Decreased platelet glutamate uptake in patients with amyotrophic lateral sclerosis.
Neurology
; 56(2): 270-2, 2001 Jan 23.
Article
en En
| MEDLINE
| ID: mdl-11160972
ABSTRACT
Decreased glutamate uptake and a loss of the astrocytic glutamate transporter EAAT2 (GLT-1) have been shown in spinal cord and motor cortex of patients with ALS. Because platelets express the three major glutamate transporter subtypes, including GLT-1, and possess a high-affinity glutamate uptake, the authors investigated glutamate uptake in platelets from patients with ALS and controls. A 43% reduction of high-affinity glutamate uptake rate (p < 0.0001) was observed in patients with ALS compared with normal controls and chronic neurologic disorder patients, suggesting a systemic impairment of glutamate uptake in ALS.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Plaquetas
/
Ácido Glutámico
/
Esclerosis Amiotrófica Lateral
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Neurology
Año:
2001
Tipo del documento:
Article
País de afiliación:
Italia