Expression of smooth-muscle actin in cultured cells from human plasmacytoid myoepithelioma / Expressão da actina do músculo liso em cultura de células de mioepitelioma plasmacitoide humano
Oral surg. oral med. oral pathol. oral radiol. endod
; 84(6): 663-7, Dec. 1997. ilus
Article
en En
| BBO
| ID: biblio-852794
Biblioteca responsable:
BR97.1
Ubicación: BR97.1
ABSTRACT
The definition of plasmacytoid myoepithelioma, a neoplasm exhibiting myoepithelial differentiation, has been recently questioned. To better understand the histogenesis of this neoplasm, we searched for myoepithelial markers in histologic sections of plasmacytoid myoepithelioma and in a cell line (M1) derived from this same neoplasm study design:
expression of vimentin, pan-keratin (AE-3) and smooth-muscle actin was studied by immunohistochemistry in paraffin-embedded tissue and by immunofluorescence in M1 cells.Results:
plasmacytoid myoepithelioma tumor sections showed vimentin and AE-3 reactivity, but evidence of smooth-muscle actin was not seen. The cell line derived from this tumor also produced vimentin and cytokeratin. In addition, all cultured cells expressed smooth-muscle actin.Conclusion:
we demonstrated that cells derived from a case of plasmacytoid myoepithelioma appear to show full myoepithelial differentiation in vitro. Thus, they are myoepithelial-like cells in nature. The lack of myogenous differentiation in vivo could be due to an inhibitory process mediated by the extracellular matrix
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Colección:
06-national
Banco de datos:
BBO
Asunto principal:
Neoplasias de la Boca
/
Mioepitelioma
/
Técnicas de Cultivo de Célula
Límite:
Female
/
Humans
Idioma:
En
Revista:
Oral surg. oral med. oral pathol. oral radiol. endod
Año:
1997
Tipo del documento:
Article