[Clinical toxicity at the infusion of cryopreserved and thawed peripheral blood stem cell grafts in children].
Rinsho Ketsueki
; 33(3): 317-21, 1992 Mar.
Article
en Ja
| MEDLINE
| ID: mdl-1578635
To test the safety of infusing cryopreserved and thawed peripheral blood stem cells (PBSC) in children, toxicity assessment was made at 36 infusions in 33 children with various types of cancer. The mean volume of PBSC graft infused was 224 ml (range, 46-500 ml) or 8.0 ml/kg (1.7-23.8 ml/kg), in containing 10% dimethylsulfoxide (DMSO). Vomiting was the only toxic feature related to the amount of DMSO. However, eight patients developed transient shock, but recovered shortly afterward with or without supportive therapy. Attention should be drawn to increased risk in children receiving thawed blood cell grafts.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Conservación de la Sangre
/
Transfusión de Sangre Autóloga
/
Leucemia Mieloide Aguda
/
Criopreservación
/
Trasplante de Células Madre
Límite:
Child
/
Female
/
Humans
/
Male
Idioma:
Ja
Revista:
Rinsho Ketsueki
Año:
1992
Tipo del documento:
Article