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1.
J Obstet Gynaecol Res ; 46(5): 673-677, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32077210

RESUMO

Gestational psittacosis is a rare disease that is associated with significant maternal and fetal morbidity and mortality. Currently, there is no examination method which allows for a quick diagnosis. We report a case of gestational psittacosis that could not be diagnosed as psittacosis during treatment and resulted in maternal and fetal death despite intensive treatment. We also reviewed 23 cases of gestational psittacosis. Fetal and maternal mortality was 82.6% (19/23) and 8.7% (2/23), respectively. In pregnant women with high fever and flu-like symptoms, we should suspect Chlamydia psittaci infection if at least one of the following is present; contact with sheep, parrots, parakeets or goats; normal or moderately decreased leucocyte count, thrombocytopenia and hepatic and/or renal dysfunction; cough and/or lobe consolidation or infiltration on chest X-ray. Antibiotic therapy with macrolide prenatally, macrolide or tetracycline postnatally and termination of pregnancy should be considered.


Assuntos
Complicações Infecciosas na Gravidez/diagnóstico , Psitacose/diagnóstico , Adulto , Animais , Chlamydophila psittaci/isolamento & purificação , Vetores de Doenças , Feminino , Humanos , Morte Materna , Placenta/microbiologia , Gravidez , Complicações Infecciosas na Gravidez/mortalidade , Psitacose/mortalidade , Psitacose/veterinária , Natimorto
2.
Front Immunol ; 12: 645653, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34093535

RESUMO

Chlamydia psittaci (C. psittaci) is a common zoonotic agent that affects both poultry and humans. Interleukin 10 (IL-10) is an anti-inflammatory factor produced during chlamydial infection, while dendritic cells (DCs) are powerful antigen-presenting cells that induce a primary immune response in the host. However, IL-10 and DCs regulatory mechanisms in C. psittaci infection remain elusive. In vivo and in vitro investigations of the regulatory mechanisms were performed. IL-10-/- mice, conditional DCs depletion mice (zinc finger dendritic cell-diphtheria toxin receptor [zDC-DTR]), and double-deficient mice (DD, IL-10-/-/zDCDTR/DTR) were intranasally infected with C. psittaci. The results showed that more than 90% of IL-10-/- mice, 70% of wild-type mice, and 60% of double-deficient mice survived, whereas all zDC-DTR mice died. A higher lymphocyte proliferation index was found in the IL-10 inhibitor mice and IL-10-/- mice. Moreover, severe lesions and high bacterial loads were detected in the zDC-DTR mice compared with double-deficient mice. In vitro studies revealed increased OX40-OX40 ligand (OX40-OX40L) activation and CD4+T cell proliferation. Besides, the expression of indoleamine 2, 3-dioxygenase (IDO), and regulatory T cells were significantly reduced in the co-culture system of CD4+ T cells and IL-10-/- DCs in C. psittaci infection. Additionally, the activation of the NLR family pyrin domain-containing 3 (NLRP3) inflammasome increased to facilitate the apoptosis of DCs, leading to rapid clearance of C. psittaci. Our study showed that IL-10-/- upregulated the function of deficient DCs by activating OX40-OX40L, T cells, and the NLPR3 inflammasome, and inhibiting IDO, and regulatory T cells. These effects enhanced the survival rate of mice and C. psittaci clearance. Our research highlights the mechanism of IL-10 interaction with DCs, OX40-OX40L, and the NLPR3 inflammasome, as potential targets against C. psittaci infection.


Assuntos
Células Dendríticas/imunologia , Indolamina-Pirrol 2,3,-Dioxigenase/fisiologia , Interleucina-10/fisiologia , Proteína 3 que Contém Domínio de Pirina da Família NLR/fisiologia , Ligante OX40/fisiologia , Psitacose/imunologia , Linfócitos T Reguladores/imunologia , Animais , Feminino , Pulmão/microbiologia , Pulmão/patologia , Ativação Linfocitária , Camundongos , Camundongos Endogâmicos C57BL , Psitacose/mortalidade , Transdução de Sinais/fisiologia
3.
J Wildl Dis ; 54(2): 248-260, 2018 04.
Artigo em Inglês | MEDLINE | ID: mdl-29369723

RESUMO

In 2013, a mortality event of nonnative, feral Rosy-faced Lovebirds ( Agapornis roseicollis) in residential backyards in Maricopa County, Arizona, US was attributed to infection with Chlamydia psittaci. In June 2014, additional mortality occurred in the same region. Accordingly, in August 2014 we sampled live lovebirds and sympatric bird species visiting backyard bird feeders to determine the prevalence of DNA and the seroprevalence of antibodies to C. psittaci using real-time PCR-based testing and elementary body agglutination, respectively. Chlamydia psittaci DNA was present in conjunctival-choanal or cloacal swabs in 93% (43/46) of lovebirds and 10% (14/142) of sympatric birds. Antibodies to C. psittaci were detected in 76% (31/41) of lovebirds and 7% (7/102) of sympatric birds. Among the sympatric birds, Rock Doves ( Columba livia) had the highest prevalence of C. psittaci DNA (75%; 6/8) and seroprevalence (25%; 2/8). Psittacine circovirus 1 DNA was also identified, using real-time PCR-based testing, from the same swab samples in 69% (11/16) of species sampled, with a prevalence of 80% (37/46) in lovebirds and 27% (38/142) in sympatric species. The presence of either Rosy-faced Lovebirds or Rock Doves at residential bird feeders may be cause for concern for epizootic and zoonotic transmission of C. psittaci in this region.


Assuntos
Agapornis , Doenças das Aves/microbiologia , Chlamydophila psittaci/isolamento & purificação , Columbidae , Passeriformes , Psitacose/veterinária , Agapornis/microbiologia , Animais , Animais Selvagens , Arizona/epidemiologia , Doenças das Aves/epidemiologia , Doenças das Aves/mortalidade , Columbidae/microbiologia , Passeriformes/microbiologia , Psitacose/epidemiologia , Psitacose/microbiologia , Psitacose/mortalidade
4.
Rev Esp Salud Publica ; 79(5): 591-7, 2005.
Artigo em Espanhol | MEDLINE | ID: mdl-16471138

RESUMO

BACKGROUND: Psittacosis can be transmitted to humans from infected birds, being the cause of atypical pneumonia. This work is aimed at determining the source of a psittacosis outbreak, the characteristics of the subjects exposed and describing the measures to control the outbreak. METHODS: Descriptive study. Notification to the Epidemiological Monitoring System and Autonomic Agriculture authorities, taking the pertinent measures (inspection, sampling, disinfecting and precautionary quarantine of birds), closing the establishment. Case definition and epidemiological survey. Frequency analysis. RESULTS: Seventeen (17) individuals (one of whom died) came into contact with suspicious animals (53% males/47% females), nine of whom (mean age: 30) showed symptoms (100% fever, flu-like symptoms 44.4%). A serology was performed for C. psitacci on 11 of the 17 subjects exposed (68.75%), two of whom (18.18%) tested positive. The presence of C. psittaci DNA was detected in the pulmonary tissue study conducted on the deceased individual. A total of 33% (3/9) of those showing symptoms were confirmed by diagnosis. The Autonomic Agriculture authorities placed 22 animal compounds under quarantine. A total of seven (10%) of the 70 samples taken (60: animal cloacas and 10 birds) revealed a positive antigen, the PCR nucleic acid test being positive in one there-of. CONCLUSIONS: The exposure to diseased animals at the establishments involved caused the outbreak, the common source of contagion being of an occupational nature. The appropriate coordination/collaboration between the local Health and Agriculture authorities made it possible to prevent any further cases from arising.


