A role for AID in chromosome translocations between c-myc and the IgH variable region.
J Exp Med
; 204(9): 2225-32, 2007 Sep 03.
Article
en En
| MEDLINE
| ID: mdl-17724134
ABSTRACT
Chromosome translocations between oncogenes and the region spanning the immunoglobulin (Ig) heavy chain (IgH) variable (V), diversity (D), and joining (J) gene segments (Ig V-J(H) region) are found in several mature B cell lymphomas in humans and mice. The breakpoints are frequently adjacent to the recombination signal sequences targeted by recombination activating genes 1 and 2 during antigen receptor assembly in pre-B cells, suggesting that these translocations might be the result of aberrant V(D)J recombination. However, in mature B cells undergoing activation-induced cytidine deaminase (AID)-dependent somatic hypermutation (SHM), duplications or deletions that would necessitate a double-strand break make up 6% of all the Ig V-J(H) region-associated somatic mutations. Furthermore, DNA breaks can be detected at this locus in B cells undergoing SHM. To determine whether SHM might induce c-myc to Ig V-J(H) translocations, we searched for such events in both interleukin (IL) 6 transgenic (IL-6 tg) and AID(-/-) IL-6 tg mice. Here, we report that AID is required for c-myc to Ig V-J(H) translocations induced by IL-6.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Translocación Genética
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Región Variable de Inmunoglobulina
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Proteínas Proto-Oncogénicas c-myc
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Cadenas Pesadas de Inmunoglobulina
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Citidina Desaminasa
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Cromosomas de los Mamíferos
Límite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
J Exp Med
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos