A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy.
Brain Res Mol Brain Res
; 73(1-2): 189-92, 1999 Nov 10.
Article
en En
| MEDLINE
| ID: mdl-10581413
ABSTRACT
Alanine 714 of the NMDA receptor NR1 subunit resides in the glycine binding pocket. The Ala714Leu mutation substantially shifts glycine affinity, but here no effect on antagonism by DCK is detected. Ala714Leu is also found to limit the efficacy of a partial agonist without altering its apparent affinity. The differential sensitivity of Ala714Leu to glycine agonists suggests that alanine 714 may be an intermediary in transducing the ligand binding signal.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Receptores de N-Metil-D-Aspartato
/
Agonistas de Aminoácidos Excitadores
/
Glicina
Límite:
Animals
Idioma:
En
Revista:
Brain Res Mol Brain Res
Asunto de la revista:
BIOLOGIA MOLECULAR
/
CEREBRO
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos