Effects of total body irradiation and cyclosporin a on the lethality of toxic shock syndrome toxin-1 in a rabbit model of toxic shock syndrome.
J Infect Dis
; 188(8): 1142-5, 2003 Oct 15.
Article
en En
| MEDLINE
| ID: mdl-14551884
ABSTRACT
Toxic shock syndrome (TSS) may be mediated by superantigen-activated T cells, a theory we tested in rabbits, which are more susceptible to the lethal effects of superantigens, such as TSS toxin-1 (TSST-1), than are mice. Rabbits exposed to 10 cGy of total body irradiation exhibited T cell deficiency, with profound depletion of splenic lymphocytes and circulating CD4(+) lymphocytes, as well as an inability to manifest delayed-type hypersensitivity. Nevertheless, these rabbits remained completely susceptible to TSST-1, indicating that TSS can occur in the setting of marked immunosuppression.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Choque Séptico
/
Toxinas Bacterianas
/
Irradiación Corporal Total
/
Ciclosporina
/
Enterotoxinas
/
Inmunosupresores
Límite:
Animals
Idioma:
En
Revista:
J Infect Dis
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos