Poly(ADP-ribose): novel functions for an old molecule.
Nat Rev Mol Cell Biol
; 7(7): 517-28, 2006 Jul.
Article
en En
| MEDLINE
| ID: mdl-16829982
ABSTRACT
The addition to proteins of the negatively charged polymer of ADP-ribose (PAR), which is synthesized by PAR polymerases (PARPs) from NAD(+), is a unique post-translational modification. It regulates not only cell survival and cell-death programmes, but also an increasing number of other biological functions with which novel members of the PARP family have been associated. These functions include transcriptional regulation, telomere cohesion and mitotic spindle formation during cell division, intracellular trafficking and energy metabolism.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Poli Adenosina Difosfato Ribosa
/
Poli(ADP-Ribosa) Polimerasas
/
Isoformas de Proteínas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Mol Cell Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2006
Tipo del documento:
Article
País de afiliación:
Francia