[Tetracyclines and ciprofloxacin as treatment for children and pregnant or lactating women in the era of biological terror].

ABSTRACT

Many forms of bacteria, such as anthrax, can be used as biological weapons. According to the CDC guidelines, Ciprofloxacin or Doxycycline is recommended for antimicrobial prophylaxis against anthrax for 60 days. Since October 8, approximately 32,000 persons with potential exposure to anthrax have initiated antimicrobial prophylaxis, mainly with Ciprofloxacin. Children and pregnant and lactating women are likely to be among the increasing number of persons receiving Ciprofloxacin or Doxycycline as a prophylaxis regardless of the potential danger of these drugs. Once the bacteria in question are shown to be sensitive to other antibiotics, treatment should be switched to antibiotics that are commonly used in children and pregnant women. The main consideration in prescribing these antibiotics is the fear of anthrax morbidity and mortality, as opposed to the risk of antibiotic side effects. The best treatment should be provided even though it can cause side effects. This paper reviews the information about the indications, dosage and side effects of Ciprofloxacin and Doxycycline in children and pregnant women and lactating women.