overall, CS were observed in 206 (1.8%) lesions, most commonly dermatofibromas and scars among nonbiopsied lesions. A total of 265 (2.4%) lesions were biopsied, including 20 melanomas and 36 nevi. Among biopsied malignant lesions, CS were most commonly observed in basal cell carcinoma (47.6%) and invasive melanomas (84.6%). Melanomas were more likely to have CS than biopsied nevi (odds ratio = 9.7, 95% confidence interval 2.7-34.1). In the retrospective data set, CS were more commonly observed among invasive melanomas (41%) compared with in situ melanomas (17%) (odds ratio = 3.4, 95% confidence interval 1.9-6.3, P < .001). The prevalence of CS correlated with increased melanoma thickness (P = .001). LIMITATIONS: Biopsied lesions represent a small percentage of the total number of lesions evaluated. CONCLUSION: Among biopsied malignant lesions, CS are most commonly observed in basal cell carcinoma and invasive melanomas and rarely seen in nevi. In melanoma, CS may reflect increased tumor thickness and progression.


Assuntos
Carcinoma Basocelular/patologia , Histiocitoma Fibroso Benigno/patologia , Ceratose Seborreica/patologia , Melanoma/patologia , Nevo Pigmentado/patologia , Neoplasias Cutâneas/patologia , Carcinoma in Situ/epidemiologia , Carcinoma in Situ/patologia , Carcinoma Basocelular/epidemiologia , Cristalização , Dermoscopia , Histiocitoma Fibroso Benigno/epidemiologia , Humanos , Ceratose Seborreica/epidemiologia , Melanoma/epidemiologia , Invasividade Neoplásica/patologia , Nevo Pigmentado/epidemiologia , Prevalência , Estudos Prospectivos , Estudos Retrospectivos , Pele/química , Pele/patologia , Neoplasias Cutâneas/epidemiologia
9.
Dermatol Online J ; 16(1): 1, 2010 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-20137743

RESUMO

The term "melanocytic nevus" comprises a group of clinically and pathologically distinct subtypes. In this prospective clinical study we evaluated the frequency, localization, and age and gender distribution of flat nevi (FN), Miescher nevi (MN), and Unna nevi (UN) in a caucasian population. Nevi were counted in 400 patients, of which 47 had a history of melanoma. Additionally, the patients answered to a detailed UV questionnaire. Flat nevi represented the most common type of melanocytic nevi, with a peak in the 3rd decade of life. They were mostly found on the extremities and on the trunk. Miescher nevi were most common in the 6th decade and were predominantly found in the head and neck region. Unna nevi showed a maximum in the 8th decade and they were mainly situated on the trunk. The counts of all three nevus subtypes were elevated in the melanoma group. Our results confirm that FN, MN, and UN represent melanocytic nevi with distinctive morphological and clinical characteristics. The role of sunlight seems to be more prominent in the pathogenesis of FN. The precise description of FN, MN, and UN may serve as a base for a pathogenetic distinction of subtypes of melanocytic nevi in the future.


Assuntos
Nevo Pigmentado/classificação , Neoplasias Cutâneas/classificação , Adolescente , Adulto , Idade de Início , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Neoplasias Faciais/epidemiologia , Feminino , Humanos , Ceratose Seborreica/epidemiologia , Lentigo/epidemiologia , Masculino , Pessoa de Meia-Idade , Neoplasias Primárias Múltiplas/epidemiologia , Neoplasias Primárias Múltiplas/patologia , Nevo Pigmentado/epidemiologia , Nevo Pigmentado/patologia , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/patologia , Luz Solar/efeitos adversos , Adulto Jovem
11.
Stomatologiia (Mosk) ; 88(5): 45-8, 2009.
Artigo em Russo | MEDLINE | ID: mdl-20037539

RESUMO

Clinical resuls of examination of 280 oncologic patients 51-60 are presented. The aim was to detect seborrheal keratosis of face and neck in these patients. 280 patient of given age group of maxillo-facial department were controls. Two fold increase in the presence of seborrheal keratosis of face and neck in oncologic patients was found as compared to control group.


Assuntos
Dermatoses Faciais/epidemiologia , Ceratose Seborreica/epidemiologia , Pescoço , Neoplasias/complicações , Fatores Etários , Dermatoses Faciais/patologia , Feminino , Humanos , Ceratose Seborreica/patologia , Masculino , Pessoa de Meia-Idade , Pescoço/patologia , Fatores Sexuais , Pele/patologia
12.
Clin Dermatol ; 37(5): 487-506, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31896404

RESUMO

Brown diseases comprise disorders leading to hyperpigmentation in skin and nails. Melasma is an acquired skin disorder that is characterized by brownish macules that typically occur on the face. Schamberg disease, also known as progressive pigmented purpura, is characterized by brown pigmentation with pepper spots on their edges. We summarize the epidemiology, pathogenesis, histologic features, and treatment choices for additional brown diseases, including melasma, pigmented purpuric dermatoses, postinflammatory hyperpigmentation, drug-induced hyperpigmentation, and pigmentations due to systemic or physiologic conditions.


Assuntos
Doenças da Unha/etiologia , Doenças da Unha/terapia , Transtornos da Pigmentação/etiologia , Transtornos da Pigmentação/terapia , Doença de Addison/complicações , Doença de Addison/diagnóstico , Cor , Síndrome de Cushing/complicações , Síndrome de Cushing/diagnóstico , Humanos , Inflamação/complicações , Ceratose Seborreica/epidemiologia , Ceratose Seborreica/etiologia , Ceratose Seborreica/terapia , Melanose/epidemiologia , Melanose/etiologia , Melanose/terapia , Mucosa , Doenças da Unha/diagnóstico , Transtornos da Pigmentação/diagnóstico , Transtornos da Pigmentação/epidemiologia , Púrpura/epidemiologia , Púrpura/etiologia , Úlcera Varicosa/diagnóstico , Úlcera Varicosa/etiologia
14.
Am J Clin Dermatol ; 18(5): 681-685, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28397109

RESUMO

BACKGROUND: Screening of skin cancer by teledermatology (TD) has improved the early detection of skin cancer by enhancing access to skin cancer clinics. OBJECTIVE: We sought to analyze how TD-based skin cancer screening has changed the frequency of consultations for benign lesions. PATIENTS AND METHODS: A cross-sectional study including teleconsultations received during a 7-year period was conducted to analyze and compare the trendlines of each lesion type over the study period. Trendlines were analyzed using a linear regression model with the R-squared (R 2) test for goodness of fit. RESULTS: A total of 34,553 teleconsultations were included in the study. Seborrheic keratoses, followed by benign melanocytic lesions, were the most frequent lesions diagnosed. The pick-up rate for malignant lesions was 1:8.6 teleconsultations. Seborrheic keratoses and precancerous lesions showed a positive trendline with good fit to the linear model (R 2 = 0.8 and R 2 = 0.8, respectively). Tis-T1 malignant melanoma (in situ melanoma or melanoma with a Breslow thickness <1 mm) showed an increasing trendline with moderate-to-low fit to the model (R 2 = 0.4). CONCLUSIONS: TD-based screening of skin cancer is associated with an increasing rate of consultations involving seborrheic keratoses, which can be considered a consequence of improved access to dermatologists resulting from TD implementation.


Assuntos
Dermatologia/métodos , Ceratose Seborreica/diagnóstico , Melanoma/diagnóstico , Neoplasias Cutâneas/diagnóstico , Telemedicina/métodos , Estudos Transversais , Dermatologia/tendências , Diagnóstico Diferencial , Detecção Precoce de Câncer/métodos , Detecção Precoce de Câncer/tendências , Acessibilidade aos Serviços de Saúde/estatística & dados numéricos , Acessibilidade aos Serviços de Saúde/tendências , Humanos , Ceratose Seborreica/epidemiologia , Programas de Rastreamento/métodos , Programas de Rastreamento/tendências , Melanoma/epidemiologia , Encaminhamento e Consulta/estatística & dados numéricos , Encaminhamento e Consulta/tendências , Neoplasias Cutâneas/epidemiologia , Espanha/epidemiologia , Telemedicina/tendências , Melanoma Maligno Cutâneo
15.
Niger Postgrad Med J ; 13(4): 354-6, 2006 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-17203131

