Expression of core binding factor Osf2/Cbfa-1 and bone sialoprotein in tooth development.
Mech Dev
; 81(1-2): 169-73, 1999 Mar.
Article
en En
| MEDLINE
| ID: mdl-10330494
ABSTRACT
The transcription factor Osf2/Cbfa1 is a key regulator of osteogenic differentiation while BSP, a major non-collagenous protein, is a marker of osteoblastic differentiation. To determine the relationship between Osf2/Cbfa1 and the formation of mineralized tissues in tooth development we have studied the temporal expression of Osf2/Cbfa1 and BSP mRNA using in situ hybridization. These studies show that Osf2/Cbfa1 is expressed early in mesenchymal and epithelial tissues destined to form the mineralized tissues of the tooth and periodontal tissues, whereas BSP provides a specific marker for the differentiated cells in each of these tissues. Expression of Osf2/Cbfa1, but not BSP, was observed in the periodontal ligament indicating that expression of Osf2/Cbfa1 is not restricted to mineralizing tissues.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sialoglicoproteínas
/
Diente
/
Factores de Transcripción
/
Proteínas de Neoplasias
Límite:
Animals
Idioma:
En
Revista:
Mech Dev
Asunto de la revista:
EMBRIOLOGIA
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos