Simultaneous determination of cinnarizine and domepiridone maleate from tablet dosage form by reverse phase ion pair high performance liquid chromatography.
J Pharm Biomed Anal
; 19(6): 813-7, 1999 May.
Article
en En
| MEDLINE
| ID: mdl-10698546
ABSTRACT
A new simple, precise, rapid and selective reverse phase ion pair high performance liquid chromatography (HPLC-RP) method has been developed for the simultaneous determination of cinnarizine (CINN) and domepiridone maleate (DOME) from tablets using acetonitrile-methanol-water-0.1 N sulfuric acid (3710485 v/v/v/v) containing sodium lauryl sulfate (0.01 M), as a mobile phase and a Machery Nagel nitrile column (10 microns, 25 cm x 4.0 mm i.d.) as the stationary phase. The flow of mobile phase through the column was kept at 1.0 ml min(-1) through out the analysis. Detection was carried out using a UV detector at 225 nm. The retention times for CINN and DOME were 4.73 and 9.41 min, respectively. The linearity range and percentage recoveries for CINN and DOME were 4 1000 and 60-750 microg ml(-1) and 99.90 and 99.60%, respectively.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Comprimidos
/
Bloqueadores de los Canales de Calcio
/
Cromatografía Líquida de Alta Presión
/
Cinarizina
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Antagonistas de Dopamina
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Domperidona
Idioma:
En
Revista:
J Pharm Biomed Anal
Año:
1999
Tipo del documento:
Article
País de afiliación:
India