Molecular diagnosis of Huntington's disease in Mexican patients by polymerase chain reaction
Arch. med. res
; 27(1): 87-92, 1996. ilus, tab
Article
en En
| LILACS
| ID: lil-200297
Biblioteca responsable:
MX1.1
ABSTRACT
Three highly informative markers genetically linked to Huntington's Disease (HD) were used for diagnosis of HD in Mexican patients, two polymorphic HindIII sites located at D4S10 locus and one VNTR marker at D4S111 locus (VNTR-111). Forty chromosomes from healthy sybjects were tested in order to evaluate the informativeness of the probes. The RFLP HindIII 1 and 2 and the VNTR-111 probes showed a heterozygosity of 0 percent, 45 percent, and 60 percent, respectively. Five families were analyzed, of these, only in two the markers used were informative. In one of them, six membrers showed a decreased risk of inheritance of the mutant gene for Huntington's Didease with 95 percent accuracy
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Colección:
01-internacional
Banco de datos:
LILACS
Asunto principal:
ADN
/
Marcadores Genéticos
/
Reacción en Cadena de la Polimerasa
/
Factores de Riesgo
/
Enfermedad de Huntington
/
Genética Médica
/
Genética de Población
/
Enfermedades Genéticas Congénitas
/
México
/
Biología Molecular
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Límite:
Humans
País/Región como asunto:
Mexico
Idioma:
En
Revista:
Arch. med. res
Asunto de la revista:
MEDICINA
Año:
1996
Tipo del documento:
Article