Assuntos
Surtos de Doenças , Psitacose/epidemiologia , Zoonoses , Adulto , Chlamydophila psittaci/genética , Chlamydophila psittaci/isolamento & purificação , DNA Bacteriano/análise , Feminino , Humanos , Pulmão/microbiologia , Masculino , Psitacose/diagnóstico , Psitacose/microbiologia , Psitacose/mortalidade , Psitacose/prevenção & controle , Espanha/epidemiologia
5.
Avian Dis ; 43(4): 798-803, 1999.
Artigo em Inglês | MEDLINE | ID: mdl-10611999

RESUMO

In a flock of 12,000 bobwhite quail (Colinus virginianus) and 7200 chukar partridge (Alectoris chukar), the owner had 100% morbidity and 40%-50% mortality in birds between the ages of 2 and 4 wk. Affected birds were stunted and anorexic and had yellow/green diarrhea. Two- and 4-wk-old birds submitted for necropsy all had slight nasal discharge. Histopathologic examination revealed mild (bobwhite) to severe (chukar) rhinitis. Immunohistochemistry was positive for Chlamydia psittaci in all birds. Chlamydia psittaci organisms were demonstrated histopathologically in hematoxylin and eosin and Gimenez-stained slides. Management sanitation and treatment with chlortetracycline stopped further excessive losses. The owners were also infected. Treatment by their local physician with tetracycline alleviated symptoms.


Assuntos
Surtos de Doenças/veterinária , Psitacose/epidemiologia , Animais , Aves , Chlamydophila psittaci/isolamento & purificação , Colinus , Pálpebras/patologia , Kentucky/epidemiologia , Pulmão/patologia , Morbidade , Psitacose/mortalidade , Psitacose/terapia
6.
J Am Vet Med Assoc ; 197(5): 600-1, 1990 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-2211307

RESUMO

Chlamydia psittaci was believed responsible for an episode of high perinatal death loss in a swine herd in which 8.5 pigs per litter normally were weaned. In this episode, 18 sows produced 186 pigs, with 50 survivors. Chlamydia was found in tissue samples, and other bacterial or viral pathogens could not be identified. Chlamydia was diagnosed by isolation (ELISA), histologic examination using immunoperoxidase staining techniques, and electron microscopy. Previously, C psittaci has not been considered in the differential diagnosis of swine perinatal mortality.


Assuntos
Psitacose/veterinária , Doenças dos Suínos/mortalidade , Animais , Animais Recém-Nascidos , Chlamydophila psittaci/isolamento & purificação , Psitacose/mortalidade , Suínos
7.
J Zoo Wildl Med ; 35(1): 94-6, 2004 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-15193081

RESUMO

Fifty-eight blue-fronted Amazon parrot (Amazona aestiva) nestlings, recovered from the illegal trade, became ill at a wildlife rehabilitation center in São Paulo State, Brazil. Clinical signs observed were nonspecific, and the mortality rate was 96.5% despite initial treatment with norfloxacin. Postmortem examinations were performed on 10 birds. Liver and spleen smears showed structures suggestive of Chlamydophila psittaci in four cases. Diagnosis was confirmed by seminested polymerase chain reaction on tissue samples. Other birds from the same location showed no clinical signs of the disease, although high complement fixation titers to C. psittaci were found in 10 adult psittacines. All birds in the facility were treated with doxycycline. The two surviving nestlings did not recover after two doxycycline treatments and were euthanatized. The high mortality rate observed in this outbreak was attributed to poor conditions of husbandry and delays in the diagnosis and treatment of the disease. After diagnosis, improved control measures for chlamydiosis were instituted.


Assuntos
Doenças das Aves/epidemiologia , Chlamydophila psittaci/patogenicidade , Surtos de Doenças/veterinária , Papagaios , Psitacose/veterinária , Criação de Animais Domésticos/métodos , Animais , Antibacterianos/uso terapêutico , Doenças das Aves/microbiologia , Doenças das Aves/mortalidade , Brasil/epidemiologia , Chlamydophila psittaci/isolamento & purificação , Doxiciclina/uso terapêutico , Feminino , Masculino , Psitacose/epidemiologia , Psitacose/mortalidade , Fatores de Tempo
8.
PLoS One ; 7(11): e50327, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-23189195

