Effect of coumarins on mitochondrial function I. Uncoupling of oxidative phosphorlation.
Toxicology
; 4(3): 297-303, 1975 Jul.
Article
en En
| MEDLINE
| ID: mdl-125472
ABSTRACT
8-Acetyl-5,7-diemthoxy-4-phenylcoumarin at concentrations 0.03 to 0.3 mM uncoupled oxidative phosphorylation, in vitro, in rat liver mitochondria. Preincubation of mitochondria with the compound enhanced this effct. Similar uncoupling was observed with 5,7-dihydroxy-4phenylcoumarin; 7-acetonyloxycoumarin; 6,7-dimethyl-4-phenylcoumarin and 4-phenyldaphentin also. All these compounds stimulated mitochondrial ATPase activity three- to eight-fold. However, coumarin, the paretn substance of all these compounds had no effect on oxidative phosphorylation in mitochondria.
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fosforilación Oxidativa
/
Desacopladores
/
Mitocondrias Hepáticas
/
Cumarinas
Límite:
Animals
Idioma:
En
Revista:
Toxicology
Año:
1975
Tipo del documento:
Article