Prevalence and genotypic frequency of color vision defects among primary schoolchildren in Adama Town, Eastern Ethiopia.

Color vision deficiency is a common X-linked genetic disorder affecting the day-to-day lives of individuals, in which school-aged children's academic performance can be negatively affected. The aim of this study was to evaluate the prevalence and genotypic frequency of congenital color vision defects (CVD), among primary schoolchildren in Adama, Ethiopia. A school-based cross-sectional study design was used. Students were purposively selected based on their ethnicity but were randomly selected from their sections, resulting in a final sample size estimated at 846 schoolchildren who had received informed consent from their families. Data was gathered using the Ishihara color vision test, 38-plate edition. The result of the study revealed that the total prevalence of CVD was much higher (5.6%) among the male children than that of the females, which was only about 1.79%. The prevalence rates of CVD among the targeted ethnic groups were found to be the highest among Amhara (7.45%) > Oromo (5.00%) > Gurage (2.13%) children, respectively, in descending order. 62.76% of the study subjects were homozygous dominant (AA), followed by those with a heterozygous genotype (Aa) (32.51%), and the remaining 4.73% had recessive (aa) genes.

Prevalence of Congenital Color Vision Deficiency in Southern Taiwan and Detection of Female Carriers by Visual Pigment Gene Analysis.

This study aimed to investigate the prevalence of color vision deficiencies (CVDs) and determine whether carriers could be detected by analyzing the visual pigment genes. Materials and Methods: The data of students who underwent routine CVD screening using the Ishihara color test in Kaohsiung, Southern Taiwan were analyzed. Furthermore, the DNA samples of 80 randomly selected females and four obligate carriers were analyzed. The most upstream genes, downstream genes, and the most downstream genes in the red/green pigment gene arrays were amplified separately using polymerase chain reaction (PCR), and exon 5 of each gene was analyzed. The prevalence of congenital red-green CVD in this study was 3.46% in males and 0.14% in females. The PCR analysis of the first gene, downstream gene, and last gene revealed normal patterns in 73 normal cases. Seven unusual patterns were detected in two proton carriers and five deutan carriers. Among the randomly selected females, 8.8% (7/80) were CVD carriers. The prevalence of CVD among male Taiwanese students in this study was 3.46%. Female carriers of congenital CVD can be identified by molecular analysis of the visual pigment genes. The proportion of CVD carriers among the randomly selected females was 8.8%, which was slightly higher than expected and further studies are warranted.

A large population study reveals a novel association between congenital color vision deficiency and environmental factors.

PURPOSE: To assess the associations between the prevalence of congenital color vision deficiency (CVD) and genetics and environment, represented by place of origin (ethnic background) and place of birth, respectively. METHODS: This is a retrospective study of the computerized database of the northern recruitment center of Israel of 53,895 consecutive male Jewish conscripts 16-19 years old, who completed the medical profiling process between 1988 and 2011. CVD was diagnosed using the 24-pseudo-isochromatic plate Ishihara test. Associations of CVD prevalence with sociodemographic variables, anthropometric indices, refractive errors, and mainly place of origin and place of birth were tested by both univariate analysis and multivariate regression models. RESULTS: Elevated BMI (obesity) and blood pressure (hypertension), as well as myopia, were all positively associated with congenital CVD. The composition of the study population provides a unique opportunity to investigate the relationship between ethnicity and environment. The prevalence of CVD significantly differs among subpopulations of different ethnic background as well as among those who were born in different geographical locations. Additionally, differences in the prevalence of CVD (1.2-1.6%) were observed among conscripts from the same origin, who were born in Israel, compared to those who were born elsewhere. Both place of origin (p < 0.01) and place of birth (p < 0.05) were associated with the prevalence of CVD in a multivariable regression model. CONCLUSION: This study affirms previously established associations of CVD with certain variables and reveals a possible novel association of CVD with environmental factors.

Incidence of dyschromatopsy in glaucoma.