RESUMO

The complement system modulates the intensity of innate and specific immunity. While it protects against infections by extracellular bacteria its role in infection with obligate intracellular bacteria, such as the avian and human pathogen Chlamydia (C.) psittaci, is still unknown. In the present study, knockout mice lacking C3 and thus all main complement effector functions were intranasally infected with C. psittaci strain DC15. Clinical parameters, lung histology, and cytokine levels were determined. A subset of infections was additionally performed with mice lacking C5 or C5a receptors. Complement activation occurred before symptoms of pneumonia appeared. Mice lacking C3 were ∼100 times more susceptible to the intracellular bacteria compared to wild-type mice, with all C3(-/-) mice succumbing to infection after day 9. At a low infective dose, C3(-/-) mice became severely ill after an even longer delay, the kinetics suggesting a so far unknown link of complement to the adaptive, protective immune response against chlamydiae. The lethal phenotype of C3(-/-) mice is not based on differences in the anti-chlamydial IgG response (which is slightly delayed) as demonstrated by serum transfer experiments. In addition, during the first week of infection, the absence of C3 was associated with partial protection characterized by reduced weight loss, better clinical score and lower bacterial burden, which might be explained by a different mechanism. Lack of complement functions downstream of C5 had little effect. This study demonstrates for the first time a strong and complex influence of complement effector functions, downstream of C3 and upstream of C5, on the outcome of an infection with intracellular bacteria, such as C. psittaci.


Assuntos
Chlamydophila psittaci/imunologia , Proteínas do Sistema Complemento/imunologia , Pneumonia/imunologia , Psitacose/imunologia , Animais , Carga Bacteriana , Líquido da Lavagem Broncoalveolar/imunologia , Ativação do Complemento/imunologia , Complemento C3/genética , Complemento C3/imunologia , Complemento C3/metabolismo , Complemento C5/imunologia , Complemento C5/metabolismo , Proteínas do Sistema Complemento/metabolismo , Citocinas/imunologia , Citocinas/metabolismo , Suscetibilidade a Doenças/imunologia , Granulócitos/imunologia , Granulócitos/metabolismo , Imunoglobulina G/imunologia , Imunoglobulina M/imunologia , Pulmão/imunologia , Pulmão/microbiologia , Pulmão/patologia , Masculino , Camundongos , Camundongos Knockout , Peroxidase/metabolismo , Pneumonia/genética , Pneumonia/microbiologia , Pneumonia/mortalidade , Psitacose/genética , Psitacose/microbiologia , Psitacose/mortalidade , Receptores de Complemento/genética , Receptores de Complemento/imunologia , Baço/imunologia , Baço/microbiologia
11.
Vet Med Nauki ; 23(8): 40-6, 1986.
Artigo em Búlgaro | MEDLINE | ID: mdl-3811213

RESUMO

An attempt was made to analyze comparatively the intensity of the epizootic process in young female sheep, ewes (second pregnancy, with no records of abortions in their first pregnancy) and their lambs either with an infection of Salmonella abortus ovis only or with a mixed infection of S. abortus ovis and Chlamydia psittaci var. ovis. This was reached through following up and studying the parameters morbidity, mortality, lethality, index of infectedness, index of deadlines, and fertility. It was found that the intensity of the apparent epizootic process was highest with young females affected with a mixed infection, and it was lowest with ewes affected with a pure infection (Salmonella abortion). The intensity of the inapparent epizootic process was best manifested in the young females affected with a pure Salmonella abortion. With these animals both the index of infectedness and the index of deadlines had highest values.


Assuntos
Aborto Animal/epidemiologia , Surtos de Doenças/veterinária , Psitacose/veterinária , Salmonelose Animal/epidemiologia , Doenças dos Ovinos/epidemiologia , Aborto Animal/mortalidade , Animais , Bulgária , Feminino , Gravidez , Psitacose/epidemiologia , Psitacose/mortalidade , Salmonelose Animal/mortalidade , Ovinos , Doenças dos Ovinos/mortalidade
12.
Br Med J ; 1(5791): 1-2, 1972 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-5061782
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