Effectiveness of a multi-disciplinary standardized management model in the treatment of chronic hepatitis C in drug addicts engaged in detoxification programmes.
Addiction
; 102(3): 423-31, 2007 Mar.
Article
en En
| MEDLINE
| ID: mdl-17298650
ABSTRACT
AIM:
To evaluate the effect of a multi-disciplinary standardized management model on the efficacy of pegylated (Peg)-interferon alpha-2b plus ribavirin treatment of chronic hepatitis C in drug addicts undergoing substitutive or antagonist therapy.DESIGN:
Observational prospective multi-centre study.SETTING:
Six clinical infectious disease centres in collaboration with 11 drug dependency units (DDU) in five Italian regions.PARTICIPANTS:
Intravenous drug users affected by chronic hepatitis C engaged in detoxification programmes.METHODS:
Application of a multi-disciplinary standardized management model for HCV treatment involving DDU operators, psychologists or psychiatrists and infectious disease specialists. MEASUREMENTS Very early, early, end-of-treatment and sustained virological response to Peg-interferon alpha-2b plus ribavirin.FINDINGS:
Fifty-three subjects were studied [43.4% with hepatitis C virus (HCV) genotypes 1 or 4]. Intent-to-treat analysis showed an end-of-treatment virological response in 58.5% of patients (39.1% genotypes 1 or 4; 73.4% genotype 3) and a sustained virological response in 54.7% (34.8% genotypes 1 or 4; 70.0% genotype 3). There were 19 (35.8%) dropouts and three (5.7%) non-responders one genotype 1 and two genotype 4. Two (3.8%) patients relapsed genotypes 1 and 3. On-treatment analysis showed negative HCV-RNA in 40 (93.1%) of 43 subjects who completed the first 12 treatment weeks and in 35 who completed the first 24 treatment weeks. All subjects with an end-of-treatment response, except one with genotype 3 infection, had a sustained response.CONCLUSIONS:
Our data show that antiviral treatment in the context of a multi-disciplinary standardized management model helps many HCV-positive drug addicts achieve a good virological response.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Antivirales
/
Ribavirina
/
Abuso de Sustancias por Vía Intravenosa
/
Interferón-alfa
/
Hepatitis C Crónica
Tipo de estudio:
Clinical_trials
/
Evaluation_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Addiction
Asunto de la revista:
TRANSTORNOS RELACIONADOS COM SUBSTANCIAS
Año:
2007
Tipo del documento:
Article
País de afiliación:
Italia