CD36 overexpression in human brain correlates with beta-amyloid deposition but not with Alzheimer's disease.
Free Radic Biol Med
; 36(8): 1018-24, 2004 Apr 15.
Article
en En
| MEDLINE
| ID: mdl-15059642
ABSTRACT
Scavenger receptors recently have been related to Alzheimer's disease, although it is still unclear whether they contribute to the pathogenesis of the disease or reflect an inflammatory response to the deposition of amyloid beta-protein (Abeta). In this study we demonstrate that CD36, a class B scavenger receptor, is highly expressed in the cerebral cortex of Alzheimer's disease patients and cognitively normal aged subjects with diffuse amyloid plaques compared with age-matched amyloid-free control brains. Moreover, in vitro experiments indicated that Abeta is able to induce CD36 expression in neuronal cells after 24 h treatment. The interaction between CD36 and Abeta has been reported to trigger oxidant production by macrophages and microglia. In line with this observation, we found an increased presence of nitrated proteins in brains showing Abeta loads and CD36 overexpression, independent of the occurrence of Alzheimer's disease pathologic features.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Encéfalo
/
Péptidos beta-Amiloides
/
Antígenos CD36
/
Enfermedad de Alzheimer
Límite:
Aged
/
Aged80
/
Humans
Idioma:
En
Revista:
Free Radic Biol Med
Asunto de la revista:
BIOQUIMICA
/
MEDICINA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Italia