RESUMO

OBJECTIVE: A histopathologic analysis of epidermal skin tumours and tumour-like lesions seen between 1991 - 2000 in the Department of Pathology, Ahmadu Bello University Teaching Hospital [A.B.U.T.H], Zaria is presented. PATIENTS AND METHOD: These tumours were classified according to World Health Organisation's International Histological Classification for Skin Tumours and were tabulated. RESULTS: A total of 350 such lesions comprising 9.9% of all cutaneous neoplasms seen within the study period were collected. Overall, they have a male to female ratio of 1.7:1. Malignant tumours constituted 72.5%; benign tumours 18.3% and tumour-like lesions 9.2%. The commonest malignant lesion was squamous cell carcinoma, which constituted 68.3% of all the lesions with a male to female ratio of 1.7:1. Epidermal cyst comprised 16.3% with a male to female ratio of 1.5:1. CONCLUSION: It is concluded that epidermal tumours and tumour-like lesions are not uncommon in Zaria and they show a male preponderance with squamous cell carcinoma being the commonest epidermal tumour and it also predominantly affects males.


Assuntos
Dermatopatias/epidemiologia , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/patologia , Distribuição por Idade , Carcinoma Basocelular/epidemiologia , Carcinoma de Células Escamosas/epidemiologia , Cisto Epidérmico/epidemiologia , Feminino , Hospitais de Ensino , Humanos , Ceratoacantoma/epidemiologia , Ceratose Seborreica/epidemiologia , Masculino , Nigéria/epidemiologia , Estudos Retrospectivos , Dermatopatias/patologia
16.
J Invest Dermatol ; 123(2): 388-94, 2004 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-15245440

RESUMO

Genomes of human papillomaviruses (HPV) are common in biopsies from non-melanoma skin cancers but are also found on healthy skin and it is possible that HPV positivity in tumor biopsies by PCR may merely reflect contamination of the lesion surface. To investigate this issue, 229 immunocompetent patients were tested for HPV DNA in swab samples collected on top of skin tumors and in biopsies of the same tumors, obtained after stripping with tape to remove superficial layers. HPV DNA was detected on top of 69% (159 of 229) of the lesions, and in 12% (28 of 229) of the stripped biopsies (p<0.001). The difference was seen for all four types of tumors studied. Seborrheic keratosis had 79% (34 of 43) HPV positivity on top of lesions versus 19% (eight of 43) in biopsies; actinic keratosis had 83% (38 of 46) HPV positivity on top versus 11% (five of 46) in biopsies; basal cell carcinoma had 63% (69 of 109) on top versus 8% (nine of 109) in biopsies and squamous cell carcinoma had 58% (18 of 31) on top versus 19% (six of 31) in biopsies. HPV DNA is common in superficial layers of lesions, but is not necessarily present throughout tumors.


Assuntos
Carcinoma de Células Escamosas/patologia , Papillomaviridae/isolamento & purificação , Infecções por Papillomavirus/patologia , Neoplasias Cutâneas/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Biópsia , Carcinoma Basocelular/epidemiologia , Carcinoma Basocelular/patologia , Carcinoma Basocelular/virologia , Carcinoma de Células Escamosas/epidemiologia , Carcinoma de Células Escamosas/virologia , DNA Viral/análise , Feminino , Humanos , Ceratose Seborreica/epidemiologia , Ceratose Seborreica/patologia , Ceratose Seborreica/virologia , Masculino , Pessoa de Meia-Idade , Papillomaviridae/genética , Infecções por Papillomavirus/epidemiologia , Prevalência , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/virologia
17.
J Dermatol Sci ; 16(1): 74-8, 1997 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-9438911

RESUMO

We determined the incidence of actinic keratosis (AK) among Japanese by screening for skin cancer in Kasai City, Hyogo, Japan, between 1993 and 1995. The incidence per 100,000 Japanese residents was 223.6 in 1993 and 171.2 in 1994. The prevalence of AK was 291.2 per 100,000 residents in 1993, 203.7 in 1994, and 86.8 in 1995. The prevalence in people who had more than six seborrheic keratoses on sun-exposed body sites and in people who had experienced severe sunburns with blister formation during childhood were significantly higher. These results indicate that more than six seborrheic keratoses and several episodes of blister formation in childhood may be risk factors for AK in the Japanese.


Assuntos
Ceratose/epidemiologia , Transtornos de Fotossensibilidade/epidemiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Vesícula/complicações , Feminino , Humanos , Incidência , Japão/epidemiologia , Ceratose/etiologia , Ceratose Seborreica/epidemiologia , Ceratose Seborreica/etiologia , Masculino , Pessoa de Meia-Idade , Transtornos de Fotossensibilidade/etiologia , Prevalência , Queimadura Solar/complicações , Luz Solar/efeitos adversos
18.
Arch Dermatol ; 138(12): 1562-6, 2002 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-12472343

RESUMO

OBJECTIVE: To estimate the prevalence of melanoma clinically mimicking seborrheic keratosis. DESIGN: Retrospective review of cases submitted for histological examination with a clinical diagnosis of seborrheic keratosis or with a differential diagnosis that included seborrheic keratosis. SETTING: A tertiary medical care center-based dermatopathology laboratory serving academic dermatology clinics that have a busy pigmented lesion clinic. MATERIALS AND METHODS: A total of 9204 consecutive pathology reports containing a diagnosis of seborrheic keratosis in the clinical information field were identified between the years 1992 and 2001 through a computer database search. Reports with a final histological diagnosis of melanoma were selected for further review and clinicopathological analysis. MAIN OUTCOME MEASURE: Histological diagnosis, which was correlated with the preoperative clinical diagnosis. RESULTS: Melanoma was identified in 61 cases (0.66%) submitted for histological examination with a clinical diagnosis that included seborrheic keratosis. Melanoma was in the clinical differential diagnosis of 31 cases (51%). The remaining lesions had a differential diagnosis of seborrheic keratosis vs melanocytic nevus (17 cases, 28%), basal cell carcinoma (7 cases, 12%), or a squamous proliferation (3 cases, 5%). In 3 cases (5%), seborrheic keratosis was the only clinical diagnosis. All histological types of melanoma were represented. CONCLUSIONS: Our results confirm that melanoma can mimic seborrheic keratosis. These data strongly support the current policy of submitting for histological examination all specimens that have been removed from patients.


Assuntos
Ceratose Seborreica/epidemiologia , Ceratose Seborreica/patologia , Melanoma/epidemiologia , Melanoma/patologia , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/patologia , Adulto , Distribuição por Idade , Idoso , Biópsia por Agulha , Diagnóstico Diferencial , Feminino , Humanos , Imuno-Histoquímica , Ceratose Seborreica/diagnóstico , Masculino , Melanoma/diagnóstico , Pessoa de Meia-Idade , Prevalência , Prognóstico , Estudos Retrospectivos , Distribuição por Sexo , Neoplasias Cutâneas/diagnóstico
19.
J Dermatol ; 21(3): 189-93, 1994 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-8014273

RESUMO

We describe here a 35-year-old Japanese woman with mycosis fungoides (MF) who developed numerous, rapidly-growing, seborrheic keratoses on the front of her neck and chest. To the best of our knowledge, this is the first reported case of MF with Leser-Trélat sign from Japan.


Assuntos
Ceratose Seborreica/patologia , Micose Fungoide/patologia , Neoplasias Cutâneas/patologia , Pele/patologia , Adulto , Feminino , Humanos , Japão/epidemiologia , Ceratose Seborreica/epidemiologia , Micose Fungoide/epidemiologia , Neoplasias Cutâneas/epidemiologia
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