Unstable-type chromosome aberrations in lymphocytes from individuals living near Semipalatinsk nuclear test site.
J Radiat Res
; 47 Suppl A: A159-64, 2006 Feb.
Article
en En
| MEDLINE
| ID: mdl-16571932
ABSTRACT
The Semipalatinsk nuclear test site area is considered to have been highly contaminated with radioactive fallout during 40 years of continuous nuclear testing. Individuals living near the nuclear test site are considered to have been exposed to both internal and external radiation. In order to assess the effects of prolonged radiation, a chromosome analysis was performed in lymphocytes from 123 people living in three villages, Dolon, Sarjar and Kaynar, and 46 control people in Kokpekty. A micronucleus assay was also conducted in 233 people in six different contaminated villages and one control village. Frequencies of dicentric and ring chromosomes were higher in residents of the contaminated area (1.55-2.56 per 1,000 cells) than those of the non-contaminated area (0.78 per 1,000 cells). Frequencies of dicentric chromosomes with fragments were also higher in the exposed group (0.44-0.96 per 1,000 cells). Among residents of the four villages, the incidence of multiple complex chromosome aberrations (MCA) was 0.03-0.34%. Incidences of micronucleus were also higher in the exposed group (9.36-12.3 per 1,000 lymphocytes) than the non-exposed group (7.25 per 1,000 lymphocytes). The higher incidence of unstable-type aberrations such as dicentric, ring chromosomes and micronuclei found in residents of contaminated areas seems to be mainly caused by internal exposure and other factors.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Traumatismos por Radiación
/
Linfocitos
/
Pruebas de Micronúcleos
/
Aberraciones Cromosómicas
/
Medición de Riesgo
/
Guerra Nuclear
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Humans
País/Región como asunto:
Asia
/
Europa
Idioma:
En
Revista:
J Radiat Res
Año:
2006
Tipo del documento:
Article
País de afiliación:
Japón