Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in alpha CGRP-deficient mice.
Nat Neurosci
; 4(4): 357-8, 2001 Apr.
Article
en En
| MEDLINE
| ID: mdl-11276224
ABSTRACT
The neuropeptide alpha CGRP (calcitonin gene-related peptide) is involved in the complex process of pain signaling, but the precise contribution of alpha CGRP remains unclear. Here we show that mice lacking alpha CGRP display an attenuated response to chemical pain and inflammation. Furthermore, alpha CGRP(-/-) mice do not show changes in heroin self-administration or morphine tolerance, but display a marked decrease in morphine withdrawal signs, suggesting an important contribution of alpha CGRP to opiate withdrawal.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Dolor
/
Síndrome de Abstinencia a Sustancias
/
Péptido Relacionado con Gen de Calcitonina
/
Inflamación
/
Trastornos Relacionados con Opioides
Límite:
Animals
Idioma:
En
Revista:
Nat Neurosci
Asunto de la revista:
NEUROLOGIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Francia