Cardioskeletal mitochondrial myopathy associated with chronic magnesium deficiency.
Neurology
; 42(1): 128-30, 1992 Jan.
Article
en En
| MEDLINE
| ID: mdl-1734293
ABSTRACT
A 3-year-old boy presenting with convulsions and carpopedal spasm had hypomagnesemia and hypermagnesuria due to congenital magnesium-losing nephropathy. Despite chronic oral and intermittent intravenous magnesium supplementation, he remained chronically hypomagnesemic. At age 4, he developed a progressive proximal myopathy and dilated hypertrophic cardiomyopathy that ultimately contributed to his death at age 14 years. Skeletal and cardiac muscle specimens showed a mitochondrial myopathy with increased numbers of enlarged, structurally abnormal mitochondria. Muscle magnesium content was markedly decreased. Chronic oral and intermittent intravenous magnesium supplementation may be inadequate to prevent the progressive cardioskeletal myopathy associated with the chronic magnesium deficiency of congenital magnesium-losing nephropathy.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Deficiencia de Magnesio
/
Mitocondrias Cardíacas
/
Mitocondrias Musculares
/
Enfermedades Musculares
/
Cardiomiopatías
Tipo de estudio:
Risk_factors_studies
Límite:
Child, preschool
/
Humans
/
Male
Idioma:
En
Revista:
Neurology
Año:
1992
Tipo del documento:
Article