Ethambutol ocular toxicity in treatment regimens for Mycobacterium avium complex lung disease.
Am J Respir Crit Care Med
; 172(2): 250-3, 2005 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-15860751
ABSTRACT
Ethambutol (EMB) is an important component of multidrug treatment regimens for Mycobacterium avium complex lung disease. Ocular toxicity is the most important potential EMB toxicity, especially in the elderly population with M. avium complex lung disease. Two hundred twenty-nine patients with M. avium complex lung disease, 55% women and 53% with nodular/bronchiectatic disease, received a mean of 16.1 +/- 10.8 months of multidrug therapy that included EMB. Fifty patients (22%) were known to have preexisting ocular disease. While on EMB, 97 (42%) patients consulted an opthalmologist and 24 (10%) stopped EMB at least temporarily. Eight of 139 patients (6%) on daily therapy were diagnosed with EMB ocular toxicity, whereas 0 of 90 patients on intermittent therapy had EMB ocular toxicity (p = 0.05). All patients with EMB ocular toxicity developed symptoms between outpatient clinic appointments; none were diagnosed with routine visual acuity and color vision testing. All patients with EMB ocular disease returned to baseline ocular status after discontinuation of EMB. Intermittent EBM administration was associated with less ocular toxicity than daily EMB administration in this patient population.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Complejo Mycobacterium avium
/
Infección por Mycobacterium avium-intracellulare
/
Etambutol
/
Oftalmopatías
/
Enfermedades Pulmonares
/
Antituberculosos
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Am J Respir Crit Care Med
Asunto de la revista:
TERAPIA INTENSIVA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos