Local application of capsaicin alleviates mechanical hyperalgesia after spinal nerve transection.
Neurosci Lett
; 433(3): 199-204, 2008 Mar 15.
Article
en En
| MEDLINE
| ID: mdl-18242851
ABSTRACT
Whether modulation of C afferent fiber activities could relieve peripheral neuropathic pain was tested. After establishment of neuropathic pain induced by L5 and 6 spinal nerve transection (SNT), the sciatic nerve was treated with 2% capsaicin at the level of the midthigh. Mechanical hyperalgesia (von Frey filaments) was significantly alleviated from 7 days to 4 weeks after capsaicin treatment, but cold allodynia (acetone) was unchanged. Immunohistochemical studies showed a significant increase in the number of calcitonin gene-related peptide (CGRP)-positive neurons, but not TRPV1-positive neurons in intact L4 dorsal root ganglia after SNT. Capsaicin treatment decreased TRPV1- and CGRP-positive neurons in L4 DRG of the treated side, but not the opposite side. These results suggest that local application of capsaicin onto the sciatic nerve can alleviate mechanical hyperalgesia, but not cold allodynia, in a peripheral neuropathic pain model and the pain alleviation may result from a decrease of TRPV1- and CGRP-positive sensory neurons of which fibers pass through the sciatic nerve.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Nervios Periféricos
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Capsaicina
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Enfermedades del Sistema Nervioso Periférico
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Traumatismos de los Nervios Periféricos
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Hiperalgesia
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Neuralgia
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
2008
Tipo del documento:
Article
País de afiliación:
Corea del Sur