PURPOSE: As proven in studies dating back to the eighteenth century, color vision changes may occur early in the course of glaucoma. Our aim was to reevaluate the incidence of acquired color vision deficiency in glaucoma patients of the University hospital Zürich by using the Panel D-15 test. METHODS: Inclusion criteria of the study involved a diagnosis of glaucoma, age equal or greater than 18 years with no upper limit and a best-corrected visual acuity (BCVA) smaller than ≤ 0.7 logMAR. All volunteers were tested twice monocularly for color vision with (1) the Ishihara color plate test and (2) the Farnsworth and Lanthony Panel D-15 test by one examiner (L.B.). Using the Moment of Inertia Method of Vingrys and King-Smith (Investig Ophthalmol Vis Sci 29(1):50-63, 1988), we measured the color defect type (blue-yellow, red-green or non-selective). RESULTS: One hundred and fifty-one eyes of 87 glaucoma patients were included in this study. Nine eyes showed a deficient result in the Ishihara test, which proves a congenital red-green weakness. Fifty-one (33.8%) eyes showed color vision anomalies in the desaturated test and 24 (15.9%) eyes in the saturated Panel D-15 test. A total of 25.2% and 8.6% of eyes in the desaturated and saturated test were diffuse dyschromatopsia, respectively. The second most prevalent deficiencies were blue-yellow defects with 4.0% and 4.6% of saturated and desaturated results. Just the covariate visual acuity had a significant influence on the Panel D-15 result, whereas other variables like age, sex or intraocular pressure did not show any impact. CONCLUSION: This study ascertains that the long-known theory of color vision defects in patients with glaucoma is also relevant in our sample of 151 eyes, providing continuity to claims firstly reported many years ago. Despite our results highlighting more diffuse dyschromatopsia than other similar experiments, we have also proven that the tritanomalous defects occur more frequently than other color defects.

Prevalence of Color Vision Deficiency in an Adult Population in South Korea.

SIGNIFICANCE: Large differences in failure rates for color vision screening have been reported among different regional groups. However, color vision deficiency prevalence in Korea has only been investigated within a small area of the country. PURPOSE: This study examines the prevalence of failing a color vision screening and its sex-related differences using a sample that is representative of the whole Korean population. METHODS: This population-based cross-sectional study evaluated 2686 subjects (age, 19 to 49 years) who participated in the sixth Korea National Health and Nutrition Examination Survey (2013). Color vision deficiency was assessed using the Hardy-Rand-Rittler (HRR) test by an ophthalmologist. According to standard criteria for the HRR, it classified each subject as color normal, protan, deutan, tritan, or unclassified color vision loss. All participants had comprehensive medical evaluations and ocular history taken. RESULTS: The weighted overall prevalence of color vision deficiency in the Korean population was 3.9% (95% confidence interval, 3.0 to 5.4%). The prevalence of color vision deficiency was higher in male participants (6.5%) than in female participants (1.1%). Among all participants, deutan deficiency (2.5%) had a higher prevalence than did protan deficiency (0.4%). For male participants who failed the HRR screening, deutan-type deficiency was detected most often (64.2%), whereas an unclassified color vision deficiency type was the most common (52.9%) among female participants who failed the HRR screening. As expected, male participants were more likely to fail the HRR screening compared with female participants (prevalence ratio, 6.08; 95% confidence interval, 3.61 to 10.26). CONCLUSIONS: This large population-based study of color vision deficiency among Koreans gives the most accurate estimate of failing a color vision screening test to date and provides useful information for planning adaptive strategies.

Self-perception and determinants of color vision in Parkinson's disease.

Visual dysfunction is common in patients with Parkinson's disease (PD). The objective of this study was to investigate the perceived impact of visual dysfunction and especially color vision loss on PD patients, and to identify retinal and disease factors associated with color vision. Thirty PD patients and thirty-four healthy controls were included. Participants performed the Farnsworth-Munsell Hue-100 test (FMT). Patients answered the National Eye Institute Visual Function Questionnaire (NEI-VFQ), Unified Parkinson's Disease Rating Scale (UPDRS) assessment, and underwent optical coherence tomography with measurement of retinal nerve fiber layer, ganglion cell layer + inner plexiform layer (GCIPL), and outer nuclear and photoreceptor layer. Dopaminergic treatment was assessed as levodopa equivalent dose (LED). Vision domains significantly worse in PD patients compared to normative data were General Vision, Near Activities, Distance Activities, Vision-Specific Dependency, Driving, and Peripheral Vision. Worse NEI-VFQ total scores were associated with worse UPDRS, higher LED, and higher age, but not with FMT, visual acuity, or OCT measures. Only two patients (7%) reported problems with color vision. In contrast, patients performed significantly worse in the FMT than healthy controls and 17 (56.7%) patients were outside the 95th percentile of normative data. In multiple regression analyses, lower LED and higher age were associated with worse color vision in the FMT. PD patients are not aware of color vision deficits. Given the impact of color vision loss on everyday tasks in other conditions, future research should investigate the impact of vision deficits on disease burden in PD.

Prevalence of color blindness among school children in three primary schools of Gish -Abay town district, Amhara regional state, north-west Ethiopia.

BACKGROUND: Although there are limited studies, recent data are lacking to accurately determine the magnitude of color blindness in Ethiopia and there is no evidence of such a study in Gish Abay town district. The purpose of thie study was to assess the prevalence of color blindness among school children in Gish Abaya town district, Ethiopia. METHODS: The study used a community-based analytical cross-sectional study design with multistage cluster random sampling technique from September to October 2016. Three primary schools were selected randomly in the district of Gish Abay town district. Ishihara color plates (24 -edition) was used for color vision test and Snellen' tumbling 'E' chart was used for visual acuity test. The data was analyzed using Statistical Package for Social Sciences (SPSS) version 20 statistical software and binary logistic regression was used to identify factors associated with color blindness. RESULTS: Among a total of 854 subjects, 850 participants with age range of 8-18 years were screened for color vision test giving a response rate of 99.53%. Among the participants, 452 (53.2%) were males and 398 (46.8%) were females. There were 36 (4.24%) cases of impaired color vision. Among these, 27 (3.18%) were males and 9 (1.06%) were females. Out of 36 cases of color blindness, 15 (1.77%) were deutan, 7 (0.82%) were protan and 14(1.65%) were unclassified (both deutan and protan forms). The variables; sex adjusted odds ratio (AOR [95% Confidence Interval] =3.19 [1.45; 6.98], p-value = 0.004); and visual impairment (AOR [95% CI] =4.15 [1.77; 9.75], p-value = 0.001) were significantly associated with color impairment. CONCLUSION: The prevalence of childhood color blindness in Gish Abay town district was relatively similar with other studies in Ethiopia. Sex and visual impairment are factors found to be related with the children's color blindness. Periodical eye examination at the time of school admission is recommended to adjust the children's occupation early in life.

Psychosocial aspects of colour vision deficiency: Implications for a career in medicine.

Colour vision deficiency (CVD) is a common problem and persons with CVD experience difficulties in daily life, early learning and development, education, choice of careers and work performance. Medical professionals with CVD also report difficulties in everyday tasks, training in medicine and performance of medical duties. However, because of limited evidence, the real impact of CVD on the lives of medical professionals is unclear, especially regarding the practice of medicine by doctors. The nature and severity of CVD, awareness of its impact, personal circumstances and the ability to cope with the deficiency are the major factors that determine the impact of CVD. However, there is a paucity of methodologically sound research on social and psychological aspects of CVD. Currently, early detection, enhancing awareness and offering support are the only proven ways of helping medical professionals with CVD. With the growing emphasis on equality and inclusivity of those with deficiencies, it is desirable to strike a balance between concerns about patient care and the rights of medical professionals with CVD to pursue their careers. Therefore, any future research also needs to focus on psychological aspects of CVD while exploring its impact on a career in medicine.

Factors associated with impaired color vision without retinopathy amongst people with type 2 diabetes mellitus: a cross-sectional study.

BACKGROUND: Patients with type 2 diabetes mellitus (T2DM) may develop color vision impairment. This study aimed to determine the prevalence and factors associated with impaired color vision in patients with T2DM but without diabetic retinopathy. METHODS: Enrolment criteria included multi-ethnic Asian participants, age 21 to 80 years, with known T2DM for a minimum of 2 years. Their diagnoses were affirmed from oral glucose tolerance test results and they were screened for impaired color vision using the Farnsworth D-15 instrument. Demographic characteristics were described and clinical data for the preceding 2 years were analyzed using logistic regression. RESULTS: Twenty-two percent of 849 eligible participants had impaired color vision with higher involvement of the right eye. Impaired blue-yellow color-vision(Tritanomaly) was the commonest impaired color vision. Participants with impaired color vision were significantly associated with age and lower education; longer duration of T2DM (median 6 years vs 4 years); higher HbA1c level and HDL-Cholesterol in 2nd year; lower mean total cholesterol, mean LDL-Cholesterol and mean triglyceride in 2nd year. They also have poorer vision beyond 6/12 in the affected eye. Logistic regression showed that impaired color vision was associated with older patients (OR=1.04), increased duration of T2DM (OR=1.07); prescription of Tolbutamide (OR=3.79) and lower mean systolic blood pressure (OR=0.98). CONCLUSION: Almost one in four participants with T2DM had impaired color vision, largely with tritanomaly. Color vision screening may be considered for participants who develop T2DM for 6 years or longer, but this requires further cost-effectiveness evaluation.

Preparing medical students with congenital colour vision deficiency for safe practice.

BACKGROUND: Colour vision of candidates is tested in many medical colleges in India at the time of admission to undergraduate courses; however, there are no guidelines, and therefore no counselling, on how students with congenital colour vision deficiency (CCVD) should negotiate the medical course, and how best they can practise safely after graduation. Problems in interpreting coloured signs may lead to misdiagnosis. This study aimed to explore difficulties during clinical work that requires colour discrimination, and to offer suggestions on safe practice based on the findings and a review of the literature. METHODS: We did a cross-sectional study after obtaining institutional ethical clearance and written informed consent. Thirty volunteer medical students with CCVD (≥3 errors on Ishihara chart) were matched with 30 volunteers from their own batch who made no errors. All participants interpreted colour-dependent clinical and laboratory photographs. RESULTS: Students with CCVD made more errors (range 5-26; mean [SD] 13.17 [5.873] out of 75 items in 35 colour-dependent photographs) than colour-normal students (range 2-13; mean [SD] 5.53 [3.037], p<0.001). The nature of the errors suggested that medical students with CCVD could have problems in learning histology, pathology, haematology, microbiology, dermatology, paediatrics, medicine, biochemistry and during ophthalmoscopy. CONCLUSIONS: Screening at the time of admission will make students aware of their CCVD status and, through conscious practice thereafter, they may understand their limitations. Faculty could guide and prepare such students for safe practice.

Achromatopsia in three sibling Labrador Retrievers in the UK.

Achromatopsia was identified in three Labrador Retriever littermates. The dogs demonstrated day blindness, negotiating obstacles under low-light conditions, but apparently blind when outdoors. One of the dogs presented with immature bilateral diffuse posterior cortical cataracts and clinical signs of day blindness became apparent following cataract extraction surgery. Electroretinography demonstrated an absence of a cone photoreceptor response to a bright stimulus and a flicker response of 30 Hz in all three dogs. No fundic lesions have been apparent ophthalmoscopically in any of the dogs as the initial presentation of each case. No abnormalities were detected with DNA screening for known mutations of the CNGB3 gene in any of the dogs.

Prevalence of congenital colour vision deficiency among secondary school students in Ibadan, South-West Nigeria.

AIM: The aim was to determine the prevalence and pattern of congenital colour vision deficiency among secondary school students in Ibadan, Nigeria. SUBJECTS AND METHODS: A descriptive cross-sectional study was conducted among students from three public secondary schools through a multi-staged sampling method. Ocular examination including visual acuity assessment and colour vision test with the Ishihara plate was performed for all students. Further assessment with the Farnsworth-Munsell D-15 panel was performed for those who failed the Ishihara test. RESULTS: One thousand six hundred and thirty-five students participated in the study. There were 769 (47.0%) males with mean age of 13.9 ± 1.9 years. The overall prevalence of congenital colour vision deficiency was 2.3% with prevalence of 3.8% and 0.9% in males and females, respectively, which was statistically significant (P = 0.00112), and equal proportion of deutans 11 (32.0%) and protans 12 (35.0%) ratio of 1:1.1. CONCLUSION: The prevalence of congenital colour vision deficiency among public secondary school students in Ibadan is comparable to findings in other parts of the country.

Prevalence of ocular abnormalities in prediabetic patients.

AIM: The aim of our study was to evaluate the prevalence of ocular abnormalities in prediabetic individuals. MATERIAL AND METHODS: 61 subjects aged 37-78 (41 women, 20 men), with impaired fasting glucose and/or impaired glucose tolerance, were enrolled in the study and compared to 30 healthy volunteers, aged 39-75 (20 women, 10 men), without prediabetes and history of previous ocular diseases. Both groups of patients underwent a complete physical examination, biochemical tests and ophthalmic examination: visual acuity testing, intraocular pressure measurement, anterior and posterior segment evaluation, fundus photographs, optical coherence tomography, colour vision and letter contrast sensitivity tests. RESULTS: The prevalence rates of various ocular abnormalities in prediabetic subjects as compared to healthy controls were as follows: acquired colour vision impairment 8.2% vs. 0% (p<0.05), signs of retinopathy: 9.8% vs. 0% (p<0.05), cataract: 32.8%/ vs. 6.7% (p<0.05), and corneal surface disorders: 19.7% vs. 3.3% (p<0.05). Optical coherence tomography revealed increased prevalence of posterior vitreous detachments and epiretinal membranes in prediabetic individuals as compared to healthy controls. There were no statistically significant differences in central retinal thickness, mean visual acuity and mean intraocular pressure between the two groups. CONCLUSION: Patients with prediabetes present with numerous ocular abnormalities. The prevalence of ocular disorders in prediabetic subjects is significantly higher as compared to healthy population. Regular ophthalmic monitoring seems to be essential at this stage of hyperglycemic disorders. A dedicated prevention and screening programs should be implemented in prediabetic population in order to early detect ocular abnormalities and identify individuals at risk of other diabetic complications.

Color vision deficiency in Zahedan, Iran: lower than expected.

PURPOSE: To estimate the prevalence of congenital red-green color vision defects in the elementary school students of Zahedan in 2012. METHODS: In this cross-sectional study, 1000 students with a mean (±SD) age of 9.0 (±1.4) years were selected randomly from a large primary school population. Color vision was evaluated using the Ishihara pseudoisochromatic color plates (38-plate edition). A daylight fluorescent tube was used as an illuminant C equivalent (i.e., 860 lux, color rendering index greater than 92, and color temperature = 6500 K). Having more than three misreadings on the test was considered a failing criterion. Data were analyzed in SPSS version 17 software using χ2 tests. RESULTS: Nine students (0.9%) made more than three errors on the Ishihara test. Based on this criterion, the prevalence of red-green color vision deficiency in girls and boys was 0.2 and 1.6% (p = 0.02), respectively. CONCLUSIONS: The prevalence of red-green color vision deficiency was found to be significantly lower in Zahedan than comparable reports in the literature.

Color vision deficiency in a middle-aged population: the Shahroud Eye Study.

The aim of this study was to determine the prevalence of color vision defects in the middle-age population of Shahroud, Iran. We selected 6,311 people from the 40- to 64-year-old population through random cluster sampling. Color vision testing was performed with the Farnsworth D-15. Cases with similar and symmetric results in both eyes were classified as hereditary, and those with asymmetric results were considered acquired. Cases that did not conform to standard patterns were classified as unknown category. Of 5,190 respondents (response rate 82.2 %), 5,102 participants underwent the color vision test. Of these, 14.7 % (95 % confidence interval 13.7-15.6) had some type of color vision deficiency. Of the 2,157 male participants, 6.2 % were hereditary and 10.2 % were acquired and of the 2,945 female participants, 3.1 % were hereditary and 10 % were acquired. Hereditary color deficiencies were mostly of the deutan form (63.8 %), and acquired deficiencies were mostly tritan (66.1 %). The prevalence of hereditary and acquired color vision deficiency, as well as different types of red-green and blue-yellow color vision defects significantly increased with age (p < 0.001). In conclusion, the pattern of color vision defects among the middle-aged population of Shahroud was significantly different from that seen in the younger population. This could be due to changes associated with age, gender, medical and ocular conditions, and differences in race and environment. Thus, results of previous examinations and the overall health status should be considered before making any judgment about the status of color vision in middle-aged people.

Blue-yellow colour vision impairment and cognitive deficits in occasional and dependent stimulant users.

Specific blue-yellow colour vision impairment has been reported in dependent cocaine users and it was postulated that drug-induced changes in retinal dopamine neurotransmission are responsible. However, it is unclear whether these changes are confined to chronic cocaine users, whether they are specific for dopaminergic stimulants such as cocaine and amphetamine and whether they are related to cognitive functions such as working memory, encoding and consolidation. In 47 occasional and 29 dependent cocaine users, 23 MDMA (commonly known as 'ecstasy') users and 47 stimulant-naive controls, colour vision discrimination was measured with the Lanthony Desaturated Panel D-15 Test and memory performance with the Auditory Verbal Learning Test. Both occasional and dependent cocaine users showed higher colour confusion indices than controls. Users of the serotonergic stimulant MDMA (26%), occasional (30%) and dependent cocaine users (34%) exhibited more frequent blue-yellow colour vision disorders compared to controls (9%). Inferior performance of MDMA users was caused by a subgroup with high amphetamine co-use (55%), while MDMA use alone was not associated with decreased blue-yellow discrimination (0%). Cognitive performance was worse in cocaine users with colour vision disorder compared to users and controls with intact colour vision and both colour vision impairment and cognitive deficits were related to cocaine use. Occasional cocaine and amphetamine use might induce blue-yellow colour vision impairment, whereas the serotonergic stimulant MDMA does not impair colour vision. The association between colour vision impairment and cognitive deficits in cocaine users may reflect that retinal and cerebral dopamine alterations are linked to a certain degree.

Trichromatic and dichromatic relative sensitivity to green light in a mild hypoxic environment.

INTRODUCTION: Several studies have reported that individuals with normal color vision have a relative decrease in sensitivity to green light in hypoxic environments approximating altitudes above 4000 m. Because there is little available information describing the effects of mild hypoxic environments (less than 4000 m) in subjects with deficient color-vision, we examined the effect of mild hypoxia on the relative sensitivity to green light for color-normal and color-deficient subjects. METHODS: Relative sensitivity to the green light was measured using the Medmont C-100 at ground and 3780 m in an altitude chamber. There were 30 subjects, 13 with normal color vision and 17 with a congenital red-green defect, who participated in the study. The relative sensitivity to the green light was determined from the average of four settings measured during the 4.5-h trial. RESULTS: Color-normals and anomalous trichromats showed a small decrease in the relative sensitivity to the green light at 3780 m compared to ground. In contrast to the trichromatic results, the relative sensitivity of the dichromats to the green light did not differ between 3780 m and ground. DISCUSSION: Our results show that a decrease in the relative sensitivity to green light can occur in hypoxic environments that are equivalent to altitudes greater than 3700 m in individuals with trichromatic but not dichromatic color vision. Although the change in sensitivity was significant, it was small and unlikely to have any operational impact.

Visual impairment and road traffic accidents among drivers in Jimma Town, Southwest Ethiopia.

BACKGROUND: Vision play a vital role in driving where good and efficient visual functioning of the driver is essential. Any significant loss of visual function will diminish a driver's ability to operate a motor vehicle safely and will thus contribute to road traffic injury. However, there is little evidence indicating that defects of vision alone cause road traffic accidents. OBJECTIVE: To determine the impact of visual impairment and other factors on road traffic accident among vehicle drivers. METHODS: A cross-sectional descriptive study was conducted on 249 sampled drivers in Southwest Ethiopia. A pretested interviewer led questionnaire was used for interview and vision tests were done using Snellen's acuity chart and Ishihara pseudo-isochromatic plates. Statistical analyses were performed using SPSS version 16.0. RESULTS: The mean age of drivers was 33.6 years (SD +/- 10.3). The relative frequency of self reported road traffic accident was 15.3%. The prevalence of uncorrected binocular visual impairment was 1.6% and there was a significant association between visual impairment and road traffic accident (P < 0.05). Uncorrected refractive error was seen in 7.6% and 8.8% of drivers in the right and left eyes respectively, and 3.2% of them had vision less than what is required to obtain driving license (visual acuity of 6/12). None of the drivers with refractive errors were wearing appropriate corrections. Color vision impairment was seen in 1.6% of the drivers. A significant proportion (9.6%) of the drivers did not have eye exam for their driving license. CONCLUSION: Uncorrected binocular visual impairment was strongly associated with road traffic accident. There is need for consistent inspection and screening, strict rules and regulations of licensing and health education for drivers to minimize road traffic accident.

[Risk factors in the results of the colour vision test Roth 28-hue (E) desaturated in glaucoma patients]. / Einflussfaktoren auf die Ergebnisse des Farbpigmentprobentests Roth 28-hue (E) desaturiert bei Glaukompatienten.

BACKGROUND: Glaucoma is an ocular disease with typical progressive damage of the optic nerve. In the past it was postulated that glaucoma induces acquired colour vision disorders. Until now all studies about glaucoma and colour vision disorders did not include vascular risk factors. In the present study we determined several vascular risk factors concerning the results of the colour vision test Roth 28-hue (E) desaturated in glaucoma patients. PATIENTS AND METHODS: On the basis of an analysis of variance (ANOVA) we determined the influence of several risk factors, such as arteriosclerotic and vasospastic risk factors, on the results of the colour vision test Roth 28-hue (E) desaturated in glaucoma patients. 353 glaucoma patients were included in this study. RESULTS: We detected a strong influence of age and mean defect in perimetry and an additional effect of arteriosclerotic and vasospastic risk factors on the results of the colour vision test Roth 28-hue (E) desaturated in glaucoma patients. CONCLUSIONS: We suspect that arteriosclerotic and vasospastic risk factors independently to glaucoma have an influence on colour vision. In the future attention additionally has to be given to vascular risk factors in the colour vision testing of glaucoma patients.