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Osteoporosis and bone metabolism in postmenopausal women with osteoarthritis of the hand.
Zoli, Angelo; Lizzio, Marco M; Capuano, Anna; Massafra, Umberto; Barini, Angela; Ferraccioli, Gianfranco.
Afiliación
  • Zoli A; Rheumatology Division, Catholic University of Sacred Heart, Rome, Italy. angelo.zoli@rm.unicatt.it
Menopause ; 13(3): 462-6, 2006.
Article en En | MEDLINE | ID: mdl-16735943
OBJECTIVE: Osteoarthritis and osteoporosis are two major health problems affecting postmenopausal women. Epidemiological observations seem to demonstrate a possible inverse relationship between osteoarthritis and osteoporosis. Erosive osteoarthritis (EOA) of the hand is a destructive form of primary osteoarthritis. This study evaluated bone mineral density and bone metabolism changes in erosive and nonerosive hand osteoarthritis women. DESIGN: Fifty-five women (mean age, 59 years; body mass index, 23 +/- 1.4 kg/m) who had been postmenopausal for an average of 9 years and who presented with hand osteoarthritis according to American College of Rheumatology criteria were enrolled in the study; 15 women showed clinical and radiological evidence of hand EOA. Twenty women matched for age, age at menopause, and body mass index formed the control group. Bone mineral density (g/cm) was measured at the hip and lumbar spine using dual-energy x-ray absorptiometry. Serum and urinary calcium and phosphate, serum 25-hydroxyvitamin D, parathyroid hormone, osteocalcin, and urinary breakdown products of bone matrix (CrossLaps) were analyzed. RESULTS: Women with hand EOA had a statistically significant lower T- and Z-score L2-L4 value than non-hand EOA women and controls (P < 0.01). Moreover, postmenopausal women with hand EOA had higher significant percentage of osteoporosis at lumbar spine when compared with non-hand EOA postmenopausal women and controls. Any statistically significant difference in osteocalcin and CrossLaps serum levels was noted among women with hand EOA, hand osteoarthritis, and controls. CONCLUSIONS: Our data suggest that postmenopausal women with clinical and radiological EOA are at risk for development of osteoporosis.
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Osteoartritis / Osteoporosis Posmenopáusica Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans / Middle aged Idioma: En Revista: Menopause Asunto de la revista: GINECOLOGIA Año: 2006 Tipo del documento: Article País de afiliación: Italia
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Osteoartritis / Osteoporosis Posmenopáusica Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans / Middle aged Idioma: En Revista: Menopause Asunto de la revista: GINECOLOGIA Año: 2006 Tipo del documento: Article País de afiliación: Italia