Deletions on mouse Yq lead to upregulation of multiple X- and Y-linked transcripts in spermatids.
Hum Mol Genet
; 14(18): 2705-15, 2005 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-16087683
ABSTRACT
Deletions on the mouse Y-chromosome long arm (MSYq) lead to teratozoospermia and in severe cases to infertility. We find that the downstream transcriptional changes in the testis resulting from the loss of MSYq-encoded transcripts involve upregulation of multiple X- and Y-linked spermatid-expressed genes, but not related autosomal genes. Therefore, this indicates that in normal males, there is a specific repression of X and Y (gonosomal) transcription in post-meiotic cells, which depends on MSYq-encoded transcripts. Together with the known sex ratio skew in favour of females in the offspring of fertile MSYqdel males, this strongly suggests the existence of an intragenomic conflict between X- and Y-linked genes. Two potential antagonists in this conflict are the X-linked multicopy gene Xmr and its multicopy MSYq-linked relative Sly, which are upregulated and downregulated, respectively, in the testes of MSYqdel males. Xmr is also expressed during meiotic sex chromosome inactivation (MSCI), indicating a link between the MSCI and the MSYq-dependent gonosomal repression in spermatids. We therefore propose that this repression and MSCI itself are evolutionary adaptations to maintain a normal sex ratio in the face of X/Y antagonism.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Espermátides
/
Cromosoma Y
/
Regulación de la Expresión Génica
/
Eliminación de Gen
/
Genes Ligados a X
/
Genes Ligados a Y
Límite:
Animals
Idioma:
En
Revista:
Hum Mol Genet
Asunto de la revista:
BIOLOGIA MOLECULAR
/
GENETICA MEDICA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Reino Unido