Development of a rapid autopsy program for studies of brain immunity.
J Neuroimmunol
; 163(1-2): 135-44, 2005 Jun.
Article
en En
| MEDLINE
| ID: mdl-15885316
ABSTRACT
Human glia are essential cellular models used for studies of neurodegenerative diseases. Fetal neuroglia are commonly used, as they can be recovered in large quantities and sustained for long periods in culture. However, fetal neuroglia may have limitations in reflecting adult diseases and additionally can pose ethical issues in translating products of abortion for research use. To address these concerns, we developed a rapid autopsy program to procure age- and disease-specific neuroglia from adult brain tissues within hours of death. The challenges in developing this initiative, reflecting experiences from 69 autopsies over 4 years, are presented.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Autopsia
/
Encéfalo
/
Desarrollo de Programa
/
Inmunidad Celular
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Humans
Idioma:
En
Revista:
J Neuroimmunol
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos