Mutación del gen K-ras en tumores pancreático-biliares / Frequency of K-ras mutation in biliary and pancreatic tumors
Rev. méd. Chile
; 133(12): 1434-1440, dic. 2005. tab
Article
en Es
| LILACS
| ID: lil-428526
Biblioteca responsable:
BR1.1
ABSTRACT
Background:
The ras gene family (H-ras, N-ras and K-ras) are oncogenes that mutate frequently in human cancer, specially in tumors of the biliary tract and pancreas.Aim:
To determine the frequency of K-ras gene codon 12 mutation in pancreatic and biliary tumors. Material andMethods:
Samples of 35 gallbladder, 15 ampulla of Vater, 10 biliary tract and 9 pancreatic tumors, were analyzed. The tumor tissue was microdissected from paraffin embedded biopsies. The mutation was detected by a combination of polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).Results:
Overall, 46% of samples had K-ras gene mutations. Mutation frequency was 80, 56, 50 and 29% for ampulla of Vater, pancreatic, biliary tract and gallbladder tumors, respectively. When compared with the rest, gallbladder tumors had a significantly lower frequency of the mutation. Median survival for biliary tract tumors was 6 months, compared with 65 months for gallbladder tumors (p <0.05).Conclusions:
Gallbladder carcinoma had the lower frequency of K-ras mutation, when compared with pancreatic, biliary tract and ampulla of Vater tumors.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
LILACS
Asunto principal:
Neoplasias Pancreáticas
/
Carcinoma
/
Genes ras
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Neoplasias de la Vesícula Biliar
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Mutación
Límite:
Adult
/
Aged
/
Aged80
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Female
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Humans
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Male
Idioma:
Es
Revista:
Rev Med Chil
/
Rev. méd. Chile
/
Rev. méd. Chile (En línea)
/
Revista médica de Chile
Asunto de la revista:
MEDICINA
Año:
2005
Tipo del documento:
Article
/
Project document
País de afiliación:
Chile