Early signals after stretch leading to cardiac hypertrophy. Key role of NHE-1.
Front Biosci
; 13: 7096-114, 2008 May 01.
Article
en En
| MEDLINE
| ID: mdl-18508719
ABSTRACT
The enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stretch is considered a key step of the intracellular signaling pathway leading to the slow force response to stretch as well as an early signal for the development of cardiac hypertrophy. We propose that the chain of events triggered by stretch begins with the release of small amounts of Angiotensin II (Ang II)/endothelin (ET) and ends with the increase in intracellular Ca2+ concentration ([Ca2+]i) through the Na+/Ca2+ exchanger in reverse mode (NCX(rev)), which triggers cardiac hypertrophy by activation of widely recognized Ca2+-dependent intracellular signaling pathways.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cardiomegalia
/
Intercambiadores de Sodio-Hidrógeno
Límite:
Adult
/
Humans
Idioma:
En
Revista:
Front Biosci
Asunto de la revista:
BIOLOGIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Argentina