Virological fitness of HIV in patients with resistance to enfuvirtide.
AIDS
; 21(14): 1974-7, 2007 Sep 12.
Article
en En
| MEDLINE
| ID: mdl-17721108
ABSTRACT
Resistance to the HIV fusion inhibitor enfuvirtide is associated with mutations in the first heptad repeat region of gp41, but little is known of their impact on replicative fitness in vivo. We followed seven patients undergoing salvage therapy that included enfuvirtide in order to document the temporal generation of genotypic and phenotypic resistance in parallel with replicative fitness. Resistance to enfuvirtide was not associated with decreased replicative fitness of HIV strains infecting these patients.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Proteína gp41 de Envoltorio del VIH
/
Infecciones por VIH
/
VIH
/
Inhibidores de Fusión de VIH
Límite:
Humans
Idioma:
En
Revista:
AIDS
Asunto de la revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Año:
2007
Tipo del documento:
Article
País de afiliación:
Australia