Parvovirus infection mimicking systemic lupus erythematosus in a pediatric population.
Semin Arthritis Rheum
; 28(5): 314-8, 1999 Apr.
Article
en En
| MEDLINE
| ID: mdl-10342388
ABSTRACT
OBJECTIVES:
To assess the striking similarities of presentation in a pediatric population between human parvovirus B19 (HPV-B19) infection and systemic lupus erythematous (SLE).METHODS:
Medical records of seven patients (ages 6 to 15) with HPV-B19 infection were reviewed retrospectively.RESULTS:
Six of seven cases presented with a history of malar rash, and all seven had prolonged arthralgias and fatigue. Six of seven had a positive antinuclear antibody (ANA) titer ranging from 140 to greater than 1640, with two patients having antibodies to Scl-70 and others to Sm, RNP, SS-A (Ro), or SS-B (La). The erythrocyte sedimentation rate (ESR) varied from 2 to 68 mm/h. Two patients presented with elevated rheumatoid factor (RF) titers of 24 and 271 IU/mL, respectively. All had elevated IgM antibody levels to parvovirus at the onset, and markedly elevated IgG levels when evaluated throughout their disease course. Over the course of 2 to 3 months, three improved, but the other four continued to have symptomatology for 14, 40, 78, and 120 weeks, respectively. Treatment was symptomatic, and no one developed classic SLE.CONCLUSIONS:
HPV-B19 infection in a pediatric patient group may present with SLE-like symptomatology and positive serology suggestive of SLE. The course of the disease is usually self-limited, though it may be prolonged in some for up to 120 weeks.
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Parvovirus B19 Humano
/
Infecciones por Parvoviridae
/
Lupus Eritematoso Sistémico
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
Límite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Semin Arthritis Rheum
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos