Allelic exclusion at DNA rearrangement level is required to prevent coexpression of two distinct T cell receptor beta genes.
J Exp Med
; 174(4): 815-9, 1991 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-1655946
ABSTRACT
In mice double transgenic for functionally rearranged T cell receptor (TCR) V beta 2 and V beta 8.2 genes we found that most T lymphocytes express both TCR beta chains simultaneously. These T cells show no abnormality in thymic selection in vivo and their TCRs are capable of transducing activation signals in vitro. These results indicate that multispecific T cells may appear in the periphery if allelic exclusion of TCR beta genes is not established at the level of gene rearrangement.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Receptores de Antígenos de Linfocitos T alfa-beta
/
Reordenamiento Génico de la Cadena beta de los Receptores de Antígenos de los Linfocitos T
Límite:
Animals
Idioma:
En
Revista:
J Exp Med
Año:
1991
Tipo del documento:
Article
País de afiliación:
Suiza