Administration of melatonin in drinking water promotes the phase advance of light-dark cycle in senescence-accelerated mice, SAMR1 but not SAMP8.
Brain Res
; 876(1-2): 220-4, 2000 Sep 08.
Article
en En
| MEDLINE
| ID: mdl-10973614
ABSTRACT
We analyzed effects of aging on behavioral rhythms in the mouse showing senescence acceleration, SAMP8 strains. The free-running rhythms had longer free-running periods (tau) in SAMP8 than in the control strain (SAMR1). Drinking of melatonin promoted the adaptation to advanced LD in SAMR1 but not in SAMP8, although both strains exhibited melatonin MT1 and MT2 receptors. The present results suggest that melatonin promotes the adaptation to advanced LD cycles in normal aging mice.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Adaptación Fisiológica
/
Fotoperiodo
/
Envejecimiento Prematuro
/
Melatonina
Límite:
Animals
Idioma:
En
Revista:
Brain Res
Año:
2000
Tipo del documento:
Article
País de afiliación:
Japón