The neuroprotective adenosine-activated signal transduction pathway involves activation of phospholipase C.
Nucleosides Nucleotides Nucleic Acids
; 25(9-11): 1283-6, 2006.
Article
en En
| MEDLINE
| ID: mdl-17065107
ABSTRACT
We have demonstrated before that exposure of neuronal cultures to poisoning by iodoacetic acid (IAA) followed by "reperfusion" (IAA-R insult), results in severe cytotoxicity, which could be markedly attenuated by prior activation of the adenosine A1 receptors. We also have demonstrated that adenosine activates a signal transduction pathway (STP), which involves activation of PKC epsilon and opening of KATP channels. Here, we provide proof for the involvement also of phospholipase C (PLC) in the neuronal protective adenosine-activated STP. R-PIA, a specific A1 adenosine receptor agonist, was found to enhance neuronal PLC activity and protect against the IAA-R insult. The PLC inhibitor U73122, abrogated both R-PIA-induced effects. These results demonstrate that activation of PLC is a vital step in the neuronal protective adenosine-induced STP.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fosfolipasas de Tipo C
/
Transducción de Señal
/
Adenosina
Límite:
Animals
Idioma:
En
Revista:
Nucleosides Nucleotides Nucleic Acids
Asunto de la revista:
BIOQUIMICA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Israel