The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia.
Neurosci Lett
; 353(1): 53-6, 2003 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-14642436
ABSTRACT
Neurodevelopmental abnormalities have been reported in studies on the pathogenesis of schizophrenia. The Wnt-signaling pathway has been implicated in a variety of processes in neurodevelopment, and the frizzled proteins have been identified as receptors for Wnt ligands. Of the frizzled proteins, frizzled-3 (FZD3) is required for formation of the neural crest and for development of major fiber tracts in the CNS. The human FZD3 gene is located on chromosome 8p21, a positive linkage locus for schizophrenia. We analyzed polymorphisms of the FZD3 gene in patients with schizophrenia and control subjects in the Japanese population. We found a significant association between schizophrenia and the FZD3 gene in single nucleotide polymorphisms and haplotype analyses. Our data suggest that dysregulation of the Wnt-signaling pathway may be involved in the susceptibility to schizophrenia.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Esquizofrenia
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Cromosomas Humanos Par 8
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Predisposición Genética a la Enfermedad
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Receptores Acoplados a Proteínas G
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
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Female
/
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Neurosci Lett
Año:
2003
Tipo del documento:
Article
País de afiliación:
Japón