Factors associated with hepatitis C viremia in a large cohort of HIV-infected and -uninfected women.
J Clin Virol
; 41(4): 255-63, 2008 Apr.
Article
en En
| MEDLINE
| ID: mdl-18243785
ABSTRACT
BACKGROUND:
Co-infection with hepatitis C virus (HCV) is common among HIV-infected women.OBJECTIVE:
To further our understanding of the risk factors for HCV viremia and the predictors of HCV viral load among women. STUDYDESIGN:
We investigated sociodemographic, immunologic, and virologic factors associated with presence and level of HCV viremia among 1049 HCV-seropositive women, 882 of whom were HIV-infected and 167 HIV-uninfected at their entry into the Women's Interagency HIV Study.RESULTS:
Plasma HCV RNA was detected in 852 (81%) of these 1049 women (range 1.2-7.8 log(10)copies/ml). HCV-viremic women were more likely to have an HIV RNA level >100,000 copies/ml (P=0.0004), to have reported smoking (P=0.01), or to be Black (P=0.005). They were less likely to have current or resolved hepatitis B infection. HCV RNA levels were higher in women who were >35 years old, or HIV-infected. Current smoking and history of drug use (crack/freebase cocaine, marijuana, amphetamines, or heroin) were each associated with both presence and level of viremia.CONCLUSIONS:
Substance abuse counseling aimed at eliminating ongoing use of illicit drugs and tobacco may reduce clinical progression, improve response to treatment, and decrease HCV transmission by lowering levels of HCV viremia in women.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Viremia
/
Infecciones por VIH
/
Hepatitis C
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Clin Virol
Asunto de la revista:
VIROLOGIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos